ID Q63358; PN Unconventional myosin-IXb; GN Myo9b; OS 10116; SL Nucleus Position: SL-0198; SL Comments: Cytoplasm, cell cortex {ECO:0000250|UniProtKB:Q13459}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q13459}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q13459}. Note=In undifferentiated cells colocalizes with F-actin in the cell periphery while in differentiated cells its localization is cytoplasmic with the highest levels in the perinuclear region. {ECO:0000250|UniProtKB:Q13459}. DR UNIPROT: Q63358; DR Pfam: PF00612; DR Pfam: PF00063; DR Pfam: PF00788; DR Pfam: PF00620; DR PROSITE: PS50096; DR PROSITE: PS51456; DR PROSITE: PS50200; DR PROSITE: PS50238; DR PROSITE: PS00479; DR PROSITE: PS50081; DE Function: Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Binds actin with high affinity both in the absence and presence of ATP and its mechanochemical activity is inhibited by calcium ions (By similarity). Also acts as a GTPase activator for RHOA (PubMed:7882973). Plays a role in the regulation of cell migration via its role as RHOA GTPase activator. This is regulated by its interaction with the SLIT2 receptor ROBO1; interaction with ROBO1 impairs interaction with RHOA and subsequent activation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA (By similarity). {ECO:0000250|UniProtKB:Q13459, ECO:0000269|PubMed:7882973}. DE Reference Proteome: Yes; DE Interaction: D4A631; IntAct: EBI-6251135; Score: 0.51 DE Interaction: P35658; IntAct: EBI-25412031; Score: 0.35 DE Interaction: P78406; IntAct: EBI-25412031; Score: 0.35 DE Interaction: P51571; IntAct: EBI-25412031; Score: 0.35 DE Interaction: P28074; IntAct: EBI-25412031; Score: 0.35 DE Interaction: O14818; IntAct: EBI-25412031; Score: 0.35 DE Interaction: Q9H3U1; IntAct: EBI-25412031; Score: 0.35 DE Interaction: Q9NZ01; IntAct: EBI-25412031; Score: 0.35 DE Interaction: Q6NUK1; IntAct: EBI-25412031; Score: 0.35 DE Interaction: P28070; IntAct: EBI-25412031; Score: 0.35 DE Interaction: P49721; IntAct: EBI-25412031; Score: 0.35 DE Interaction: P25786; IntAct: EBI-25412031; Score: 0.35 DE Interaction: Q13765; IntAct: EBI-25412031; Score: 0.35 DE Interaction: P14649; IntAct: EBI-25412031; Score: 0.35 DE Interaction: P07195; IntAct: EBI-25412031; Score: 0.35 DE Interaction: P84077; IntAct: EBI-25412031; Score: 0.35 GO GO:0005884; GO GO:0005938; GO GO:0005737; GO GO:0005829; GO GO:0032433; GO GO:0030027; GO GO:0016459; GO GO:0048471; GO GO:0001726; GO