ID  Q6B9X6;
PN  Alpha-protein kinase vwkA;
GN  vwkA;
OS  44689;
SL  Nucleus Position: SL-0198;
SL  Comments: Cytoplasm, cytosol {ECO:0000269|PubMed:15728726}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:15728726}. Contractile vacuole membrane {ECO:0000269|PubMed:15728726}. Note=Enriched adjacent to large spherical structures such as contractile vacuoles and Golgi-like structures (perinuclear).
DR  UNIPROT: Q6B9X6;
DR  UNIPROT: Q55FF0;
DR  Pfam: PF02816;
DR  PROSITE: PS51158;
DE  Function: Displays a modest preference for threonine over serine residues. Does not phosphorylate myosin II, however can phosphorylate MBP, in vitro. May be involved in the regulation of myosin II function during cytokinesis. Overexpression leads to impaired cell proliferation in suspension culture and fails to develop beyond the mound stage. Both overexpression and absence of the gene can result in defects in cytokinesis and alterations in myosin II abundance and assembly. {ECO:0000269|PubMed:15728726, ECO:0000269|PubMed:18381083}.
DE  Reference Proteome: Yes;
GO  GO:0031164;
GO  GO:0000331;
GO  GO:0005737;
GO  GO:0005829;
GO  GO:0048471;
GO  GO:0005524;
GO  GO:0005516;
GO  GO:0004672;
GO  GO:0106310;
GO  GO:0004674;
GO  GO:0070177;
GO  GO:0033298;
GO  GO:0006971;
GO  GO:0000281;
GO  GO:0031038;
GO  GO:0018209;
GO  GO:0006468;
GO  GO:0031156;
GO  GO:0031288;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MESKYVLSTEKESKTKPSGRVNVSDMDSISNSLSKTSLGTRKVPTSLKTDASRSGLSSGGSKTHISDESALRMVYGSTPR
SQ  DEKTTTTKDSITLAKEKEKKIEKRNEEIKLTFKAIRASECVDLLFIVDCTGSMDPYIEQIKSDIVKLQEALKLKHSFLDI
SQ  EFGFIRYTDFDVASNRCSTFQFSRSTVEFVRFVSEIRAGGGADGPEDVFGGMDLIKSMKWRPNSTRVVIHIADAPCHGTE
SQ  YHSMADSYPGGDPNGIKLDDLLTDIISLNINYYFGHINLKETGQMIDFFDKKTKEISRNKKSINSFDSKETSKMNERIFI
SQ  SIEESISVSRSVLTEQYLGHNIDGSTGKQRSEREFEINTNMDIDFGELPYIQMLQTKFKMPSDIVTCLSSSYEMKLNEIT
SQ  ISIKIAPNPFSHGACRLAYLGIDEHGKKVVLKQSKYIGGRENSKKRYFESMECQTVAAKFALEFNKQLSLTSSEHQITFT
SQ  VAKVLQMKHSEKPMYFGIETFINGEYQKYNSNCGWLKDDAMSEILQTFSHWTYQESKNKAIVVDIQGVKTSKGYLLTDPA
SQ  IHSTDTLRFGSCNLGKPGIIKFFQSHKCNQHCKKLGLTIPSFTSSSSTSSSSRSTSSSSSISYSY
//