ID  Q5ZSQ2;
PN  Adenosine monophosphate-protein hydrolase SidD;
GN  sidD;
OS  272624;
SL  Nucleus Position: SL-0382;
SL  Comments: Host cytoplasm, host perinuclear region {ECO:0000269|PubMed:21680813}.
DR  UNIPROT: Q5ZSQ2;
DR  PDB: 4IIK;
DR  PDB: 4IIP;
DR  PDB: 6RP4;
DR  PDB: 6RRE;
DE  Function: Virulence effector that plays a role in hijacking the host vesicular trafficking by recruiting the small guanosine triphosphatase (GTPase) Rab1 to the cytosolic face of the Legionella-containing vacuole (LCVs). Acts as an adenosine monophosphate-protein hydrolase (de-AMPylase) by mediating the hydrolysis of adenosine 5'-monophosphate (AMP) to 'Tyr-77' of host RAB1B, thereby releasing RAB1B from bacterial phagosomes and rendering RAB1B accessible for inactivation by LepB. De- AMPylation of RAB1B cannot take place when LidA is bound to RAB1B. {ECO:0000269|PubMed:21680813, ECO:0000269|PubMed:21734656, ECO:0000269|PubMed:22228731}.
DE  Reference Proteome: Yes;
GO  GO:0044220;
GO  GO:0046872;
GO  GO:0044603;
GO  GO:0031267;
GO  GO:0018117;
GO  GO:0044602;
GO  GO:0043087;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MVYYEIIKDIVFTYNLQFTHLIHNDRISEVNLGGVTMRSIITQICNGVLHGQSYQSGSNDLDKGNSEIFASSLFVHLNEQ
SQ  GKEIIKHKDSDDKIVIGYTKDGMAFQIVVDGFYGCERQAVFSFIDNYVLPLIDNFSLDLTRYPDSKKVTESLIHTIYSLR
SQ  SKHAPLAEFTMSLCVTYQKDEQLFCAGFGIGDTGIAIKRNEGTIEQLVCHTEVDGFKDAFDNYSSANIDLVIERNSVFNT
SQ  KVMPGDELVGYTYVPPMLEMTEKEFEVETVDGKKINKRIVRHLNLDPGNFDDKDPLFSQLLQVVKSKQKQLVEQAKETGQ
SQ  IQRFGDDFTVGRLVIPDQLLINQLRIHALSIGVSDGLLSYIKNENENKGFLGIYGFFTGADKNIEKATLYKNLIAKYQNN
SQ  HFISLIILSALVSDSKTPLMTQYLVGYLDFPSKALLANKITELLLKELENPDMREILGSRLATDVIEELETKIIRYIHNP
SQ  AGSDIHSTLNLWTADKIKAATNSSLTI
//