ID  Q6NRD3;
PN  E3 ubiquitin-protein ligase SH3RF1;
GN  sh3rf1;
OS  8355;
SL  Nucleus Position: SL-0198;
SL  Comments: Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q71F54}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:Q69ZI1}. Golgi apparatus, trans-Golgi network {ECO:0000250|UniProtKB:Q69ZI1}.
DR  UNIPROT: Q6NRD3;
DR  UNIPROT: Q3L1I1;
DR  Pfam: PF00018;
DR  Pfam: PF14604;
DR  Pfam: PF00097;
DR  PROSITE: PS50002;
DR  PROSITE: PS00518;
DR  PROSITE: PS50089;
DE  Function: Has E3 ubiquitin-protein ligase activity. In the absence of an external substrate, it can catalyze self-ubiquitination. Acts as a scaffold protein that contributes to the effective activation of the JNK signaling pathway (By similarity). Plays an essential role in the anterior neural development. {ECO:0000250|UniProtKB:Q69ZI1, ECO:0000250|UniProtKB:Q7Z6J0, ECO:0000269|PubMed:16125690}.
DE  Reference Proteome: Yes;
DE  Interaction: Q8QHK8; IntAct: EBI-7734026; Score: 0.40
DE  Interaction: O14964; IntAct: EBI-7734085; Score: 0.40
GO  GO:0005794;
GO  GO:0030027;
GO  GO:0048471;
GO  GO:0005078;
GO  GO:0046872;
GO  GO:0061630;
GO  GO:0001764;
GO  GO:0046330;
GO  GO:0051865;
GO  GO:0043370;
GO  GO:2000564;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MDESALLDLLECPVCLERLDASAKVLPCQHTFCKRCLLGIVSSRKELRCPECRTLVECGVDELPSNILLVRLLDGIRQRP
SQ  RKAGDGGSAGNSTNALRAQGSVTTNGGLNDAQNTQSGQQRIQARSPPVRGVPQLPCAKALYNYEGKEPGDLKFNKGDIIV
SQ  LRRQVDENWYHGEINGIHGFFPTNFVQIIKPLPQPPPQCKALYDFEVKDKEADKDCLPFLKDDILTVIRRVDENWAEGML
SQ  GDKIGIFPISYVEFNSAAKQLIELDKPSGADTGEGSSGTSHSGNSQKQADAKKNTKKRHSFTSLTMSNKSSQSVQNRHSM
SQ  EISPPVLISSSNPTAAARISELTGLSCSAPSQDMNPPLLPPPPMATPVITSASSGAAAVAQRNIIGPVEQVPHLRTSARP
SQ  SVFIAIYPYIPRKEDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYVAPVTRALTTATPAKVAMATATTSNVV
SQ  NLVTPTPPGAPCQKLPVSGVEFAKTSSTNGVSPAGVPGCHIQTSPQSKVLLHMSGQMTVNQARNAVRTAAAHSQDRPTAA
SQ  VTPIQAQTPAASALPQQAAASQQVPPPLSAPAAYINAAMNISRPSVPAASAASSALPTAAFEAESSWKSSSGLSGCSFSE
SQ  NVSAPLNSAANKQDKDSKKEKKGLLKLLSGASTKRKPRSSPPHSPTQEVEQTNSEAAAALEGAVGPDIVPVIVNGRAAPC
SQ  TVDCDSVSASTPAQDNRKPASLDNNIPIAPPPRQPCSSLGSVLNDSRPCERYRVMVSYPPQSEAELELKEGDIVFVHKKR
SQ  EDGWFKGTLQRNGKTGLFPGSFVENI
//