ID  Q6PGF7;
PN  Exocyst complex component 8;
GN  Exoc8;
OS  10090;
SL  Nucleus Position: SL-0198;
SL  Comments: Cytoplasm {ECO:0000250|UniProtKB:O54924}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:O54924}. Cell projection, growth cone {ECO:0000250|UniProtKB:O54924}. Cell projection {ECO:0000250|UniProtKB:O54924}. Note=Binds lipids with phosphatidylinositol 3,4,5-trisphosphate groups (By similarity). Perinuclear in undifferentiated PC12 cells. Redistributes to growing neurites and growth cones during NGF-induced neuronal differentiation (By similarity). Localizes at the leading edge of migrating cells (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:O54924}.
DR  UNIPROT: Q6PGF7;
DR  Pfam: PF16528;
DR  PROSITE: PS50003;
DE  Function: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. {ECO:0000250}.
DE  Reference Proteome: Yes;
DE  Interaction: Q91VJ1; IntAct: EBI-6253412; Score: 0.27
DE  Interaction: Q9EPB4; IntAct: EBI-6253421; Score: 0.27
GO  GO:0031252;
GO  GO:0000145;
GO  GO:0030426;
GO  GO:0005770;
GO  GO:0048471;
GO  GO:0005886;
GO  GO:0035091;
GO  GO:0031267;
GO  GO:0007032;
GO  GO:0006887;
GO  GO:0022617;
GO  GO:0006893;
GO  GO:0090148;
GO  GO:0000281;
GO  GO:0008104;
GO  GO:0015031;
GO  GO:0006904;
GO  GO:0090522;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MSDSGASRLRRQLESGGFEARLYVKQLSQQSDGDRDLQEHRQRVQALAEETAQNLKRNVYQNYRQFIETAREISYLESEM
SQ  YQLSHLLTEQKSSLESIPLALLPAAAAGASAGEDTAGAGPRERGAVQAGFLPGPAGVPREGSGTGEEGKQRTLTTLLEKV
SQ  EGCRDLLETPGQYLVYNGDLVEYDADHMAQLQRVHGFLMNDCLLVATWLPQRRGMYRYNALYPLDRLAVVNVKDNPPMKD
SQ  MFKLLMFPESRIFQAENAKIKREWLEVLEETKRALSDKRRREQEEAAAPRAPPPVTSKGSNPFEDEDDEELATPEAEEEK
SQ  VDLSMEWIQELPEDLDVCIAQRDFEGAVDLLDKLNHYLEDKPSPPPVKELRAKVDERVRQLTEVLVFELSPDRSLRGGPK
SQ  ATRRAVSQLIRLGQCTKACELFLRNRAAAVHTAIRQLRIEGATLLYIHKLCHVFFTSLLETAREFETDFAGTDSGCYSAF
SQ  VVWARSAMGMFVDAFSKQVFDSKESLSTAAECVKVAKEHCQQLGEIGLDLTFIIHALLVKDIQGALHSYKEIIIEATKHR
SQ  NSEEMWRRMNLMTPEALGKLKEEMKSCGVSNFEQYTGDDCWVNLSYTVVAFTKQTMGFLEEALKLYFPELHMVLLESLVE
SQ  IILVAVQHVDYSLRCEQDPEKKAFIRQNASFLYETVLPVVERRFEEGVGKPAKQLQDLRNASRLLRVNPESTTSVV
//