ID  Q66T02;
PN  Pleckstrin homology domain-containing family G member 5;
GN  Plekhg5;
OS  10090;
SL  Nucleus Position: SL-0198;
SL  Comments: Cytoplasm {ECO:0000269|PubMed:16467373}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:16467373}. Cell membrane {ECO:0000269|PubMed:16467373}. Cell junction {ECO:0000269|PubMed:21543326}. Cell projection, lamellipodium {ECO:0000269|PubMed:21543326}. Note=Predominantly cytoplasmic, however when endothelial cells are stimulated with lysophosphatidic acid, PLEKHG5 is found in perinuclear regions and at the cell membrane (PubMed:16467373). Localizes at cell-cell junctions in quiescent endothelial cells, and relocalizes to cytoplasmic vesicle and the leading edge of lamellipodia in migrating endothelial cells (PubMed:21543326). {ECO:0000269|PubMed:16467373, ECO:0000269|PubMed:21543326}.
DR  UNIPROT: Q66T02;
DR  UNIPROT: A2A8B6;
DR  UNIPROT: A2A8B7;
DR  UNIPROT: Q66T00;
DR  UNIPROT: Q6P3B1;
DR  UNIPROT: Q6ZQ62;
DR  UNIPROT: Q8R571;
DR  Pfam: PF00621;
DR  PROSITE: PS50010;
DR  PROSITE: PS50003;
DE  Function: Functions as a guanine exchange factor (GEF) for RAB26 and thus regulates autophagy of synaptic vesicles in axon terminal of motoneurons (PubMed:29084947). Involved in the control of neuronal cell differentiation. Plays a role in angiogenesis through regulation of endothelial cells chemotaxis (PubMed:21543326). Affects also the migration, adhesion, and matrix/bone degradation in macrophages and osteoclasts (By similarity). {ECO:0000250|UniProtKB:O94827, ECO:0000269|PubMed:21543326, ECO:0000269|PubMed:29084947}.
DE  Reference Proteome: Yes;
DE  Interaction: Q9Z254; IntAct: EBI-9079994; Score: 0.40
DE  Interaction: P02563; IntAct: EBI-9080038; Score: 0.40
DE  Interaction: P35294; IntAct: EBI-11567325; Score: 0.35
DE  Interaction: Q6PK04; IntAct: EBI-25409900; Score: 0.35
DE  Interaction: O75947; IntAct: EBI-25409900; Score: 0.35
DE  Interaction: P61586; IntAct: EBI-25409900; Score: 0.35
DE  Interaction: O75970; IntAct: EBI-25409900; Score: 0.35
DE  Interaction: Q9NUP9; IntAct: EBI-25409900; Score: 0.35
DE  Interaction: Q8NI35; IntAct: EBI-25409900; Score: 0.35
DE  Interaction: O14908; IntAct: EBI-25409900; Score: 0.35
GO  GO:0030424;
GO  GO:0005911;
GO  GO:0005737;
GO  GO:0030139;
GO  GO:0030027;
GO  GO:0048471;
GO  GO:0005886;
GO  GO:0098793;
GO  GO:0005085;
GO  GO:0035767;
GO  GO:0043542;
GO  GO:0099575;
GO  GO:0007266;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MGTGPGVSGRRAAARPSSELPSPDSQLLWVGGHAHSSDSQVCHHADCQQLHHRGPLNLCETCDSKFHSTLHYDGHVRFDL
SQ  PPQGSVLARNVSTRSCPPRTSPAADLEEEEEGCTDGKGDRKSAGLKISKKKARRRHTDDPSKECFTLKFDLNVDIETEIV
SQ  PAMKKKSLGEVLLPVFERKGIALGKVDIYLDQSNTPLSLTFEAYRFGGHYLRVKAKPGDEGKVEQGVKDSKSLSLPALRP
SQ  SGAGPPVSERVDPQSRRESSLDILAPGRRRKNMSEFLGEAGIPGHEPPAPSSCSLPVGSSGGTSSGINESWKNRAASRFS
SQ  GFFSSSPSTSAFSREVDKMEQLESKLHAYSLFGLPRMPRRLRFDHDSWEEEEEDDEEDEESSGLRLEDSWRELTDGHEKL
SQ  TRRQCHQQEAVWELLHTEVSYIRKLRVITNLFLCCLLNLQESGLLCEVEAERLFSNIPEIAKLHRGLWGSVMVPVLEKAR
SQ  RTRALLQPSDFLKGFKMFGSLFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYVTWAEKHQQCQRLKLSDMLAKPHQRLTK
SQ  YPLLLKSVLRKTDDPRTKEAIVTMISSVERFIHHVNTCMRQRQERQRLAGVVSRIDAYEVVEGSNDEVDKLLKEFLHLDL
SQ  TAPMPGTSPEETRQLLLEGSLRMKEGKDSKMDVYCFLFTDLLLVTKAVKKAERTKVIRPPLLVDKIVCRELRDPGSFLLI
SQ  YLNEFHSAVGAYTFQASSQALCRSWVDTIYNAQNQLQQLRAQLSAQEHPGSQHLQSLEEEEDEQEEEGEESGTSAASSPT
SQ  ILRKSSNSLDSEHCTSDGSTETLAMVVVEPGATLSSPEFEGGPVSSQSDESSLSNTASSVTPTSELLPLGPVDGRSCSMD
SQ  SAYGTLSPTSLQDFVAPHPVVEPAPVPQTPSPQPSPRLRRRTPVQLLPRPPRLLKSKSEASLLQLLSGTPAARGVPPAPS
SQ  RSLSELCLISVAPGVRTQRPLQEGGPGWNGPGMCDPCHGPQLSESENRPSHMTGGPADSARRRCREMPSGTMSRVQSEPP
SQ  SGVSAQHRKLTLAQLYRIRTTLLLNSTLTASEV
//