ID  Q5SXA9;
PN  Protein KIBRA;
GN  Wwc1;
OS  10090;
SL  Nucleus Position: SL-0198;
SL  Comments: Cytoplasm {ECO:0000269|PubMed:18190796}. Cytoplasm, perinuclear region {ECO:0000250}. Nucleus {ECO:0000250}. Cell projection, ruffle membrane {ECO:0000250}. Note=Colocalizes with PRKCZ in the perinuclear region. {ECO:0000250}.
DR  UNIPROT: Q5SXA9;
DR  UNIPROT: Q571D0;
DR  UNIPROT: Q8K1Y3;
DR  UNIPROT: Q8VD17;
DR  UNIPROT: Q922W3;
DR  PDB: 6J68;
DR  PDB: 6J69;
DR  PDB: 6JJW;
DR  PDB: 6JJX;
DR  PDB: 6JJY;
DR  Pfam: PF00168;
DR  Pfam: PF00397;
DR  PROSITE: PS50004;
DR  PROSITE: PS01159;
DR  PROSITE: PS50020;
DE  Function: Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with NF2 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. Acts as a transcriptional coactivator of ESR1 which plays an essential role in DYNLL1-mediated ESR1 transactivation. Regulates collagen-stimulated activation of the ERK/MAPK cascade. Modulates directional migration of podocytes. Acts as a substrate for PRKCZ and may be associated with memory performance (By similarity). Regulates collagen-stimulated activation of the ERK/MAPK cascade. {ECO:0000250, ECO:0000269|PubMed:18190796}.
DE  Reference Proteome: Yes;
GO  GO:0005737;
GO  GO:0005829;
GO  GO:0005634;
GO  GO:0048471;
GO  GO:0032991;
GO  GO:0032587;
GO  GO:0019900;
GO  GO:0060090;
GO  GO:0030674;
GO  GO:0003713;
GO  GO:0016477;
GO  GO:0035331;
GO  GO:0046621;
GO  GO:0000122;
GO  GO:0043410;
GO  GO:0006355;
GO  GO:0035330;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MPRPELPLPEGWEEARDFDGKVYYIDHRNRTTSWIDPRDRYTKPLTFADCISDELPLGWEEAYDPQVGDYFIDHNTKTTQ
SQ  IEDPRVQWRREQEHMLKDYLVVAQEALSAQKEIYQVKQQRLELAQQEYQQLHAVWEHKLGSQVSLVSGSSSSSKYDPEIL
SQ  KAEIATAKSRVNKLKREMVHLQHELQFKERGFQTLKKIDERMSDAQGGYKLDEAQAVLRETKAIKKAITCGEKEKQDLIK
SQ  SLAMLKDGFRTDRGSHSDLWSSSSSLESSSFPMPKQFLDVSSQTDISGSFSTSSNNQLAEKVRLRLRYEEAKRRIANLKI
SQ  QLAKLDSEAWPGVLDSERDRLILINEKEELLKEMRFISPRKWTQGEVEQLEMARRRLEKDLQAARDTQSKALTERLKLNS
SQ  KRNQLVRELEEATRQVATLHSQLKSLSSSMQSLSSGSSPGSLTSSRGSLAASSLDSSTSASFTDLYYDPFEQLDSELQSK
SQ  VELLFLEGATGFRPSGCITTIHEDEVAKTQKAEGGSRLQALRSLSGTPRSMTSLSPRSSLSSPSPPCSPLITDPLLTGDA
SQ  FLAPLEFEDTELSTTLCELNLGGSGTQERYRLEEPGPEGKPLGQAASVAPGCGLKVACVSAAVSDESVAGDSGVYEASAQ
SQ  RPGTSEAAAFDSDESEAVGATRVQIALKYDEKNKQFAILIIQLSHLSALSLQQDQKVNIRVAILPCSESSTCLFRTRPLD
SQ  SANTLVFNEAFWVSISYPALHQKTLRVDVCTTDRSHTEECLGGAQISLAEVCRSGERSTRWYNLLSYKYLKKQCREPQPT
SQ  EAPGPDHVDAVSALLEQTAVELEKRQEGRSSSQTLEGSWTYEEEASENEAVAEEEEEGEEDVFTEKVSPEAEECPALKVD
SQ  RETNTDSVAPSPTVVRPKDRRVGAPSTGPFLRGNTIIRSKTFSPGPQSQYVCRLNRSDSDSSTLSKKPPFVRNSLERRSV
SQ  RMKRPSSVKSLRTERLIRTSLDLELDLQATRTWHSQLTQEISVLKELKEHLEQAKNHGEKELPQWLREDERFRLLLRMLE
SQ  KKVDRGEHKSELQADKMMRAAAKDVHRLRGQSCKEPPEVQSFREKMAFFTRPRMNIPALSADDV
//