ID  Q5ZKD9;
PN  Kelch-like protein 20;
GN  KLHL20;
OS  9031;
SL  Nucleus Position: SL-0198;
SL  Comments: Cytoplasm, perinuclear region {ECO:0000250}. Nucleus {ECO:0000250}.
DR  UNIPROT: Q5ZKD9;
DR  Pfam: PF07707;
DR  Pfam: PF00651;
DR  Pfam: PF01344;
DR  PROSITE: PS50097;
DE  Function: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. The BCR(KLHL20) E3 ubiquitin ligase complex mediates the ubiquitination of target proteins, leading to their degradation by the proteasome. It also specifically mediates 'Lys-33'-linked ubiquitination (By similarity). {ECO:0000250}.
DE  Reference Proteome: Yes;
GO  GO:0031463;
GO  GO:0005737;
GO  GO:0005829;
GO  GO:0048471;
GO  GO:0016605;
GO  GO:0005802;
GO  GO:0019964;
GO  GO:0004842;
GO  GO:0006895;
GO  GO:0043066;
GO  GO:0043161;
GO  GO:1990390;
GO  GO:0015031;
GO  GO:0016567;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MDGKPMRRCTSTRPGETGMDVTSRCTLGDPNKLPEGVPQPARMPYISDKHPRQTLEVINLLRKHRELCDVVLVVGAKKIY
SQ  AHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDERAMELLIDFAYTSQITVEEGNVQTSLPAACLLQLAEIQEACCEF
SQ  LKRQLDPSNCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWV
SQ  KYSIQERRPQLPQVLQHVRLPLLSTKFLVGTVGSDPLIKSDEECRDLVDEAKNYLLLPQERPLMQGPRTRPRKPIRCGEV
SQ  LFAVGGWCSGDAISSVERYDPQTNEWRMVASMSKRRCGVGVSVLDDLLYAVGGHDGSSYLNSVERYDPKTNQWSSDVAPT
SQ  STCRTSVGVAVLGGYLYAVGGQDGVSCLNIVERYDPKENKWTRVASMSTRRLGVAVAVLGGFLYAVGGSDGTSPLNTVER
SQ  YNPQENRWHTIAPMGTRRKHLGCAVYQDMIYAVGGRDDTTELSSAERYNPRTNQWSPVVAMTSRRSGVGLAVVNGQLMAV
SQ  GGFDGTTYLKTIEVFDPDANTWRLYGGMNYRRLGGGVGVIKMTHCESHIW
//