ID  Q6AYU3;
PN  DnaJ homolog subfamily B member 6;
GN  Dnajb6;
OS  10116;
SL  Nucleus Position: SL-0198;
SL  Comments: Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:O75190}. Nucleus {ECO:0000250|UniProtKB:O75190}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000250|UniProtKB:O75190}.
DR  UNIPROT: Q6AYU3;
DR  Pfam: PF00226;
DR  PROSITE: PS00636;
DR  PROSITE: PS50076;
DE  Function: Plays an indispensable role in the organization of KRT8/KRT18 filaments. Acts as an endogenous molecular chaperone for neuronal proteins including huntingtin. Suppresses aggregation and toxicity of polyglutamine-containing, aggregation-prone proteins (By similarity). Has a stimulatory effect on the ATPase activity of HSP70 in a dose- dependent and time-dependent manner and hence acts as a co-chaperone of HSP70. Also reduces cellular toxicity and caspase-3 activity (By similarity). {ECO:0000250}.
DE  Reference Proteome: Yes;
DE  Interaction: Q9EPX0; IntAct: EBI-12593062; Score: 0.27
DE  Interaction: Q5U2U8; IntAct: EBI-12593066; Score: 0.27
DE  Interaction: D4A4T0; IntAct: EBI-12593095; Score: 0.27
DE  Interaction: P63018; IntAct: EBI-12593099; Score: 0.27
GO  GO:0005737;
GO  GO:0005634;
GO  GO:0048471;
GO  GO:0030018;
GO  GO:0001671;
GO  GO:0051087;
GO  GO:0003677;
GO  GO:0031072;
GO  GO:0044183;
GO  GO:0051082;
GO  GO:0030036;
GO  GO:0061077;
GO  GO:0060710;
GO  GO:0060717;
GO  GO:0030198;
GO  GO:0045109;
GO  GO:0043154;
GO  GO:0045892;
GO  GO:0090084;
GO  GO:0006457;
GO  GO:0034504;
GO  GO:0032880;
GO  GO:0060715;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MVDYYEVLGVQRHASPEDIKKAYRKQALKWHPDKNPENKEEAERKFKQVAEAYEVLSDAKKRDIYDKYGKEGLNGGGGGG
SQ  GSHFDSPFEFGFTFRNPDDVFREFFGGRDPFSFDFFEDPFDDFFGNRRGPRGSRSRGAGSFFSAFSGFPSFGSGFPAFDT
SQ  GFTPFGSLGHGGLTSFSSASFGGSGMGNFKSISTSTKIVNGKKITTKRIVENGQERVEVEEDGQLKSLTINGVADENALA
SQ  EECRRRGQPTPALAPGPAPAPARVPSQARPPTPAPTPAPAQTPAPSVSTRPQKPPRPAPTAKLVSKSNWEDEEQDRQRVP
SQ  GNCDAPMTSAGLKEGGKRKKQKQKEDSKKKKSTKGNH
//