ID  Q6DFF6;
PN  Kelch-like protein 20;
GN  klhl20;
OS  8355;
SL  Nucleus Position: SL-0198;
SL  Comments: Cytoplasm, perinuclear region {ECO:0000250}. Nucleus {ECO:0000250}.
DR  UNIPROT: Q6DFF6;
DR  Pfam: PF07707;
DR  Pfam: PF00651;
DR  Pfam: PF01344;
DR  PROSITE: PS50097;
DE  Function: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. The BCR(KLHL20) E3 ubiquitin ligase complex mediates the ubiquitination of target proteins, leading to their degradation by the proteasome. It also specifically mediates 'Lys-33'-linked ubiquitination (By similarity). {ECO:0000250}.
DE  Reference Proteome: Yes;
GO  GO:0031463;
GO  GO:0005737;
GO  GO:0005829;
GO  GO:0048471;
GO  GO:0016605;
GO  GO:0005802;
GO  GO:0019964;
GO  GO:0004842;
GO  GO:0006895;
GO  GO:0043066;
GO  GO:0043161;
GO  GO:1990390;
GO  GO:0015031;
GO  GO:0016567;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MRRCLNTRPGETGMDVTSRCTLGDPNKLPEGVPQPARMPYVSDKHPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVI
SQ  LSACSPYFRAMFTGELAESRQTEVVIRDIDERAMELLIDFSYTSQITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQL
SQ  DPSNCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYSIQE
SQ  RRPQLPQVLQHVRLPLLSPKFLVGTVGSDPLIKSDEECRDLVDEAKNYLLLPQERPLMQGPRTRPRKPIRCGEVLFAVGG
SQ  WCSGDAISSVERYDPQTNEWRMVASMSKRRCGVGVSVLDDLLYAVGGHDGSSYLNSVERYDPKTNQWSSDVAPTSTCRTS
SQ  VGVAVLGGYLYAVGGQDGVSCLNIVERYDPKENKWTRVASMSTRRLGVAVAVLGGFLYAVGGSDGTSPLNTVERYNPQEN
SQ  RWHTIAPMGTRRKHLGCAVYQDMIYAVGGRDDTTELSSAERYNPRTNQWSPVVAMTSRRSGVGLAVVNGQLMAVGGFDGT
SQ  TYLKTIEVFDPDANTWRLYGGMNYRRLGGGVGVIKMTHCESHIW
//