ID  Q5XHG1;
PN  Sphingomyelin phosphodiesterase 4;
GN  smpd4;
OS  8355;
SL  Nucleus Position: SL-0178;
SL  Comments: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9NXE4}; Single-pass membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q9NXE4}; Single-pass membrane protein {ECO:0000255}. Nucleus envelope {ECO:0000250|UniProtKB:Q9NXE4}. Cell membrane, sarcolemma {ECO:0000250|UniProtKB:Q6ZPR5}.
DR  UNIPROT: Q5XHG1;
DR  UNIPROT: Q4V7Y8;
DR  Pfam: PF14724;
DE  Function: Catalyzes the hydrolysis of membrane sphingomyelin to form phosphorylcholine and ceramide. It has a relevant role in the homeostasis of membrane sphingolipids, thereby influencing membrane integrity, and endoplasmic reticulum organization and function. May sensitize cells to DNA damage-induced apoptosis. {ECO:0000250|UniProtKB:Q9NXE4}.
DE  Reference Proteome: Yes;
GO  GO:0005783;
GO  GO:0005789;
GO  GO:0000139;
GO  GO:0016021;
GO  GO:0005635;
GO  GO:0042383;
GO  GO:0046872;
GO  GO:0004767;
GO  GO:0050290;
GO  GO:0071356;
GO  GO:0046513;
GO  GO:0006685;
TP  Membrane Topology: Transmembrane; Source: UniProt - Sequence Analysis {ECO:0000255};
SQ  MLLAGGSPQPSFLLGSLKADCVTKPFLQRCQDLVRVIEDFPAKELHAIFPWLIETVFGSLDGSILGWNLRGLHERINPLE
SQ  FHTALEFLDPSGAMMKLVYKLQAEEYKYDFPVSFLPGPVRASIQERVLPECPLYHNKIQFPASGGVSFNLALNSFEYFMF
SQ  HFAFCLLKQRNYPQGLHFSTADSAYYILVDKYLKWFLPVEGNVPPPHSPNTGGTVPSPAPRSPSLSFTSYGSHTSLLKRH
SQ  ISHQHLVNADPAAQEIWRTETLLQVFVEIWLHHYSLEMYQKMQSPNAKLEALHNRLSVSSAPPIYPALPGSLHSYQELFQ
SQ  PTEEHVLVVRLLVKHLHTFSNSIRPEQVSPSTHSHTASPLEELKRVVVPRFIQQKLYIFLQHCFGHWPLDASFRAVLEMW
SQ  LSYVQPWRYVLERSSPVSGEMQNRNVPEKWSTFVQENLLFYTKLFLRFLSRALRTDLVNPKNALMVFRAAKVFSQLNLPE
SQ  MILNGEQLFLKPEHVIPHRQHRLLLTPNLGGSFLSSWQPPITDTSLKVKSHVFSLEGQDCQYMQMFGPEARNLVLRLAQM
SQ  ISQAKQTAKSISNHSPDSSANQSFLSWFGLGSPDFNGSYNGSDLDEAGYDTIRKTDEHLEKALDYFCQIFRLNPTQLGQL
SQ  TANVDSSQDDDGKNKLPDCIQSEDGVVLTSLGRYQIINGLRKFDIEYQGDPELQPIRSYENAMLVRYLYRLSSVINKRFA
SQ  NSMGALCARKDFLGKLCRHHLTSSSRKCKKSPITSVSPSEPAAPHIRLRFLASYRTLAFLFIFYILGSLLSLGPLICTFL
SQ  LLIGCMFYAIVQTLLSEEQKPHNN
//