ID  Q6PB66;
PN  Leucine-rich PPR motif-containing protein, mitochondrial;
GN  Lrpprc;
OS  10090;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0179;
SL  Nucleus Position: SL-0182;
SL  Nucleus Position: SL-0183;
SL  Comments: Mitochondrion {ECO:0000250}. Nucleus {ECO:0000269|PubMed:12071956}. Nucleus, nucleoplasm {ECO:0000250}. Nucleus inner membrane {ECO:0000250}. Nucleus outer membrane {ECO:0000250}.
DR  UNIPROT: Q6PB66;
DR  UNIPROT: Q8K4V0;
DR  UNIPROT: Q9CRX4;
DR  Pfam: PF01535;
DR  Pfam: PF17177;
DR  PROSITE: PS51375;
DE  Function: May play a role in RNA metabolism in both nuclei and mitochondria. In the nucleus binds to HNRPA1-associated poly(A) mRNAs and is part of nmRNP complexes at late stages of mRNA maturation which are possibly associated with nuclear mRNA export. May bind mature mRNA in the nucleus outer membrane. In mitochondria binds to poly(A) mRNA. Plays a role in translation or stability of mitochondrially encoded cytochrome c oxidase (COX) subunits. May be involved in transcription regulation. Cooperates with PPARGC1A to regulate certain mitochondrially encoded genes and gluconeogenic genes and may regulate docking of PPARGC1A to transcription factors. Seems to be involved in the transcription regulation of the multidrug-related genes MDR1 and MVP. Part of a nuclear factor that binds to the invMED1 element of MDR1 and MVP gene promoters (By similarity). Binds single-stranded DNA. {ECO:0000250}.
DE  Reference Proteome: Yes;
DE  Interaction: O70343; IntAct: EBI-1371242; Score: 0.44
DE  Interaction: Q8VHJ7; IntAct: EBI-1371302; Score: 0.40
DE  Interaction: Q9R1E0; IntAct: EBI-1371337; Score: 0.52
DE  Interaction: P68510; IntAct: EBI-8586548; Score: 0.35
DE  Interaction: O54957; IntAct: EBI-12602258; Score: 0.35
DE  Interaction: Q62108; IntAct: EBI-16724752; Score: 0.35
DE  Interaction: P51637; IntAct: EBI-20565496; Score: 0.35
DE  Interaction: A2AKD7; IntAct: EBI-20566393; Score: 0.35
DE  Interaction: Q9NRI5; IntAct: EBI-26612017; Score: 0.35
GO  GO:0000794;
GO  GO:0005737;
GO  GO:0005856;
GO  GO:0005874;
GO  GO:0042645;
GO  GO:0005739;
GO  GO:0005637;
GO  GO:0005640;
GO  GO:0005654;
GO  GO:0005634;
GO  GO:0048471;
GO  GO:1990904;
GO  GO:0048487;
GO  GO:0003730;
GO  GO:0003723;
GO  GO:0003697;
GO  GO:0031625;
GO  GO:0000957;
GO  GO:0051028;
GO  GO:0000961;
GO  GO:0070129;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MAALLRPARWLLGAAAAPRLPLSLRLPAGVPGRLSSVVRVAAVGSRPAAGERLSQARLYAIVAEKRDLQEEPAPVRKNSS
SQ  QFDWALMRLDNSVRRTGRITKGLLQRVFESTCSSGSPGSNQALLLLRSCGSLLPELSLAERTEFAHKIWDKLQQLGVVYD
SQ  VSHYNALLKVYLQNEYKFSPTDFLAKMEGANIQPNRVTYQRLIAAYCNVGDIEGASKILGFMKTKDLPITEAVFSALVTG
SQ  HARAGDMENAENILTVMKQAGIEPGPDTYLALLNAHAERGDIGQVRQILEKVEKSDHYFMDRDFLQVIFSFSKAGYPQYV
SQ  SEILEKITYERRSIPDAMNLILFLATEKLEDTAFQVLLALPLSKDESSDNFGSFFLRHCVTLDLPPEKLIDYCRRLRDAK
SQ  LHSSSLQFTLHCALQANRTALAKAVMEALREEGFPIRPHYFWPLLAGHQKTKNVQGIIDILKIMNKVGVDPDQETYINYV
SQ  FPCFDSAQSVRAALQENECLLASSTFAQAEVKNEAINGNLQNILSFLESNTLPFSFSSLRNSLILGFRRSMNIDLWSKIT
SQ  ELLYKDERYCSKPPGPAEAVGYFLYNLIDSMSDSEVQAKEERLRQYFHQLQEMNVKVPENIYKGICNLLNTYHVPELIKD
SQ  IKVLVDREKVDSQKTSQVTSSDLESTLEKLKAEGQPVGSALKQLLLLLCSEENMQKALEVKAKYESDMVIGGYAALINLC
SQ  CRHDNAEDAWNLKQEVDRLDASAILDTAKYVALVKVLGKHSRLQDAINILKEMKEKDVVIKDATVLSFFHILNGAALRGE
SQ  IETVKQLHEAIVTLGLAKPSSNISFPLVTVHLEKGDLPAALEASIACHKKYKVLPRIHDVLCKLVEKGETDLIQKAMDFV
SQ  SQEQGEMTMLYDLFFAFLQTGNYKEAKKIIETPGIRARPTRLQWFCDRCIASNQVEALEKLVELTEKLFECDRDQMYYNL
SQ  LKLYKISSDWQRADAAWTKMQEENIIPRERTLRLLAEILKTSNQEVPFDVPELWFGDDRPSLSPSSRSAGEDVTEKTLLS
SQ  NCKLKKSKDAYNIFLKAEKQNVVFSSETYSTLIGLLLSKDDFTQAMHVKDFAETHIKGFTLNDAANSLLIIRQVRRDYLK
SQ  GALATLRAALDLKQVPSQIAVTRLIQALALKGDVESIEAIQRMVAGLDTIGLSKMVFINNIALAQMKNNKLDAAIENIEH
SQ  LLASENQAIEPQYFGLSYLFRKVIEEQMEPALEKLSIMSERMANQFALYKPVTDLFLQLVDSGKVDEARALLERCGAIAE
SQ  QSSLLSVFCLRTSQKPKKAPVLKTLLELIPELRDNDKVYSCSMKSYALDKDVASAKALYEYLTAKNLKLDDLFLKRYAAL
SQ  LKDVGEPVPFPEPPESFAFYIKQLKEARESPS
//