ID  Q60664;
PN  Processed inositol 1,4,5-triphosphate receptor associated 2;
GN  Irag2;
OS  10090;
SL  Nucleus Position: SL-0178;
SL  Comments: [Processed inositol 1,4,5-triphosphate receptor associated 2]: Cytoplasm {ECO:0000269|PubMed:8798562}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:20071408}; Single-pass type IV membrane protein {ECO:0000255}. Nucleus envelope {ECO:0000305|PubMed:29878215}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q5RHB5}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250|UniProtKB:Q5RHB5}. Chromosome {ECO:0000250|UniProtKB:Q5RHB5}. Note=Colocalized with ITPR3 on the endoplasmic reticulum membrane. {ECO:0000269|PubMed:20071408}.
DR  UNIPROT: Q60664;
DR  UNIPROT: Q7TMU8;
DR  Pfam: PF05781;
DE  Function: Plays a role in the delivery of peptides to major histocompatibility complex (MHC) class I molecules; this occurs in a transporter associated with antigen processing (TAP)-independent manner. May play a role in taste signal transduction via ITPR3. May play a role during fertilization in pronucleus congression and fusion (PubMed:9314557). Plays a role in maintaining nuclear shape, maybe as a component of the LINC complex and through interaction with microtubules (PubMed:29878215). {ECO:0000269|PubMed:29878215, ECO:0000269|PubMed:9314557}.
DE  Reference Proteome: Yes;
DE  Interaction: A3KGF7; IntAct: EBI-688126; Score: 0.37
DE  Interaction: P70227; IntAct: EBI-9212709; Score: 0.27
DE  Interaction: Q63269; IntAct: EBI-9212784; Score: 0.46
DE  Interaction: E9Q401; IntAct: EBI-20567306; Score: 0.35
GO  GO:0005694;
GO  GO:0005783;
GO  GO:0005789;
GO  GO:0030176;
GO  GO:0005815;
GO  GO:0005635;
GO  GO:0000922;
GO  GO:0008017;
GO  GO:0002376;
GO  GO:0006997;
GO  GO:0007338;
TP  Membrane Topology: Transmembrane; Source: UniProt - Sequence Analysis {ECO:0000255};
SQ  MLCVKGPPEQEPEDGALDVTRGCQCPLPTEDSILGQELLDCTRMNEDQSTDENGAGHFYSESPSQLREYLTQPSSEQTSS
SQ  SESTVTSSESGSDILHMASGDLDCKPLCEKEEEARAASAMQGTSLAPAAYGDYTSVGVAKAASQLEAGEELRTTENGGKG
SQ  SAPGETEISMPPKASVKLVNFQQSENTSANEKEVEAEFLRLSLGLKCDWFTLEKRVKLEERSRDLAEENLKKEITNCLKL
SQ  LESLTPLCEEDNQAQEIVKKLEKSIVLLSQCTARVASRAEMLGAINQESRVSRAVEVMIQHVENLKRMYAKEHAELEDLK
SQ  QALLQNDRSFNSLPDEDDCQIKKRSSSLNSKPSSLRRVTIASLPRNLGNVGLVSGMENNDRFSRRSSSWRILGTKQGEHR
SQ  PSLHRFISTYSWADAEDERSDVKARDAPEPQGEEAVERTRKPSLSERRSSTLAWDRGTICSSVASWVTHLQASFRRANRA
SQ  LWLTGLIIILIAALMSFLTGQLFQTAVEAAPTQEGDSWLSLEHILWPFTRLGHDGPPPV
//