ID  Q6AX31;
PN  Nucleoporin NDC1;
GN  ndc1;
OS  8355;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0182;
SL  Nucleus Position: SL-0185;
SL  Comments: Nucleus, nuclear pore complex {ECO:0000269|PubMed:16600873}. Nucleus membrane {ECO:0000269|PubMed:16600873}; Multi-pass membrane protein {ECO:0000269|PubMed:16600873}. Note=Central core structure of the nuclear pore complex.
DR  UNIPROT: Q6AX31;
DR  PDB: 7WKK;
DR  Pfam: PF09531;
DE  Function: Component of the nuclear pore complex (NPC), which plays a key role in de novo assembly and insertion of NPC in the nuclear envelope. Required for NPC and nuclear envelope assembly, possibly by forming a link between the nuclear envelope membrane and soluble nucleoporins, thereby anchoring the NPC in the membrane. {ECO:0000269|PubMed:16600873}.
DE  Reference Proteome: Yes;
GO  GO:0016021;
GO  GO:0031965;
GO  GO:0005643;
GO  GO:0051028;
GO  GO:0015031;
TP  Membrane Topology: Transmembrane; Source: UniProt - Sequence Analysis {ECO:0000255};
SQ  MTMLGERLVLRWRVAASFAWSVILMPVCCALFIVLSRIQILHPIQWLTDSISDLTSSYTIFCLLLICAILGLQCTFLMEY
SQ  YTVVPSIPCSRLALIGNLLLPHRILHSLAHVAMGVLASWCYAVLSKGKYQLLVVSCTLQSEDEADKPSHCLNESHLFQLL
SQ  CGAFFGYSYSLQYFVHNMNYLSFPSIQQYKYLQFRRFLPLIIKQSVFQSLYFIRSYAILYFCLGNIPRTWIQTALNLHMD
SQ  RQQPSLDTLRGFLNLSLFYQIWLSGTFLLATWYMVWILFRIYTTEARIFPVQTSFAEEAEKCLPFILNSNTLPLVKYLAM
SQ  QDLVLLSQYSPSRRQEVFSLSQPGGHPHNWTSISKECLNLMSSLTSRLIAHQEAAANNGRMRVPSSPKQIRKSSSSSGTS
SQ  LIEDSAEQTQNLSTIPRIGIPSLLKTASLKSSLDIGSPFATPGVKQMSESLDPNTPCHGSVQSPQVTRRGAKLWTSDSDV
SQ  QKNGSEVSPVMHRPVCNGAKQGILHTWFQHKLVQIKNVLSKRGLIMYLFSKHPEASSQDVFADAQIHIWALEALSHLVAA
SQ  SFSEDRMGVVQTSLSSVLAILLTLQEAVEKHFKLPHASSKPARNPGSLLDSSCKTLRFSLRAALKTAIYRITTTFGEHLH
SQ  AVPVSSEHKKKLQQFLDFKE
//