ID Q5XGI3; PN F-box/LRR-repeat protein 5; GN fbxl5; OS 8364; SL Nucleus Position: SL-0198; SL Comments: Cytoplasm, perinuclear region {ECO:0000250}. DR UNIPROT: Q5XGI3; DR Pfam: PF12937; DR Pfam: PF01814; DR Pfam: PF13516; DR PROSITE: PS50181; DE Function: Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in iron homeostasis by promoting the ubiquitination and subsequent degradation of ireb2/irp2. Upon high iron and oxygen level, it specifically recognizes and binds ireb2/irp2, promoting its ubiquitination and degradation by the proteasome (By similarity). {ECO:0000250}. DE Reference Proteome: Yes; GO GO:0048471; GO GO:0019005; GO GO:0005506; GO GO:0055072; GO GO:0016567; GO GO:0031146; TP Membrane Topology: Unknown; Source: UniProt - Sequence Analysis; SQ MAPFPDEVDLFTGPHWRMKQLVGRYCEKLSNTNFSSNTDFLALLQSLYETFKEFKMHEQIENEYIIGLLQQRSQTVFNVH SQ SDNKLSEMLVLFEKGMKNNEYEQLNYAQQLKERLEAFTSDFLPHMKEEEEVFQPMLMEYFTYDELKDIKKKVIAQHCSQK SQ DTAELLRGFSLWNKAEELQKVFKYSVDEKIERDSKNRKSSASICNLPPEVMLNIFSYLNPQDLCRCSQVNTKWAQLARTG SQ SLWRHLYPVLWARGDWYSGPPTHLDNEPDEDWISRRKDESRAYQEWDEDADIDESEETGEDDPSISVAQREKELLNSLVH SQ YILPYIGHSVKTLVLAYSSATSNKVIRQILEYCPNMEHLDLTQTDISDSAFNGWCFGACQTLRHIDLSGCEKITDSALEK SQ LSVALGMPLAHKKRLLKCYRNNRTVKDIRNQMRCGSLAQITGESGIYSDYSSSQIWILNSGNLGDIEDAADWKFRTTDGL SQ GVLEMTPNLTCFSNGCCSRAVPGRWTNVIRQEHCKAAPLNYCGHTLCGNTLRTIQALPGSNIGTKTLQSEIRDICPGSAK SQ LDQQVARVLQFLSLSGCHQITDHGLRVLTIGGGLPNLEHLNLSGCLNVTGSGLQDLVSACPSLNDEHFYYCDNISGPHAA SQ TASGCQNLQCGFRACCRSGE //