ID  Q5SV85;
PN  Synergin gamma;
GN  Synrg;
OS  10090;
SL  Nucleus Position: SL-0198;
SL  Comments: Cytoplasm, cytosol {ECO:0000269|PubMed:12808037}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:12808037}; Peripheral membrane protein {ECO:0000269|PubMed:12808037}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q9UMZ2}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000250|UniProtKB:Q9UMZ2}. Note=Localization at clathrin- coated vesicles depends on AFTPH/aftiphilin (By similarity). Associates with membranes via the adapter protein complex AP-1 (By similarity). Colocalizes with AP1G1 (By similarity). {ECO:0000250|UniProtKB:Q9JKC9, ECO:0000250|UniProtKB:Q9UMZ2}.
DR  UNIPROT: Q5SV85;
DR  UNIPROT: Q5SV84;
DR  UNIPROT: Q6PHT6;
DR  PROSITE: PS50031;
DE  Function: Plays a role in endocytosis and/or membrane trafficking at the trans-Golgi network (TGN) (By similarity). May act by linking the adapter protein complex AP-1 to other proteins (By similarity). Component of clathrin-coated vesicles (By similarity). Component of the aftiphilin/p200/gamma-synergin complex, which plays roles in AP1G1/AP- 1-mediated protein trafficking including the trafficking of transferrin from early to recycling endosomes, and the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes (By similarity). {ECO:0000250|UniProtKB:Q9UMZ2}.
DE  Reference Proteome: Yes;
GO  GO:0030130;
GO  GO:0005829;
GO  GO:0048471;
GO  GO:0006897;
GO  GO:0015031;
TP  Membrane Topology: Peripheral; Source: UniProt - Experimental Evidence {ECO:0000269|PubMed:12808037};
SQ  MALRPGAGASGAAGAGAGPGGAGSFMFPVAGGMRPPQAGLIPMQQQGFPMVSVMQPNMQGMMGMNYSSQMSQGPIAMQAG
SQ  IPMGPMPAAGVPFLGQPPFLSMRPAGPQYTPDMQKQFAEEQQKRFEQQQKLLEEERKRRQFEEQKQKLRLLSSVKPKTGE
SQ  KNRDDALEAIKGNLDGFSRDAKMHPTPASHPKKQGPSLEEKLLVSCDVSASGQEHIKLNTPDAGHKAIVPGSSKNCPGLM
SQ  AHNRGAVDGCVSGPASAEAEKTSDQTLSKEESGVGVFPSQDPAQSRMPPWIYNESLVPDAYKKILETTMTPTGIDTAKLY
SQ  PILMSSGLPRETLGQIWALANRTTPGRLTKEELYTVLAMVAVTQRGVPAMSPDALSQFPAAPIPTLSGFPMTLPTPVSQP
SQ  TAMPSGPTGSMPLTLGQPIMGINLVGPVGGAAAPTSSGFMPAYPSNQVGKTEEDDFQDFQDASKSGSIDDSFTDFQEMPA
SQ  SSKTSNSQHGNSAPSLLIPFPGTKASTDKYAVFKGISTDKPSENPASFGESGDKYSAFRELEQTTDSKPLGESFAEFRST
SQ  GTDDGFTDFKTADSVSPLEPPTKDTFPSAFASGAAQQTQTQVKTPLNLEDLDMFSSVDCSGEKQVPFSATFSTAKSVSTR
SQ  PQPAGSAAASAALASTKTSSLADDFGEFNLFGEYSNPASAGEQDDFADFMAFGNSSISSEPKASDKYEALREEVSPSPLS
SQ  SSTVEGAQHPPAAATKYDVFKQLSLEGAGLAMEEFKENTSSTKSEDDFADFHSSKFSSTSSDKSLGEKAVAFRHAKEDSS
SQ  SVKSLDLPSIGGSSVGKEDSEDALSVQFDMKLADVGGDLKHVMSDSSLDLPTVSGQHPPAADTEDLSCAAFGSCSSHFTV
SQ  STLTSCEWSDRADALQGRKLSPFVLSAGSRSFSATSNLHTKEISFGSSENITMSSLSKGSALASEDALPETAFPAFASFK
SQ  DMMPQTTEQKEFESGDFQDFTRQDMPTVDRSQETSCPSPASSVASHETPKEGADDFGEFQSEKSKISKFDFLVANSQSKM
SQ  KSSEEMIKSELATFDLSVQGSHKRSLSLGDKEISRSSPSPALEQPFRDRSNTLSERAALPVIRDKYKDLTGEVEENERYA
SQ  YEWQRCLGSALDVIKKANDTLNGISSSAVCTEVIQSAQGMEYLLGVVEVYRVTKRVELGIKATAVCSEKLQQLLKDIDKV
SQ  WNNLIGFMSLATLTPDENSLDFSSCMLRPGIKNAQELACGVCLLNVDSRSRKEETPAEEQPKKAFNSETDSFKLAYGGHQ
SQ  YHASCANFWINCVEPKPPGLLLPDLL
//