ID  Q645J3;
PN  Sigma non-opioid intracellular receptor 1;
GN  SIGMAR1;
OS  8321;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0179;
SL  Nucleus Position: SL-0182;
SL  Nucleus Position: SL-0183;
SL  Comments: Nucleus inner membrane {ECO:0000250|UniProtKB:Q99720}. Nucleus outer membrane {ECO:0000250|UniProtKB:Q99720}. Nucleus envelope {ECO:0000250|UniProtKB:Q99720}. Cytoplasmic vesicle {ECO:0000250|UniProtKB:Q99720}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q99720}. Membrane {ECO:0000250|UniProtKB:Q99720}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q99720}. Note=During interphase, detected at the inner and outer nuclear membrane and the endoplasmic reticulum. Detected on cytoplasmic vesicles during mitosis (By similarity). Targeted to lipid droplets, cholesterol and galactosylceramide-enriched domains of the endoplasmic reticulum (By similarity). {ECO:0000250|UniProtKB:O55242, ECO:0000250|UniProtKB:Q99720}.
DR  UNIPROT: Q645J3;
DR  Pfam: PF04622;
DE  Function: May function in lipid transport from the endoplasmic reticulum and be involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. May regulate calcium efflux at the endoplasmic reticulum (By similarity). {ECO:0000250}.
DE  Reference Proteome: No;
GO  GO:0031410;
GO  GO:0005789;
GO  GO:0016021;
GO  GO:0005637;
GO  GO:0005640;
GO  GO:0006869;
TP  Membrane Topology: Transmembrane; Source: UniProt - By Similarity {ECO:0000250|UniProtKB:Q99720};
SQ  MAVLSSRAMRAALGLAVLAVVIQLLRTWLSSKSYLFNQKDIAELAKQHAGMDFEVAFSKIIVELRKKHPGHILPDEDLQW
SQ  IFVNAGGWMGSMCLLHASLTEYILLFGTAIDTGGHSGRYWADISDTVITGTFRQWKEGTTKSEVFYPGDTIVHVAGEATS
SQ  VHWSGGTWMVEYGRGFIPSTMGFALADTIFSTQDFCTLFYTFRIYARCLLLETHTYLSELGLS
//