ID  Q61W58;
PN  Heat shock protein 90;
GN  daf;
OS  6238;
SL  Nucleus Position: SL-0198;
SL  Comments: Cytoplasm, perinuclear region. Note=Perinuclear region of somatic cells. {ECO:0000250}.
DR  UNIPROT: Q61W58;
DR  UNIPROT: A8WXX6;
DR  Pfam: PF02518;
DR  Pfam: PF00183;
DE  Function: Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. By stabilizing the receptor-type guanylate cyclase daf-11 or another signal transduction component that regulates cGMP levels, plays a role in dauer formation and chemotaxis to non-volatile and volatile attractants detected by AWC sensory neurons. Participates in the control of cell cycle progression at the prophase/metaphase transition in oocyte development by ensuring the activity of wee-1.3 kinase, which negatively regulates cdk-1 through its phosphorylation. Regulates yap-1 nuclear export after heat shock treatment. {ECO:0000250|UniProtKB:Q18688}.
DE  Reference Proteome: Yes;
GO  GO:0005829;
GO  GO:1990565;
GO  GO:0048471;
GO  GO:0005886;
GO  GO:0032991;
GO  GO:0005524;
GO  GO:0016887;
GO  GO:0140662;
GO  GO:0097718;
GO  GO:0042802;
GO  GO:0035259;
GO  GO:1990634;
GO  GO:0051082;
GO  GO:0007049;
GO  GO:0034605;
GO  GO:0061077;
GO  GO:0006935;
GO  GO:0040024;
GO  GO:0050829;
GO  GO:0008340;
GO  GO:0032516;
GO  GO:0006470;
GO  GO:0006611;
GO  GO:0006457;
GO  GO:0050821;
GO  GO:0050920;
GO  GO:0045859;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MSENAETFAFQAEIAQLMSLIINTFYSNKEIYLRELISNASDALDKIRYQALTEPSELDTGKELFIKITPNKEEKTLTIM
SQ  DTGIGMTKADLVNNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAFLVADKVVVTSKNNDDDSYQWESSAGGSFVV
SQ  RPYNDPELTRGTKITMYIKEDQVDFLEERKIKEIVKKHSQFIGYPIKLVVEKEREKEVEDEEAVESKDEEKKEGDVENVG
SQ  EDADAEKDKKKTKKIKEKYFEDEELNKTKPIWTRNPDDISNEEYAEFYKSLSNDWEDHLAVKHFSVEGQLEFRALLFAPQ
SQ  RAPFDLFENKKSKNSIKLYVRRVFIMENCEELMPEYLNFIKGVVDSEDLPLNISREMLQQSKILKVIRKNLVKKCMELFD
SQ  EIAEDKDNFKKFYEQFGKNLKLGIHEDSTNRKKLSEFLRYATSAGEEPTSLKEYVSRMKENQTQIYYITGESKEVVAASA
SQ  FVERVKSRGFEVLYMCDPIDEYCVQQLKEYDGKKLVSVTKEGLELPETEEEKKKFEEDKVAYENLCKVIKDILEKKIEKV
SQ  AVSNRLVSSPCCIVTSEYGWSANMERIMKAQALRDSSTMGYMAAKKHLEINPDHAIMKTLRERVEADKNDKTVKDLVVLL
SQ  FETALLSSGFSLEEPQSHASRIYRMIKLGLDIGDEDIEESAVPSSCTAEAKIEGADEDASRMEEVD
//