ID  Q5U651;
PN  Ras-interacting protein 1;
GN  RASIP1;
OS  9606;
SL  Nucleus Position: SL-0198;
SL  Comments: Cytoplasm, perinuclear region {ECO:0000269|PubMed:15031288}. Golgi apparatus, Golgi stack {ECO:0000269|PubMed:15031288}. Note=Associated with perinuclear vesicles. Is recruited to Golgi stacks by activated HRAS.
DR  UNIPROT: Q5U651;
DR  UNIPROT: Q6U676;
DR  PDB: 5KHO;
DR  PDB: 5KHQ;
DR  Pfam: PF01843;
DR  Pfam: PF00788;
DR  PROSITE: PS51126;
DR  PROSITE: PS50200;
DR  OMIM: 609623;
DR  DisGeNET: 54922;
DE  Function: Required for the proper formation of vascular structures that develop via both vasculogenesis and angiogenesis. Acts as a critical and vascular-specific regulator of GTPase signaling, cell architecture, and adhesion, which is essential for endothelial cell morphogenesis and blood vessel tubulogenesis. Regulates the activity of Rho GTPases in part by recruiting ARHGAP29 and suppressing RhoA signaling and dampening ROCK and MYH9 activities in endothelial cells (By similarity). May act as effector for Golgi-bound HRAS and other Ras- like proteins. May promote HRAS-mediated transformation. Negative regulator of amino acid starvation-induced autophagy. {ECO:0000250, ECO:0000269|PubMed:15031288, ECO:0000269|PubMed:22354037}.
DE  Reference Proteome: Yes;
DE  Interaction: Q5NI89; IntAct: EBI-2797128; Score: 0.00
DE  Interaction: A0A0H2W4P6; IntAct: EBI-2856635; Score: 0.00
DE  Interaction: Q8N6T3; IntAct: EBI-3924759; Score: 0.37
DE  Interaction: P60953; IntAct: EBI-11002356; Score: 0.35
DE  Interaction: Q9H0H5; IntAct: EBI-11003256; Score: 0.35
DE  Interaction: O95229; IntAct: EBI-11007376; Score: 0.35
DE  Interaction: Q9H4P4; IntAct: EBI-11011881; Score: 0.35
DE  Interaction: Q7TSY8; IntAct: EBI-11024934; Score: 0.35
DE  Interaction: Q9DC28; IntAct: EBI-11075774; Score: 0.35
DE  Interaction: Q9JLB0; IntAct: EBI-11079122; Score: 0.35
DE  Interaction: Q9NVK5; IntAct: EBI-11131799; Score: 0.35
DE  Interaction: Q9BRV8; IntAct: EBI-11132072; Score: 0.35
DE  Interaction: O95817; IntAct: EBI-11135110; Score: 0.35
DE  Interaction: Q99PU7; IntAct: EBI-11138635; Score: 0.35
DE  Interaction: Q14103; IntAct: EBI-11152836; Score: 0.35
DE  Interaction: O43684; IntAct: EBI-11163266; Score: 0.35
DE  Interaction: Q6NYC8; IntAct: EBI-21774730; Score: 0.35
DE  Interaction: O43679; IntAct: EBI-15690604; Score: 0.37
DE  Interaction: P23528; IntAct: EBI-20904352; Score: 0.40
GO  GO:0005911;
GO  GO:0005795;
GO  GO:0048471;
GO  GO:0032991;
GO  GO:0051020;
GO  GO:0042803;
GO  GO:0001525;
GO  GO:0048754;
GO  GO:0010507;
GO  GO:1905709;
GO  GO:0035024;
GO  GO:2000299;
GO  GO:0033625;
GO  GO:0043087;
GO  GO:0007165;
GO  GO:0001570;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MLSGERKEGGSPRFGKLHLPVGLWINSPRKQLAKLGRRWPSAASVKSSSSDTGSRSSEPLPPPPPHVELRRVGAVKAAGG
SQ  ASGSRAKRISQLFRGSGTGTTGSSGAGGPGTPGGAQRWASEKKLPELAAGVAPEPPLATRATAPPGVLKIFGAGLASGAN
SQ  YKSVLATARSTARELVAEALERYGLAGSPGGGPGESSCVDAFALCDALGRPAAAGVGSGEWRAEHLRVLGDSERPLLVQE
SQ  LWRARPGWARRFELRGREEARRLEQEAFGAADSEGTGAPSWRPQKNRSRAASGGAALASPGPGTGSGAPAGSGGKERSEN
SQ  LSLRRSVSELSLQGRRRRQQERRQQALSMAPGAADAQIGTADPGDFDQLTQCLIQAPSNRPYFLLLQGYQDAQDFVVYVM
SQ  TREQHVFGRGGNSSGRGGSPAPYVDTFLNAPDILPRHCTVRAGPEHPAMVRPSRGAPVTHNGCLLLREAELHPGDLLGLG
SQ  EHFLFMYKDPRTGGSGPARPPWLPARPGATPPGPGWAFSCRLCGRGLQERGEALAAYLDGREPVLRFRPREEEALLGEIV
SQ  RAAAAGSGDLPPLGPATLLALCVQHSARELELGHLPRLLGRLARLIKEAVWEKIKEIGDRQPENHPEGVPEVPLTPEAVS
SQ  VELRPLMLWMANTTELLSFVQEKVLEMEKEADQEDPQLCNDLELCDEAMALLDEVIMCTFQQSVYYLTKTLYSTLPALLD
SQ  SNPFTAGAELPGPGAELGAMPPGLRPTLGVFQAALELTSQCELHPDLVSQTFGYLFFFSNASLLNSLMERGQGRPFYQWS
SQ  RAVQIRTNLDLVLDWLQGAGLGDIATEFFRKLSMAVNLLCVPRTSLLKASWSSLRTDHPTLTPAQLHHLLSHYQLGPGRG
SQ  PPAAWDPPPAEREAVDTGDIFESFSSHPPLILPLGSSRLRLTGPVTDDALHRELRRLRRLLWDLEQQELPANYRHGPPVA
SQ  TSP
//