ID  Q63481;
PN  Ras-related protein Rab-7L1;
GN  Rab29;
OS  10116;
SL  Nucleus Position: SL-0198;
SL  Comments: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cytoplasm {ECO:0000250|UniProtKB:O14966}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:O14966}. Golgi apparatus {ECO:0000269|PubMed:23395371}. Golgi apparatus, trans-Golgi network {ECO:0000250|UniProtKB:O14966}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:23395371}. Note=Colocalizes with GM130 at the Golgi apparatus (By similarity). Colocalizes with dynamic tubules emerging from and retracting to the Golgi apparatus (By similarity). Colocalizes with TGN46 at the trans-Golgi network (TGN) (By similarity). Colocalized with LRRK2 along tubular structures emerging from Golgi apparatus (PubMed:23395371). {ECO:0000250|UniProtKB:O14966, ECO:0000269|PubMed:23395371}.
DR  UNIPROT: Q63481;
DR  Pfam: PF00071;
DR  PROSITE: PS51419;
DE  Function: The small GTPases Rab are key regulators in vesicle trafficking (PubMed:23395371). Essential for maintaining the integrity of endosome-trans-Golgi network structure (PubMed:23395371). Together with LRRK2, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner (PubMed:23395371). Recruits LRRK2 to the Golgi apparatus and stimulates LRRK2 kinase activity (By similarity). Regulates also neuronal process morphology in the intact central nervous system (CNS) (PubMed:23395371). {ECO:0000250|UniProtKB:O14966, ECO:0000269|PubMed:23395371}.
DE  Reference Proteome: Yes;
DE  Interaction: Q5S007; IntAct: EBI-6514548; Score: 0.46
DE  Interaction: Q08484; IntAct: EBI-15592913; Score: 0.44
GO  GO:0005801;
GO  GO:0005737;
GO  GO:0005856;
GO  GO:0005829;
GO  GO:0005769;
GO  GO:0005794;
GO  GO:0097708;
GO  GO:0042470;
GO  GO:0005739;
GO  GO:0048471;
GO  GO:0005886;
GO  GO:0055037;
GO  GO:0005802;
GO  GO:0005773;
GO  GO:0031982;
GO  GO:0070840;
GO  GO:0019003;
GO  GO:0005525;
GO  GO:0003924;
GO  GO:0019894;
GO  GO:0031267;
GO  GO:0030154;
GO  GO:0060271;
GO  GO:0007030;
GO  GO:0006886;
GO  GO:0032438;
GO  GO:0007005;
GO  GO:0044788;
GO  GO:0010977;
GO  GO:0090316;
GO  GO:0001921;
GO  GO:0050862;
GO  GO:1903441;
GO  GO:0072657;
GO  GO:1901214;
GO  GO:1905279;
GO  GO:0009617;
GO  GO:0042147;
GO  GO:0007416;
GO  GO:0042110;
GO  GO:1901998;
GO  GO:0039694;
TP  Membrane Topology: Lipid-Anchored; Source: UniProt - By Similarity {ECO:0000250};
SQ  MGSRDHLFKVLVVGDAAVGKTSLVQRYSQDSFSKHYKSTVGVDFALKVLQWSDSEMVRLQLWDIAGQERFTSMTRLYYRD
SQ  ASACVIMFDVTNATTFSNSQRWKQDLDSKLTLPSGEPVPCLLLANKSDLSPWAVSRDQIDRFSKENGFTGWTETSVKENK
SQ  NINEAMRVLVEKMMNNSREDIMSSSTQGNYINLQTKPSPGWTCC
//