ID  Q6P9B9;
PN  Integrator complex subunit 5;
GN  INTS5;
OS  9606;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0182;
SL  Comments: Nucleus membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}. Nucleus {ECO:0000269|PubMed:23904267}. Cytoplasm {ECO:0000269|PubMed:23904267}.
DR  UNIPROT: Q6P9B9;
DR  UNIPROT: Q8N6W5;
DR  UNIPROT: Q9C0G5;
DR  PDB: 7CUN;
DR  PDB: 7PKS;
DR  Pfam: PF14838;
DR  Pfam: PF14837;
DR  OMIM: 611349;
DR  DisGeNET: 80789;
DE  Function: Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (PubMed:23904267). {ECO:0000269|PubMed:23904267, ECO:0000305|PubMed:16239144}.
DE  Reference Proteome: Yes;
DE  Interaction: P0DTC7; IntAct: EBI-25687011; Score: 0.35
DE  Interaction: P10909; IntAct: EBI-21693789; Score: 0.35
DE  Interaction: O00716; IntAct: EBI-7600105; Score: 0.35
DE  Interaction: Q76MZ3; IntAct: EBI-10991736; Score: 0.35
DE  Interaction: A5YKK6; IntAct: EBI-11005861; Score: 0.35
DE  Interaction: P80315; IntAct: EBI-11016531; Score: 0.35
DE  Interaction: Q8IX90; IntAct: EBI-11028949; Score: 0.35
DE  Interaction: P67775; IntAct: EBI-11058007; Score: 0.53
DE  Interaction: Q8BH65; IntAct: EBI-11109889; Score: 0.35
DE  Interaction: Q9D1D4; IntAct: EBI-11111397; Score: 0.35
DE  Interaction: Q9CY25; IntAct: EBI-11113050; Score: 0.35
DE  Interaction: Q9D8B3; IntAct: EBI-11113387; Score: 0.35
DE  Interaction: E9Q512; IntAct: EBI-11157436; Score: 0.35
DE  Interaction: Q96SY0; IntAct: EBI-11160850; Score: 0.35
DE  Interaction: P60410; IntAct: EBI-24441770; Score: 0.56
DE  Interaction: P30153; IntAct: EBI-14025056; Score: 0.42
DE  Interaction: P32970; IntAct: EBI-21512742; Score: 0.35
DE  Interaction: Q9UN75; IntAct: EBI-21537575; Score: 0.35
DE  Interaction: O43493; IntAct: EBI-21537775; Score: 0.35
DE  Interaction: P35613; IntAct: EBI-21560440; Score: 0.35
DE  Interaction: Q9UQV4; IntAct: EBI-21563011; Score: 0.35
DE  Interaction: P49146; IntAct: EBI-21569349; Score: 0.35
DE  Interaction: Q8WWB7; IntAct: EBI-21569743; Score: 0.35
DE  Interaction: P01889; IntAct: EBI-21611619; Score: 0.35
DE  Interaction: P40259; IntAct: EBI-21668943; Score: 0.35
DE  Interaction: P01375; IntAct: EBI-21702931; Score: 0.35
DE  Interaction: P08173; IntAct: EBI-21707586; Score: 0.35
DE  Interaction: Q8WVE6; IntAct: EBI-21754350; Score: 0.35
DE  Interaction: Q9NS69; IntAct: EBI-21755768; Score: 0.35
DE  Interaction: P46013; IntAct: EBI-20562326; Score: 0.35
DE  Interaction: P03372; IntAct: EBI-21301141; Score: 0.35
DE  Interaction: Q75QN2; IntAct: EBI-26617208; Score: 0.61
GO  GO:0005737;
GO  GO:0005829;
GO  GO:0016021;
GO  GO:0032039;
GO  GO:0016020;
GO  GO:0031965;
GO  GO:0005654;
GO  GO:0005634;
GO  GO:0034243;
GO  GO:0034472;
GO  GO:0016180;
TP  Membrane Topology: Transmembrane; Source: UniProt - Sequence Analysis {ECO:0000255};
SQ  MSALCDPPGAPGPPGPAPATHGPAPLSAQELSQEIKAFLTGVDPILGHQLSAREHARCGLLLLRSLPPARAAVLDHLRGV
SQ  FDESVRAHLAALDETPVAGPPHLRPPPPSHVPAGGPGLEDVVQEVQQVLSEFIRANPKAWAPVISAWSIDLMGQLSSTYS
SQ  GQHQRVPHATGALNELLQLWMGCRATRTLMDIYVQCLSALIGSCPDACVDALLDTSVQHSPHFDWVVAHIGSSFPGTIIS
SQ  RVLSCGLKDFCVHGGAGGGAGSSGGSSSQTPSTDPFPGSPAIPAEKRVPKIASVVGILGHLASRHGDSIRRELLRMFHDS
SQ  LAGGSGGRSGDPSLQATVPFLLQLAVMSPALLGTVSGELVDCLKPPAVLSQLQQHLQGFPREELDNMLNLAVHLVSQASG
SQ  AGAYRLLQFLVDTAMPASVITTQGLAVPDTVREACDRLIQLLLLHLQKLVHHRGGSPGEGVLGPPPPPRLVPFLDALKNH
SQ  VGELCGETLRLERKRFLWQHQLLGLLSVYTRPSCGPEALGHLLSRARSPEELSLATQLYAGLVVSLSGLLPLAFRSCLAR
SQ  VHAGTLQPPFTARFLRNLALLVGWEQQGGEGPAALGAHFGESASAHLSDLAPLLLHPEEEVAEAAASLLAICPFPSEALS
SQ  PSQLLGLVRAGVHRFFASLRLHGPPGVASACQLLTRLSQTSPAGLKAVLQLLVEGALHRGNTELFGGQVDGDNETLSVVS
SQ  ASLASASLLDTNRRHTAAVPGPGGIWSVFHAGVIGRGLKPPKFVQSRNQQEVIYNTQSLLSLLVHCCSAPGGTECGECWG
SQ  APILSPEAAKAVAVTLVESVCPDAAGAELAWPPEEHARATVERDLRIGRRFREQPLLFELLKLVAAAPPALCYCSVLLRG
SQ  LLAALLGHWEASRHPDTTHSPWHLEASCTLVAVMAEGSLLPPALGNMHEVFSQLAPFEVRLLLLSVWGFLREHGPLPQKF
SQ  IFQSERGRFIRDFSREGGGEGGPHLAVLHSVLHRNIDRLGLFSGRFQAPSPSTLLRQGT
//