ID  Q5VWP3;
PN  Muscular LMNA-interacting protein;
GN  MLIP;
OS  9606;
SL  Nucleus Position: SL-0178;
SL  Comments: Nucleus {ECO:0000250|UniProtKB:Q5FW52}. Nucleus envelope {ECO:0000250|UniProtKB:Q5FW52}. Nucleus, PML body {ECO:0000250|UniProtKB:Q5FW52}. Cell membrane, sarcolemma {ECO:0000250|UniProtKB:Q5FW52}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q5FW52}; Cytoplasmic side {ECO:0000250|UniProtKB:Q5FW52}.
DR  UNIPROT: Q5VWP3;
DR  UNIPROT: B7Z2N0;
DR  UNIPROT: D6RE05;
DR  UNIPROT: Q96H08;
DR  UNIPROT: Q96NF7;
DR  Pfam: PF15274;
DR  OMIM: 614106;
DR  DisGeNET: 90523;
DE  Function: Required for precocious cardiac adaptation to stress through integrated regulation of the AKT/mTOR pathways and FOXO1. Regulates cardiac homeostasis and plays an important role in protection against cardiac hypertrophy. Acts as a transcriptional cofactor, represses transactivator activity of ISL1 and MYOCD. {ECO:0000250|UniProtKB:A0A096MK47, ECO:0000250|UniProtKB:Q5FW52}.
DE  Disease: Note=Expression is reduced in patients with dilated cardiomyocytes. In murine cardiomyopathy models, deletion of the encoding gene accelerates progress from hypertrophy to heart failure. {ECO:0000269|PubMed:26436652}.
DE  Reference Proteome: Yes;
DE  Interaction: P02545; IntAct: EBI-3895433; Score: 0.37
DE  Interaction: P45984; IntAct: EBI-25254847; Score: 0.56
GO  GO:0005635;
GO  GO:0031981;
GO  GO:0005634;
GO  GO:0016605;
GO  GO:0042383;
GO  GO:0005521;
GO  GO:0003714;
GO  GO:0010614;
GO  GO:1903243;
GO  GO:0000122;
GO  GO:0045944;
TP  Membrane Topology: Peripheral; Source: UniProt - By Similarity {ECO:0000250|UniProtKB:Q5FW52};
SQ  MELEKREKRSLLNKNLEEKLTVSAGGSEAKPLIFTFVPTVRRLPTHTQLADTSKFLVKIPEESSDKSPETVNRSKSNDYL
SQ  TLNAGSQQERDQAKLTCPSEVSGTILQEREFEANKLQGMQQSDLFKAEYVLIVDSEGEDEAASRKVEQGPPGGIGTAAVR
SQ  PKSLAISSSLVSDVVRPKTQGTDLKTSSHPEMLHGMAPQQKHGQQYKTKSSYKAFAAIPTNTLLLEQKALDEPAKTESVS
SQ  KDNTLEPPVELYFPAQLRQQTEELCATIDKVLQDSLSMHSSDSPSRSPKTLLGSDTVKTPTTLPRAAGRETKYANLSSPS
SQ  STVSESQLTKPGVIRPVPVKSRILLKKEEEVYEPNPFSKYLEDNSDLFSEQDVTVPPKPVSLHPLYQTKLYPPAKSLLHP
SQ  QTLSHADCLAPGPFSHLSFSLSDEQENSHTLLSHNACNKLSHPMVAIPEHEALDSKEQ
//