GO:0003779; GO GO:0051015; GO GO:0043531; GO GO:0005524; GO GO:0016887; GO GO:0043008; GO GO:0005516; GO GO:0005096; GO GO:0000146; GO GO:0048495; GO GO:0031267; GO GO:0008270; GO GO:0030048; GO GO:0030010; GO GO:0072673; GO GO:0048246; GO GO:0002548; GO GO:0043547; GO GO:0035023; GO GO:0007266; GO GO:0035385; TP Membrane Topology: Unknown; Source: UniProt - Sequence Analysis; SQ MSAHEAGSSGRRRPATFHLHIYPQLPSAGSQTSCRVTATKDSTTSDVIRDVVASLHLDGSKHYVLVEVKESGGEEWVLDA SQ SDSPVHRVLLWPRRAQKEHPREDGYYFLLQERNADGSIQYLHVQLLAQPTAACRLVERGLLPRPQADFDDLCNLPELNEA SQ NLLQSLKLRFVQQKIYTYAGSILVAINPFKFLPIYNPKYVKMYENQQLGKLEPHVFALADVAYYTMLRKHVNQCIVISGE SQ SGSGKTQSTNFLIHCLTALSQKGYASGVERTILGAGPVLEAFGNAKTAHNNNSSRFGKFIQVNYLESGIVRGAVVEKYLL SQ EKSRLVSQEKDERNYHVFYYLLLGVSEEERQEFQLKQPQDYFYLNQHNLNIEDGEDLKHDFERLQQAMEMVGFLPATKKQ SQ IFSVLSAILYLGNVTYKKRATGRDEGLEVGPPEVLDTLSQLLKVKRETLVEVLTKRKTITVNDKLILPYSLSEAITARDS SQ MAKSLYSALFDWIVLRINHALLNKKDMEEAVSCLSIGVLDIFGFEDFERNSFEQFCINYANEQLQYYFTQHIFKLEQEEY SQ QGEGISWHNIDYTDNVGCIHLISKKPTGLFYLLDEESNFPHATSHTLLAKFKQQHEDNKYFLGTPVLEPAFIIQHFAGRV SQ KYQIKDFREKNMDYMRPDIVALLRGSDSSYVRQLIGMDPVAVFRWAVLRAAIRAMAVLREAGRLRAERAEKAEAGVSSPV SQ TRSHVEELPRGANTPSEKLYRDLHNQIIKSLKGLPWQGEDPRRLLQSLSRLQKPRTFFLKSKGIKQKQIIPKNLLDSKSL SQ RLIISMTLHDRTTKSLLHLHKKKKPPSISAQFQTSLNKLLEALGKAEPFFIRCIRSNAEKKELCFDDELVLQQLRYTGML SQ ETVRIRRSGYSAKYTFQDFTEQFQVLLPKDVQPCREAIAALLEKLQVDRQNYQIGKTKVFLKETERQALQERLHGEVLRR SQ ILLLQSWFRMVLERRHFVQMKHAALTIQACWRSYRVRRTLERTRAAVYLQAAWRGYLQRQAYHHQRHSIIRLQSLCRGHL SQ QRRSFSQMMLEKQKAEQARETAGAEMSEGEPSPVAAGEQPSEHPVEDPESLGVETETWMNSKSPNGLSPKKEIPSPEMET SQ PAQKTVPAESHEKVPSSREKRESRRQRGLEHVERQNKHIQSCREENSTLREPSRKASLETGESFPEDTKEPREDGLETWT SQ ETAAPSCPKQVPIVGDPPRSPSPLQRPASLDLDSRVSPVLPSSSLESPQDEDKGENSTKVQDKPESPSGSTQIQRYQHPD SQ TERLATAVEIWRGKKLASAMLSQSLDLSEKPRTAGAALTPTEERRISFSTSDVSKLSPVKTSTEVDGDLSAKKPAGHKKK SQ SEDPSAGPDAGLPTGSQGDSKSAFKRLFLHKAKDKKPSLEGVEETEGSGGQAAQEAPARKTLDVPSSQQHRHTTGEKPLK SQ GKKNRNRKVGQITVSEKWRESVFRKITNANELKFLDEFLLNKVNDLRSQKTPIESLFIEATERFRSNIKTMYSVPNGKIH SQ VGYKDLMENYQIVVSNLAAERGEKDTNLVLNVFQSLLDEFTRSYNKTDFEPVKGKAQKKKRKQERAVQEHNGHVFASYQV SQ NIPQSCEQCLSYIWLMDKALLCSVCKMTCHKKCVHKIQSYCSYTGRRKSELGAEPGHFGVCVDSLTSDKASVPIVLEKLL SQ EHVEMHGLYTEGLYRKSGAANRTRELRQALQTDPATVKLEDFPIHAITGVLKQWLRELPEPLMTFAQYGDFLRAVELPEK SQ QEQLAAIYAVLDHLPEANHTSLERLIFHLVKVALLEDVNRMSPGALAIIFAPCLLRCPDNSDPLTSMKDVLKITTCVEML SQ IKEQMRKYKVKMEEINHLEAAESIAFRRLSLLRQNAPWPLKLGFSSPYEGVRTKSPRTPVVQDLEELGALPEEAAGGDED SQ REKEILMERIQSIKEEKEDITYRLPELDPRGSDEENLDSETSASTESLLEERAVRGAAEE //