ID  Q5T447;
PN  E3 ubiquitin-protein ligase HECTD3;
GN  HECTD3;
OS  9606;
SL  Nucleus Position: SL-0198;
SL  Comments: Cytoplasm, perinuclear region {ECO:0000250}.
DR  UNIPROT: Q5T447;
DR  UNIPROT: B3KPV7;
DR  UNIPROT: B3KRH4;
DR  UNIPROT: Q5T448;
DR  UNIPROT: Q9H783;
DR  Pfam: PF03256;
DR  Pfam: PF00632;
DR  PROSITE: PS51284;
DR  PROSITE: PS50237;
DR  OMIM: 618638;
DR  DisGeNET: 79654;
DE  Function: E3 ubiquitin ligases accepts ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of TRIOBP and its subsequent proteasomal degradation, thus facilitating cell cycle progression by regulating the turn-over of TRIOBP. Mediates also ubiquitination of STX8 (By similarity). {ECO:0000250|UniProtKB:Q3U487, ECO:0000269|PubMed:18194665}.
DE  Reference Proteome: Yes;
DE  Interaction: P0DTD1; IntAct: EBI-27126088; Score: 0.35
DE  Interaction: Q15796; IntAct: EBI-2691165; Score: 0.00
DE  Interaction: Q7Z434; IntAct: EBI-6115727; Score: 0.35
DE  Interaction: P08238; IntAct: EBI-6425955; Score: 0.40
DE  Interaction: Q8IUH5; IntAct: EBI-9088791; Score: 0.37
DE  Interaction: O60437; IntAct: EBI-24537202; Score: 0.56
DE  Interaction: D2XQB9; IntAct: EBI-14063588; Score: 0.35
DE  Interaction: Q8N5F7; IntAct: EBI-21520423; Score: 0.35
DE  Interaction: P82930; IntAct: EBI-21521832; Score: 0.35
DE  Interaction: P13994; IntAct: EBI-21552344; Score: 0.35
DE  Interaction: Q8N0V3; IntAct: EBI-21561897; Score: 0.35
DE  Interaction: Q8IUX8; IntAct: EBI-21565522; Score: 0.35
DE  Interaction: Q6UWQ5; IntAct: EBI-21641185; Score: 0.35
DE  Interaction: Q7Z4W2; IntAct: EBI-21670934; Score: 0.35
DE  Interaction: O75596; IntAct: EBI-21674079; Score: 0.35
DE  Interaction: Q6IN84; IntAct: EBI-21721548; Score: 0.35
DE  Interaction: Q96NG3; IntAct: EBI-21726764; Score: 0.35
DE  Interaction: P05154; IntAct: EBI-21730352; Score: 0.35
DE  Interaction: Q8N4T0; IntAct: EBI-21731449; Score: 0.35
DE  Interaction: A8MT70; IntAct: EBI-21738250; Score: 0.35
DE  Interaction: O15123; IntAct: EBI-21738454; Score: 0.35
DE  Interaction: P01350; IntAct: EBI-21738479; Score: 0.35
DE  Interaction: P15408; IntAct: EBI-21738528; Score: 0.35
DE  Interaction: E7EPC3; IntAct: EBI-21738429; Score: 0.35
DE  Interaction: Q2MKA7; IntAct: EBI-21738795; Score: 0.35
DE  Interaction: Q9BU40; IntAct: EBI-21739567; Score: 0.35
DE  Interaction: Q6NZI2; IntAct: EBI-21738912; Score: 0.35
DE  Interaction: Q7L0Y3; IntAct: EBI-21739027; Score: 0.35
DE  Interaction: Q8NBL1; IntAct: EBI-21739323; Score: 0.35
DE  Interaction: Q8NBX0; IntAct: EBI-21739378; Score: 0.35
DE  Interaction: Q96EL2; IntAct: EBI-21739451; Score: 0.35
DE  Interaction: Q9BYG5; IntAct: EBI-21739610; Score: 0.35
DE  Interaction: Q9H9Q2; IntAct: EBI-21739689; Score: 0.35
DE  Interaction: Q9H1F0; IntAct: EBI-21739868; Score: 0.35
DE  Interaction: Q99501; IntAct: EBI-21832664; Score: 0.35
DE  Interaction: P62701; IntAct: EBI-21876649; Score: 0.40
DE  Interaction: Q96PQ6; IntAct: EBI-21890582; Score: 0.35
DE  Interaction: P11166; IntAct: EBI-20903936; Score: 0.40
DE  Interaction: O84388; IntAct: EBI-22302856; Score: 0.35
DE  Interaction: P0DOF2; IntAct: EBI-25603126; Score: 0.35
DE  Interaction: P22607; IntAct: EBI-25854798; Score: 0.56
DE  Interaction: Q14957; IntAct: EBI-25862911; Score: 0.56
DE  Interaction: P06396; IntAct: EBI-25864492; Score: 0.56
DE  Interaction: Q9Y649; IntAct: EBI-25901376; Score: 0.56
DE  Interaction: Q9UMX0; IntAct: EBI-25921251; Score: 0.56
DE  Interaction: Q6ZNK6; IntAct: EBI-26453464; Score: 0.35
DE  Interaction: P34972; IntAct: EBI-26880846; Score: 0.35
GO  GO:0048471;
GO  GO:0019905;
GO  GO:0004842;
GO  GO:0043161;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MAGPGPGAVLESPRQLLGRVRFLAEAARSLRAGRPLPAALAFVPREVLYKLYKDPAGPSRVLLPVWEAEGLGLRVGAAGP
SQ  APGTGSGPLRAARDSIELRRGACVRTTGEELCNGHGLWVKLTKEQLAEHLGDCGLQEGWLLVCRPAEGGARLVPIDTPNH
SQ  LQRQQQLFGVDYRPVLRWEQVVDLTYSHRLGSRPQPAEAYAEAVQRLLYVPPTWTYECDEDLIHFLYDHLGKEDENLGSV
SQ  KQYVESIDVSSYTEEFNVSCLTDSNADTYWESDGSQCQHWVRLTMKKGTIVKKLLLTVDTTDDNFMPKRVVVYGGEGDNL
SQ  KKLSDVSIDETLIGDVCVLEDMTVHLPIIEIRIVECRDDGIDVRLRGVKIKSSRQRELGLNADLFQPTSLVRYPRLEGTD
SQ  PEVLYRRAVLLQRFIKILDSVLHHLVPAWDHTLGTFSEIKQVKQFLLLSRQRPGLVAQCLRDSESSKPSFMPRLYINRRL
SQ  AMEHRACPSRDPACKNAVFTQVYEGLKPSDKYEKPLDYRWPMRYDQWWECKFIAEGIIDQGGGFRDSLADMSEELCPSSA
SQ  DTPVPLPFFVRTANQGNGTGEARDMYVPNPSCRDFAKYEWIGQLMGAALRGKEFLVLALPGFVWKQLSGEEVSWSKDFPA
SQ  VDSVLVKLLEVMEGMDKETFEFKFGKELTFTTVLSDQQVVELIPGGAGIVVGYGDRSRFIQLVQKARLEESKEQVAAMQA
SQ  GLLKVVPQAVLDLLTWQELEKKVCGDPEVTVDALRKLTRFEDFEPSDSRVQYFWEALNNFTNEDRSRFLRFVTGRSRLPA
SQ  RIYIYPDKLGYETTDALPESSTCSSTLFLPHYASAKVCEEKLRYAAYNCVAIDTDMSPWEE
//