ID  Q5XIU9;
PN  Membrane-associated progesterone receptor component 2;
GN  Pgrmc2;
OS  10116;
SL  Nucleus Position: SL-0178;
SL  Comments: Membrane {ECO:0000250|UniProtKB:Q80UU9}; Single- pass membrane protein {ECO:0000250|UniProtKB:Q80UU9}. Nucleus envelope {ECO:0000250|UniProtKB:O15173}. Endoplasmic reticulum {ECO:0000250|UniProtKB:O15173}.
DR  UNIPROT: Q5XIU9;
DR  Pfam: PF00173;
DE  Function: Required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan. May serve as a universal non- classical progesterone receptor in the uterus. Intracellular heme chaperone required for delivery of labile, or signaling heme, to the nucleus. Plays a role in adipocyte function and systemic glucose homeostasis. In brown fat, which has a high demand for heme, delivery of labile heme in the nucleus regulates the activity of heme-responsive transcriptional repressors such as NR1D1 and BACH1. {ECO:0000250|UniProtKB:Q80UU9}.
DE  Reference Proteome: Yes;
DE  Interaction: P19357; IntAct: EBI-921030; Score: 0.35
GO  GO:0012505;
GO  GO:0005783;
GO  GO:0016021;
GO  GO:0016020;
GO  GO:0005635;
GO  GO:0020037;
GO  GO:0015232;
GO  GO:0005496;
GO  GO:0060612;
GO  GO:0015886;
TP  Membrane Topology: Transmembrane; Source: UniProt - Sequence Analysis {ECO:0000255};
SQ  MAAGDGDVKLSTLGSGGERGGDGSPGGAGATAARSSWVAALLATGGEMLLNVALVALVLLGAYRLWVRWGRRGLCSGPGA
SQ  GEESPAATLPRMKKRDFSLEQLRQYDGARTPRILLAVNGKVFDVTKGSKFYGPAGPYGIFAGRDASRGLATFCLDKDALR
SQ  DEYDDLSDLNAVQMESVREWEMQFKEKYDYVGRLLKPGEEPSEYTDEEDTKDHSKQD
//