ID  Q61107;
PN  Guanylate-binding protein 4;
GN  Gbp4;
OS  10090;
SL  Nucleus Position: SL-0198;
SL  Comments: Cytoplasm {ECO:0000250|UniProtKB:Q96PP9}. Nucleus {ECO:0000250|UniProtKB:Q96PP9}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q96PP9}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q96PP9}. Note=Heterodimers with GBP1, GBP2 and GBP5 localize in the compartment of the prenylated GBPs: with GBP1 in a vesicle-like compartment, with GBP2, around the nucleus and with GBP-5, at the Golgi apparatus. {ECO:0000250|UniProtKB:Q96PP9}.
DR  UNIPROT: Q61107;
DR  UNIPROT: Q8VEC5;
DR  Pfam: PF02263;
DR  Pfam: PF02841;
DR  PROSITE: PS51715;
DE  Function: Binds GTP, GDP and GMP. Hydrolyzes GTP very efficiently; GDP rather than GMP is the major reaction product. Plays a role in erythroid differentiation. {ECO:0000269|PubMed:9659399}.
DE  Reference Proteome: Yes;
GO  GO:0031410;
GO  GO:0005829;
GO  GO:0005794;
GO  GO:0000139;
GO  GO:0005634;
GO  GO:0048471;
GO  GO:0005886;
GO  GO:0020005;
GO  GO:0005525;
GO  GO:0003924;
GO  GO:0042802;
GO  GO:0042803;
GO  GO:0044406;
GO  GO:0035458;
GO  GO:0071346;
GO  GO:0071356;
GO  GO:0050830;
GO  GO:0042832;
GO  GO:0051607;
GO  GO:0001818;
GO  GO:0046426;
GO  GO:0032480;
GO  GO:0034345;
GO  GO:0045070;
GO  GO:0043122;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MEAPICLVENWKNQLTVNLEAIRILEQIAQPLVVVAIVGLYRTGKSYLMNRLAGRNHGFSLGSTVQSETKGIWMWCVPHP
SQ  TKPTHTLVLLDTEGLGDVEKGDPKNDSWIFALAVLLSSTFVYNSMSTINQQALEQLHFVTELTQLIRAKSSPREDKVKDS
SQ  SEFVGFFPDFIWAVRDFALELKLNGRPITEDEYLENALKLIQGDNLKVQQSNMTRECIRYFFPVRKCFVFDRPTSDKRLL
SQ  LQIENVPENQLERNFQVESEKFCSYIFTNGKTKTLRGGVIVTGNRLGTLVQTYVNAINSGTVPCLENAVTTLAQRENSIA
SQ  VQKAADHYSEQMAQRMRLPTDTLQELLTVHAACEKEAIAVFMEHSFKDDEQEFQKKLVVTIEERKEEFIRQNEAASIRHC
SQ  QAELERLSESLRKSISCGAFSVPGGHSLYLEARKKIELGYQQVLRKGVKAKEVLKSFLQSQAIMEDSILQSDKALTDGER
SQ  AIAAERTKKEVAEKELELLRQRQKEQEQVMEAQERSFRENIAKLQEKMESEKEMLLREQEKMLEHKLKVQEELLIEGFRE
SQ  KSDMLKNEISHLREEMERTRRKPSLFGQILDTIGNAFIMILPGAGKLFGVGLKFLGSLSS
//