ID  Q640M6;
PN  Glycerophosphodiester phosphodiesterase domain-containing protein 5;
GN  Gdpd5;
OS  10090;
SL  Nucleus Position: SL-0198;
SL  Comments: Endomembrane system {ECO:0000269|PubMed:17275818, ECO:0000269|PubMed:18667693, ECO:0000305|PubMed:15276213}; Multi-pass membrane protein {ECO:0000255}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:15276213, ECO:0000269|PubMed:17275818, ECO:0000269|PubMed:18667693}. Cell projection, growth cone {ECO:0000269|PubMed:17275818}.
DR  UNIPROT: Q640M6;
DR  UNIPROT: Q8R0T5;
DR  UNIPROT: Q8R3N5;
DR  Pfam: PF03009;
DR  PROSITE: PS51704;
DE  Function: Glycerophosphodiester phosphodiesterase that promotes neurite formation and drives spinal motor neuron differentiation (PubMed:17275818, PubMed:18667693). Mediates the cleavage of glycosylphosphatidylinositol (GPI) anchor of target proteins: removes the GPI-anchor of RECK, leading to release RECK from the plasma membrane (By similarity). May contribute to the osmotic regulation of cellular glycerophosphocholine (PubMed:18667693). {ECO:0000250|UniProtKB:Q3KTM2, ECO:0000269|PubMed:17275818, ECO:0000269|PubMed:18667693}.
DE  Reference Proteome: Yes;
GO  GO:0030424;
GO  GO:0005789;
GO  GO:0030426;
GO  GO:0016021;
GO  GO:0016020;
GO  GO:0043025;
GO  GO:0097038;
GO  GO:0005886;
GO  GO:0047389;
GO  GO:0008889;
GO  GO:0004435;
GO  GO:0021895;
GO  GO:0006629;
GO  GO:0045746;
GO  GO:0030182;
GO  GO:0031175;
GO  GO:0007219;
GO  GO:0045787;
GO  GO:0045666;
GO  GO:0048505;
GO  GO:0021522;
TP  Membrane Topology: Transmembrane; Source: UniProt - Sequence Analysis {ECO:0000255};
SQ  MVRHQPLQYYEPQLCLSCLTGIYGCRWKRYQRSHDDTTPWERLWFLLLVCTFSLTLTWLYFWWGVHNDYDEFNWYLYNRM
SQ  GYWSDWSVPILVTSAAAFTYIAGLLVLALCHIAVGQQLNLHWIHKMGLVVILASTVVAMSAVAQLWEDEWEVLLISLQGT
SQ  APFLHIGALVAITALSWIVAGQFARAERSSSQLTILCTFFAVVFTFYLIPLTISSPCIMEKKDLGPKPALIGHRGAPMLA
SQ  PEHTVMSFRKALEQRLYGLQADITISLDGVPFLMHDTTLRRTTNVEHLFPELARRPAAMLNWTVLQRLNAGQWFLKTDPF
SQ  WTASSLSPSDHREVQNQSICSLAELLELAKGNASLLLNLRDPPRDHPYRGSFLNVTLEAVLRSGFPQHQVMWLFNRQRPL
SQ  VRKMAPGFQQTSGSKEAIANLRKGHIQKLNLRYTQVSHQELRDYASWNLSVNLYTVNAPWLFSLLWCAGVPSVTSDNSHT
SQ  LSRVPSPLWIMPPDEYCLMWVTADLISFSLIIGIFVLQKWRLGGIRSYNPEQIMLSAAVRRTSRDVSIMKEKLIFSEISD
SQ  GVEVSDELSVCSDSSYDTYANANSTATPVGPRNAGSRAKTVTEQSGH
//