ID  Q63850;
PN  Nuclear pore glycoprotein p62;
GN  Nup62;
OS  10090;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0185;
SL  Comments: Nucleus, nuclear pore complex {ECO:0000250|UniProtKB:P37198}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250|UniProtKB:P37198}. Nucleus envelope {ECO:0000250|UniProtKB:P37198}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:P37198}. Note=Central region of the nuclear pore, within the transporter. During mitotic cell division, it associates with the poles of the mitotic spindle. {ECO:0000250|UniProtKB:P37198}.
DR  UNIPROT: Q63850;
DR  UNIPROT: Q99JN7;
DR  Pfam: PF05064;
DE  Function: Essential component of the nuclear pore complex. The N- terminal is probably involved in nucleocytoplasmic transport. The C- terminal is involved in protein-protein interaction probably via coiled-coil formation, promotes its association with centrosomes and may function in anchorage of p62 to the pore complex. Plays a role in mitotic cell cycle progression by regulating centrosome segregation, centriole maturation and spindle orientation. It might be involved in protein recruitment to the centrosome after nuclear breakdown. {ECO:0000250|UniProtKB:P37198}.
DE  Reference Proteome: Yes;
DE  Interaction: Q9NRI5; IntAct: EBI-26612017; Score: 0.35
GO  GO:0005642;
GO  GO:0005813;
GO  GO:0005737;
GO  GO:0090543;
GO  GO:0072686;
GO  GO:0005635;
GO  GO:0031965;
GO  GO:0005643;
GO  GO:0044613;
GO  GO:0005654;
GO  GO:0032991;
GO  GO:1990904;
GO  GO:0000922;
GO  GO:0030544;
GO  GO:0051879;
GO  GO:0019894;
GO  GO:0046966;
GO  GO:0005543;
GO  GO:0044877;
GO  GO:0051425;
GO  GO:0042169;
GO  GO:0030159;
GO  GO:0017056;
GO  GO:0043130;
GO  GO:0008219;
GO  GO:0016477;
GO  GO:0007166;
GO  GO:0090398;
GO  GO:0098534;
GO  GO:0007098;
GO  GO:0000278;
GO  GO:0007100;
GO  GO:0007080;
GO  GO:0051028;
GO  GO:0043066;
GO  GO:0008285;
GO  GO:0042059;
GO  GO:0043407;
GO  GO:0043069;
GO  GO:0046580;
GO  GO:0006913;
GO  GO:0046601;
GO  GO:0045893;
GO  GO:0043123;
GO  GO:1903438;
GO  GO:0045840;
GO  GO:1904781;
GO  GO:0006606;
GO  GO:0060236;
GO  GO:0042306;
GO  GO:0006405;
GO  GO:0007283;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MSGFNFGGTGAPAGGFTFGTAKTATTTPATGFSFSASGTGTGGFNFGTPSQPAATTPSTSLFSLTTQTPTTQTPGFNFGT
SQ  TPASGGTGFSLGISTPKLSLSNAAATPATANTGSFGLGSSTLTNAISSGSTSNQGTAPTGFVFGSSTTSAPSTGSTGFSF
SQ  TSGSASQPGASGFSLGSVGSSAQPTALSGSPFTPATLVTTTAGATQPAAAAPTAATTSAGSTLFASIAAAPASSSATGLS
SQ  LPAPVTTAATPSAGTLGFSLKAPGAAPGASTTSTTTTTTTTTTTAAAAAASTTTTGFALSLKPLVSAGPSSVAATALPAS
SQ  STAAGTATGPAMTYAQLESLINKWSLELEDQERHFLQQATQVNAWDRTLIENGEKITSLHREVEKVKLDQKRLDQELDFI
SQ  LSQQKELEDLLSPLEESVKEQSGTIYLQHADEEREKTYKLAENIDAQLKRMAQDLKDIIEHLNMAGGPADTSDPLQQICK
SQ  ILNAHMDSLQWVDQSSALLQRRVEEASRVCEGRRKEQERSLRIAFD
//