ID  Q6PFP6;
PN  NADPH-dependent diflavin oxidoreductase 1;
GN  ndor1;
OS  7955;
SL  Nucleus Position: SL-0198;
SL  Comments: Cytoplasm, perinuclear region {ECO:0000255|HAMAP- Rule:MF_03178}. Note=Concentrated in perinuclear structure. {ECO:0000255|HAMAP-Rule:MF_03178}.
DR  UNIPROT: Q6PFP6;
DR  UNIPROT: Q5RL12;
DR  Pfam: PF00667;
DR  Pfam: PF00258;
DR  Pfam: PF00175;
DR  PROSITE: PS51384;
DR  PROSITE: PS50902;
DE  Function: NADPH-dependent reductase which is a central component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Transfers electrons from NADPH via its FAD and FMN prosthetic groups to the [2Fe-2S] cluster of ciapin1, another key component of the CIA machinery. In turn, this reduced cluster provides electrons for assembly of cytosolic iron-sulfur cluster proteins. It can also reduce the [2Fe-2S] cluster of cisd1 and activate this protein implicated in Fe/S cluster repair. {ECO:0000255|HAMAP-Rule:MF_03178}.
DE  Reference Proteome: Yes;
GO  GO:0005829;
GO  GO:0048471;
GO  GO:0009055;
GO  GO:0050660;
GO  GO:0010181;
GO  GO:0050661;
GO  GO:0003958;
GO  GO:0016491;
GO  GO:0016731;
GO  GO:0016653;
GO  GO:0008219;
GO  GO:0036245;
GO  GO:0016226;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MSGHTVLVLYGSQTGTAQDTAERIGRQAQRRRLRVKVEALDTYNVVNLISESLVVFVCATTGQGDPPDNMKKFWRFLFRK
SQ  SLPADSLSRLDCAVLGLGDSSYPKFNFVAKKLHKRLLQLGANMLLPVGLADDQHDLGPDGVIDPWLLSFWQKTLSLYPPP
SQ  AGLAPLREEDKLPPRYIFHFLSEVPNKLTEHLQTVDNKSSPTPLRPFPAPLVFNQRVTHTAHFQDVRHIEFDITGSNIEF
SQ  SAGDTVMMRPCNTSEDVEQLCQLLKLDPESYFTLTPTDSSTEVPARLPQPCSIRFLLEHFLDISAVPRRSFFELLATFAT
SQ  DELEQEKLLEFSSAAGQDTLHSYCNRPRRTALEVLTDFPHTTAELSIGRLLDLFPEIQPRSFSIASSLLEHPNRIQILLA
SQ  VVKYKTMLVKPRKGLCSSWLASLDPSKGDVYVPLWVKKGSLKFPQDPESPVIMVGPGTGVAPFRSAIQERVAQGKMANVL
SQ  FFGCRSESKDFYCGSEWQEKVQAGQMILVTAFSRDQEDKVYVQHRVKEQGKLLWDLIAKKNAFFYIAGNAKQMPTSVCDA
SQ  LKAVFQKEGGMSENQAQEMLDGMEKNGRFQSETWS
//