ID  Q68FU1;
PN  Pleckstrin homology domain-containing family F member 1;
GN  Plekhf1;
OS  10116;
SL  Nucleus Position: SL-0198;
SL  Comments: Nucleus {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Lysosome {ECO:0000250}. Note=Translocates to lysosome during apoptosis. {ECO:0000250}.
DR  UNIPROT: Q68FU1;
DR  Pfam: PF01363;
DR  Pfam: PF00169;
DR  PROSITE: PS50003;
DR  PROSITE: PS50178;
DE  Function: May induce apoptosis through the lysosomal-mitochondrial pathway. Translocates to the lysosome initiating the permeabilization of lysosomal membrane (LMP) and resulting in the release of CTSD and CTSL to the cytoplasm. Triggers the caspase-independent apoptosis by altering mitochondrial membrane permeabilization (MMP) resulting in the release of PDCD8 (By similarity). {ECO:0000250}.
DE  Reference Proteome: Yes;
GO  GO:0005769;
GO  GO:0005764;
GO  GO:0005634;
GO  GO:0048471;
GO  GO:0046872;
GO  GO:0035091;
GO  GO:0032266;
GO  GO:0070273;
GO  GO:0010314;
GO  GO:0006915;
GO  GO:0007032;
GO  GO:0008333;
GO  GO:0010508;
GO  GO:2001244;
GO  GO:0072659;
GO  GO:0016050;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MVDHLANTEINSQRIAAVENCFGASGQPLALPGRVLLGEGVLTKECRKKAKPRIFFLFNDILVYGSIVLSKRKYRSQHII
SQ  PLEEVTLEPLPETLQAKNRWMIKTAKKSFVVSAASTTERQEWISHIEECVRRQLLATGRQPTTEHAAPWIPDKATDICMR
SQ  CTQTRFSALTRRHHCRKCGFVVCAECSRERFLLPRLSPKPLRVCSLCYRELAAQKRREEAKERFRGSPGQLTHLGSTMCG
SQ  ASSGDDDDSDEDREGSGDGDWPTQVEFYASGVSWSAFHS
//