ID  Q6GLC9;
PN  Fragile X messenger ribonucleoprotein 1 homolog;
GN  fmr1;
OS  8364;
SL  Nucleus Position: SL-0198;
SL  Comments: Nucleus {ECO:0000250|UniProtKB:Q06787}. Nucleus, nucleolus {ECO:0000250|UniProtKB:Q06787}. Chromosome, centromere {ECO:0000250|UniProtKB:P35922}. Chromosome {ECO:0000250|UniProtKB:P35922}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q06787}. Cytoplasm, Cytoplasmic ribonucleoprotein granule {ECO:0000250|UniProtKB:Q06787}. Perikaryon {ECO:0000250|UniProtKB:Q06787}. Cell projection, neuron projection {ECO:0000250|UniProtKB:Q06787}. Cell projection, axon {ECO:0000250|UniProtKB:P35922}. Cell projection, dendrite {ECO:0000250|UniProtKB:P35922}. Cell projection, dendritic spine {ECO:0000250|UniProtKB:P35922}. Synapse, synaptosome {ECO:0000250|UniProtKB:P35922}. Cell projection, growth cone {ECO:0000250|UniProtKB:Q06787}. Cell projection, filopodium tip {ECO:0000250|UniProtKB:P35922}. Synapse {ECO:0000250|UniProtKB:P35922}. Postsynaptic cell membrane {ECO:0000250|UniProtKB:P35922}. Presynaptic cell membrane {ECO:0000250|UniProtKB:P35922}. Cell membrane {ECO:0000250|UniProtKB:P35922}. Cytoplasm, Stress granule {ECO:0000250|UniProtKB:Q06787}.
DR  UNIPROT: Q6GLC9;
DR  Pfam: PF05641;
DR  Pfam: PF16098;
DR  Pfam: PF12235;
DR  Pfam: PF00013;
DR  Pfam: PF17904;
DR  Pfam: PF18336;
DR  PROSITE: PS51641;
DR  PROSITE: PS50084;
DE  Function: Multifunctional polyribosome-associated RNA-binding protein that plays a central role in neuronal development and synaptic plasticity through the regulation of alternative mRNA splicing, mRNA stability, mRNA dendritic transport and postsynaptic local protein synthesis of a subset of mRNAs. Binds poly(G) and poly(U), and to a lower extent poly(A) and poly(C). {ECO:0000250|UniProtKB:P35922, ECO:0000250|UniProtKB:P51113, ECO:0000250|UniProtKB:Q06787, ECO:0000250|UniProtKB:Q80WE1}.
DE  Reference Proteome: Yes;
GO  GO:0070161;
GO  GO:0030424;
GO  GO:0043679;
GO  GO:0042995;
GO  GO:0010369;
GO  GO:0005694;
GO  GO:0000775;
GO  GO:0005737;
GO  GO:0036464;
GO  GO:0010494;
GO  GO:0030425;
GO  GO:1902737;
GO  GO:0043197;
GO  GO:0044326;
GO  GO:0019897;
GO  GO:0032433;
GO  GO:0097386;
GO  GO:0030426;
GO  GO:1990812;
GO  GO:0016020;
GO  GO:0043005;
GO  GO:0043025;
GO  GO:0071598;
GO  GO:0005730;
GO  GO:0005654;
GO  GO:0005634;
GO  GO:0043204;
GO  GO:0048471;
GO  GO:0005844;
GO  GO:0098794;
GO  GO:0014069;
GO  GO:0045211;
GO  GO:0098793;
GO  GO:0042734;
GO  GO:1990904;
GO  GO:0045202;
GO  GO:0003682;
GO  GO:0070840;
GO  GO:0002151;
GO  GO:0035064;
GO  GO:0008017;
GO  GO:0035198;
GO  GO:0003730;
GO  GO:0048027;
GO  GO:0003729;
GO  GO:0034046;
GO  GO:0008266;
GO  GO:0046982;
GO  GO:0042803;
GO  GO:0003723;
GO  GO:0035613;
GO  GO:0033592;
GO  GO:1990825;
GO  GO:0035197;
GO  GO:0045182;
GO  GO:0030371;
GO  GO:0007420;
GO  GO:0048755;
GO  GO:0051216;
GO  GO:0050890;
GO  GO:0006281;
GO  GO:0021905;
GO  GO:0007215;
GO  GO:0006397;
GO  GO:0051028;
GO  GO:2000766;
GO  GO:0010629;
GO  GO:1900453;
GO  GO:2000301;
GO  GO:0017148;
GO  GO:0045947;
GO  GO:1901386;
GO  GO:0014036;
GO  GO:0048812;
GO  GO:0060999;
GO  GO:0051491;
GO  GO:2000637;
GO  GO:1902416;
GO  GO:1901800;
GO  GO:0001934;
GO  GO:0002092;
GO  GO:2001022;
GO  GO:0045727;
GO  GO:0000381;
GO  GO:0060998;
GO  GO:0051489;
GO  GO:0060964;
GO  GO:0090365;
GO  GO:0043488;
GO  GO:0098908;
GO  GO:0046928;
GO  GO:0008380;
GO  GO:0060538;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MEELAVEVRGSNGAFYKAFVKDVHEDSITVTFENNWQQERQIPFHDVRFPPPSGYNKDINESDEVEVYSRANEKEPCCWW
SQ  LAKVRMIKGEFYVIEYAACDATYNEIVTIERLRSVNPNKPATKNSFHKVKLDVPEDLRQMCAKDSAHKDFKKAVGAFSVS
SQ  YDSENYQLVILSVNEVTIKRANMLSDMHFRSLRTKLSLMLRNEEASKQLESSRQLASRFHEQFIVREDLMGLAIGTHGAN
SQ  IQQARKVPGVTAIDLDEDTCTFHIYGEDQEAVKKARTYLEFAEDVIQVPRNLVGKVIGKNGKLIQEIVDKSGVVRVRIEA
SQ  ENDKNISPEEGMVPFVFVGTKDSITNATVLLDYHLNYLKEVDQLRLERLQIDEQLRQIGASSRPPPNRPDKEKGYQSEDL
SQ  SGTGRGSRPYNNRGRSRRGTGYASDIRYGDPDYRKTTYPEYPRSQAFWIKGTNSEASNASETESDHRDELSDWSLAPAED
SQ  DRDNYHRRGDGRRRGGPRGQGMRGRGGFKGNDDQPRPDNRQRNSRETKARTSDGSLQIRIDCNNERSVHTKTLQNASVEG
SQ  SRLRTGKDRVQKKEKSEVVDGPQVVVNGIP
//