ID  Q68F64;
PN  Protein unc-45 homolog B;
GN  unc45b;
OS  8355;
SL  Nucleus Position: SL-0198;
SL  Comments: Cytoplasm, myofibril, sarcomere, Z line {ECO:0000250|UniProtKB:Q6DGE9}. Cytoplasm, myofibril, sarcomere, A band {ECO:0000250|UniProtKB:Q8IWX7}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q6DGE9}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q8CGY6}. Note=Expressed at the Z line and in the perinuclear region of myofibrils. Translocates to the A band in response to stress conditions and fibril damage. {ECO:0000250|UniProtKB:Q6DGE9}.
DR  UNIPROT: Q68F64;
DR  Pfam: PF13181;
DR  Pfam: PF11701;
DR  PROSITE: PS50005;
DR  PROSITE: PS50293;
DE  Function: Acts as a co-chaperone for HSP90 and is required for proper folding of the myosin motor domain. Plays a role in sarcomere formation during muscle cell assembly (By similarity). Is necessary for normal early lens development. {ECO:0000250|UniProtKB:D7REX8, ECO:0000250|UniProtKB:Q6DGE9, ECO:0000250|UniProtKB:Q8CGY6}.
DE  Reference Proteome: Yes;
GO  GO:0031672;
GO  GO:0005829;
GO  GO:0048471;
GO  GO:0030018;
GO  GO:0030154;
GO  GO:0002088;
GO  GO:0007517;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MEDPVQLKEEGNKYFQSNDYGNAIECYSKALKLITDKKMKAVLYRNRSACYLKQENYIQAAADASKAIDVDASDIKALFR
SQ  RCQALEKLGKLDQAYKDVQRCATLEPKNRTFLEMLHRLGSNIQEKLHVQFSTDSRVQKMFEILLDENSDKEKREKAANNL
SQ  IVLGREDAGAERIFQNNGVNLLMQLIETKDPELILSAVRTLSGMCTGHRARATAIVHLVGINKICSIMAVDHEEIALAAC
SQ  NLLQNIVDSLTGEDKKVHGKEEALVLDTKKDLKVITTHLLDMLVSKKVSGHGRDQALNLLNKNIPRYDLKNKDNSKTLFV
SQ  VDVGLKKILKVLGQVPELPNCLPLTPNTRLNASVLINKLYDDLRCDPERDDFRKICEEYITGSFDPKDMEKNLHAIQTVS
SQ  GILQGPFDLGNILLGMQGVMEMMVALTGSEKEVDQLVAVEALIHASTKLSRASFIITNGVSLLKDIYKKTKNEKIKIRAL
SQ  VGLCKLGSAGGTDYALRQFAEGSTDKLAKQCRKWLCNTSLDIQTRKWAVEGLAYLTLDADVKDEFVEDEQSLKAMFELCK
SQ  TSDKTILYSVATTLVNCTNSYDVKEVIPEMVQLAKFSKQHVPEQHPKDKKDFVLKRVKKLLQADVISALSCMVKADNSIL
SQ  TDQTKEQIARVFLALCDEPKDRGIIVAQGGGKAMIPLALEGTDVGKTKASHGLAKIAAVSNPDIAFPGERVYEVVRPLVS
SQ  LLNTERDGVQNFEALLALTNLSGKSDKLRQKIVKEKALPEIENYMFENHEQIRQAATECMCNLAVNKEVKERFTAEGNDR
SQ  LKLIVLLCGEDEEVKLQRAAAGTLAILTAAEKKLCHKMTEVTSQWLEILQRLCLNEDLQVQHRGVVITYNLISAEKELAK
SQ  KLVESEMLEILTVIGKQADVPNKQHIINVAREALVKCLDYGFIKTVS
//