ID Q6DHN0; PN Transmembrane protein 53; GN tmem53; OS 7955; SL Nucleus Position: SL-0178; SL Nucleus Position: SL-0182; SL Nucleus Position: SL-0183; SL Comments: Nucleus outer membrane {ECO:0000250|UniProtKB:Q9D0Z3}; Single-pass membrane protein {ECO:0000305}. DR UNIPROT: Q6DHN0; DR Pfam: PF05705; DE Function: Ensures normal bone formation, through the negative regulation of bone morphogenetic protein (BMP) signaling in osteoblast lineage cells by blocking cytoplasm-nucleus translocation of phosphorylated SMAD proteins. {ECO:0000250|UniProtKB:Q9D0Z3}. DE Reference Proteome: Yes; GO GO:0016021; GO GO:0031965; GO GO:0005640; GO GO:0030514; GO GO:0030279; GO GO:0045668; GO GO:0046822; TP Membrane Topology: Transmembrane; Source: UniProt - Sequence Analysis {ECO:0000255}; SQ MGDDDLDYNIVFSEALISEKHWRGSKEPVVILLGWAGSRDKHLAKYSSIYNEQGCTTLRYTAPLKTVFISESLGYKELRS SQ TAHKLLELLYDYEVENNPIFFHVFSNGGFMLYRYMVELLHSHKQFSTLCVVGTVVDSAPGSQNVVGALRALKTTLGPKVN SQ VLLQYFLLALFAVAVFLLRIVLYPLTKYFHRNHYDAMMEHPAPWPQMYLYSRADRVIRYRDVEKMVKGLQEKGLMVESFD SQ FITPAHVSLFRDCPEDYSNRCRTFLSHCMTTSEEILMKKHH //