ID  Q6DGE9;
PN  Protein unc-45 homolog B;
GN  unc45b;
OS  7955;
SL  Nucleus Position: SL-0198;
SL  Comments: Cytoplasm, myofibril, sarcomere, Z line {ECO:0000269|PubMed:18347070, ECO:0000269|PubMed:20440001}. Cytoplasm, myofibril, sarcomere, A band {ECO:0000269|PubMed:18347070, ECO:0000269|PubMed:20440001}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:18347070, ECO:0000269|PubMed:20440001}. Note=Expressed at the Z line and in the perinuclear region of myofibrils. Translocates to the A band in response to stress conditions and fibril damage. {ECO:0000269|PubMed:18347070, ECO:0000269|PubMed:20440001}.
DR  UNIPROT: Q6DGE9;
DR  UNIPROT: Q8UVX6;
DR  Pfam: PF11701;
DR  PROSITE: PS50293;
DE  Function: Acts as a co-chaperone for HSP90 and is required for proper folding of the myosin motor domain (By similarity). Plays a role in sarcomere formation during muscle cell development. Required for myoseptal integrity, myofiber attachment, motility and craniofacial development (PubMed:17189627, PubMed:17586488, PubMed:20440001, PubMed:20849610). Is necessary for normal early lens development (PubMed:24549050). {ECO:0000250|UniProtKB:Q8CGY6, ECO:0000269|PubMed:17189627, ECO:0000269|PubMed:17586488, ECO:0000269|PubMed:20440001, ECO:0000269|PubMed:20849610, ECO:0000269|PubMed:24549050}.
DE  Reference Proteome: Yes;
GO  GO:0031672;
GO  GO:0005737;
GO  GO:0048471;
GO  GO:0030018;
GO  GO:0051879;
GO  GO:0048738;
GO  GO:0061077;
GO  GO:0002088;
GO  GO:0030239;
GO  GO:0060538;
GO  GO:0007519;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MTMGEIGDSVQLKEEGNKHFQAGEIDQAIDCYTKAIKTCKKEDKKALAVIYRNRSACFLKKENYSNAASDATKAIDVDAA
SQ  DIKALYRRCQAFEKLGKLDMAFKDVQRCATIEPKNKTFLETLRRLGAEIQQKLKTTFSTDSRVQNMFDILFSDEPDKEKR
SQ  EKAANNLIVLAREDAGAERIFQNNGVPLLMQLIDTGKPEMILAAIRTLSGMCTGHRARATAIIHSVGISKLCSIMAVDNE
SQ  EIALATANLFQCVNDSLSGGDKRNYGKEEALVLDSSKDLKDILLALLEMIASKNVSGHGRDQALNLLTKNVPRQNKKSTD
SQ  NSKCLFTIDHGLKKILKVCGQVPDLPDQLPMTENTQLIASVLLSKLYDDLRCDPERDQFRDICDDYIKSKFDPNDMDKNI
SQ  HAINTLSGILQGPFDLGNVLAGRQGVMEMMVALCGSEREVDQLVAVEALIHASTKTSKASFFISNGVSLLKEMYKKTKNE
SQ  KIKIRALVGLCKLGSAGGDDYSMRQFAEGSTEKLAKQCRKWLCNPTLDVRTRKWAIEGLAYLTNDADVKDDFAEDEPAMR
SQ  AMFELTKSNDKTILYAVACTLVNCTNSYDKKEIIPEMVQLAKFSKQHVPEQHPKDKKDFIVRRVKRLLKAGVTSALAVMV
SQ  KADNSILTDQTKEMLARVFLALTEDVKDRGIIVAQGGGKALIPLALEGTDKGKIKASHALAKIAAVSNPEIAFPGERIYE
SQ  VVRPLVSLLGTDRDGMENFEALRGLTNLAGLNDKLRVKILKEKALPEIENYMFEDHEQIRQAATECMCNLVCCKEVQDRY
SQ  LEDGNDKLKLLVLLCGEDEEKLQRAAAGALAMLTAAQKKLAVKMTKVTEQWLEILQRLCIHDNPEIQHRGLVTVFNMLDA
SQ  DDQLAKKLVESDMLEILTYVAKLEDNPKKQNAIDAARACLSKAMDNGLIKPFSN
//