ID  Q6IBS0;
PN  Twinfilin-2;
GN  TWF2;
OS  9606;
SL  Nucleus Position: SL-0198;
SL  Comments: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:10406962}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:10406962}. Cell projection, stereocilium {ECO:0000250}. Note=Perinuclear and G-actin-rich cortical actin structure sublocalization.
DR  UNIPROT: Q6IBS0;
DR  UNIPROT: Q9Y3F5;
DR  PDB: 2VAC;
DR  PDB: 2W0I;
DR  Pfam: PF00241;
DR  PROSITE: PS51263;
DR  OMIM: 607433;
DR  DisGeNET: 11344;
DE  Function: Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G- actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles. May play a role in regulating the mature length of the middle and short rows of stereocilia (By similarity). {ECO:0000250}.
DE  Reference Proteome: Yes;
DE  Interaction: P05060; IntAct: EBI-735501; Score: 0.00
DE  Interaction: Q9NSB4; IntAct: EBI-1061916; Score: 0.00
DE  Interaction: P78386; IntAct: EBI-1062282; Score: 0.00
DE  Interaction: Q9NX58; IntAct: EBI-1062871; Score: 0.00
DE  Interaction: P47755; IntAct: EBI-1063407; Score: 0.00
DE  Interaction: Q15323; IntAct: EBI-1063559; Score: 0.00
DE  Interaction: Q8IV63; IntAct: EBI-1064108; Score: 0.00
DE  Interaction: Q8IUD2; IntAct: EBI-1067184; Score: 0.00
DE  Interaction: P52907; IntAct: EBI-1070516; Score: 0.00
DE  Interaction: O76013; IntAct: EBI-1070997; Score: 0.00
DE  Interaction: Q504Q3; IntAct: EBI-1072020; Score: 0.00
DE  Interaction: Q9BW60; IntAct: EBI-1072650; Score: 0.00
DE  Interaction: P47756; IntAct: EBI-1073048; Score: 0.00
DE  Interaction: Q9P1U1; IntAct: EBI-1080652; Score: 0.00
DE  Interaction: Q81X78; IntAct: EBI-2819826; Score: 0.00
DE  Interaction: Q92949; IntAct: EBI-3916056; Score: 0.37
DE  Interaction: Q13418; IntAct: EBI-3916066; Score: 0.37
DE  Interaction: Q15051; IntAct: EBI-4286917; Score: 0.35
DE  Interaction: P52565; IntAct: EBI-7410932; Score: 0.37
DE  Interaction: O00159; IntAct: EBI-11030803; Score: 0.35
DE  Interaction: P60710; IntAct: EBI-11045267; Score: 0.35
DE  Interaction: Q9UHB6; IntAct: EBI-11058729; Score: 0.35
DE  Interaction: Q9WUM4; IntAct: EBI-11065690; Score: 0.35
DE  Interaction: Q8N3V7; IntAct: EBI-11086992; Score: 0.35
DE  Interaction: P35579; IntAct: EBI-11098811; Score: 0.35
DE  Interaction: Q9NYB0; IntAct: EBI-11306750; Score: 0.51
DE  Interaction: Q9NUX5; IntAct: EBI-11306760; Score: 0.37
DE  Interaction: Q6IQ23; IntAct: EBI-16398399; Score: 0.35
DE  Interaction: Q4VC05; IntAct: EBI-21637103; Score: 0.35
DE  Interaction: Q8WUZ0; IntAct: EBI-21637520; Score: 0.35
DE  Interaction: Q9NYL9; IntAct: EBI-21701240; Score: 0.35
DE  Interaction: Q562R1; IntAct: EBI-21867017; Score: 0.35
DE  Interaction: Q01518; IntAct: EBI-21867017; Score: 0.35
DE  Interaction: P68032; IntAct: EBI-21867017; Score: 0.35
DE  Interaction: P62736; IntAct: EBI-21867017; Score: 0.35
DE  Interaction: P60709; IntAct: EBI-21867017; Score: 0.35
DE  Interaction: P40123; IntAct: EBI-21867017; Score: 0.35
DE  Interaction: P05204; IntAct: EBI-20901080; Score: 0.40
DE  Interaction: Q5S007; IntAct: EBI-21360986; Score: 0.35
DE  Interaction: P04156; IntAct: EBI-21014654; Score: 0.35
DE  Interaction: Q14108; IntAct: EBI-21264396; Score: 0.35
DE  Interaction: P17813; IntAct: EBI-22197897; Score: 0.35
DE  Interaction: O75368; IntAct: EBI-25373235; Score: 0.35
DE  Interaction: F1PAA9; IntAct: EBI-27079701; Score: 0.27
DE  Interaction: Q8N488; IntAct: EBI-27111302; Score: 0.35
DE  Interaction: Q8N612; IntAct: EBI-34574737; Score: 0.27
GO  GO:0005884;
GO  GO:0005737;
GO  GO:0070062;
GO  GO:0030175;
GO  GO:0030426;
GO  GO:0030027;
GO  GO:0030016;
GO  GO:0048471;
GO  GO:0032420;
GO  GO:0051015;
GO  GO:0003785;
GO  GO:0005524;
GO  GO:0045296;
GO  GO:0005546;
GO  GO:0005080;
GO  GO:0003723;
GO  GO:0030042;
GO  GO:0051016;
GO  GO:0030030;
GO  GO:0071363;
GO  GO:0071300;
GO  GO:0030837;
GO  GO:0045773;
GO  GO:0010592;
GO  GO:0010976;
GO  GO:0032956;
GO  GO:0010591;
GO  GO:0032532;
GO  GO:0042989;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MAHQTGIHATEELKEFFAKARAGSVRLIKVVIEDEQLVLGASQEPVGRWDQDYDRAVLPLLDAQQPCYLLYRLDSQNAQG
SQ  FEWLFLAWSPDNSPVRLKMLYAATRATVKKEFGGGHIKDELFGTVKDDLSFAGYQKHLSSCAAPAPLTSAERELQQIRIN
SQ  EVKTEISVESKHQTLQGLAFPLQPEAQRALQQLKQKMVNYIQMKLDLERETIELVHTEPTDVAQLPSRVPRDAARYHFFL
SQ  YKHTHEGDPLESVVFIYSMPGYKCSIKERMLYSSCKSRLLDSVEQDFHLEIAKKIEIGDGAELTAEFLYDEVHPKQHAFK
SQ  QAFAKPKGPGGKRGHKRLIRGPGENGDDS
//