ID  Q6PIW4;
PN  Fidgetin-like protein 1;
GN  FIGNL1;
OS  9606;
SL  Nucleus Position: SL-0198;
SL  Comments: Nucleus {ECO:0000269|PubMed:23754376}. Cytoplasm {ECO:0000250|UniProtKB:Q8BPY9}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q8BPY9}. Note=Together with RAD51 and a subset of H2A histone proteins, redistributed in discrete nuclear DNA damage- induced foci after ionizing radiation (IR) treatment (PubMed:23754376).
DR  UNIPROT: Q6PIW4;
DR  UNIPROT: D3DVM6;
DR  UNIPROT: Q86V18;
DR  UNIPROT: Q8ND59;
DR  UNIPROT: Q9H8P1;
DR  UNIPROT: Q9H917;
DR  PDB: 3D8B;
DR  Pfam: PF00004;
DR  Pfam: PF09336;
DR  PROSITE: PS00674;
DR  OMIM: 615383;
DR  DisGeNET: 63979;
DE  Function: Involved in DNA double-strand break (DBS) repair via homologous recombination (HR). Recruited at DSB sites independently of BRCA2, RAD51 and RAD51 paralogs in a H2AX-dependent manner. May regulate osteoblast proliferation and differentiation (PubMed:23754376). May play a role in the control of male meiosis dynamic (By similarity). {ECO:0000250|UniProtKB:Q8BPY9, ECO:0000269|PubMed:23754376}.
DE  Reference Proteome: Yes;
DE  Interaction: Q06609; IntAct: EBI-21840775; Score: 0.35
DE  Interaction: O60341; IntAct: EBI-8468384; Score: 0.37
DE  Interaction: Q9WMX2; IntAct: EBI-9079662; Score: 0.37
DE  Interaction: O14713; IntAct: EBI-10181340; Score: 0.56
DE  Interaction: P05412; IntAct: EBI-11324725; Score: 0.35
DE  Interaction: Q9QWF0; IntAct: EBI-11015136; Score: 0.35
DE  Interaction: Q99576; IntAct: EBI-11128906; Score: 0.35
DE  Interaction: Q9NSG2; IntAct: EBI-11128906; Score: 0.35
DE  Interaction: Q05682; IntAct: EBI-11128906; Score: 0.35
DE  Interaction: Q9H7E2; IntAct: EBI-11128906; Score: 0.35
DE  Interaction: Q96EK4; IntAct: EBI-11128906; Score: 0.35
DE  Interaction: Q96CN9; IntAct: EBI-24633661; Score: 0.56
DE  Interaction: P29401; IntAct: EBI-21539637; Score: 0.35
DE  Interaction: O75366; IntAct: EBI-21577101; Score: 0.35
DE  Interaction: P00740; IntAct: EBI-21577264; Score: 0.35
DE  Interaction: Q9BQ31; IntAct: EBI-21590203; Score: 0.35
DE  Interaction: Q9BTE6; IntAct: EBI-21593012; Score: 0.35
DE  Interaction: Q6IBW4; IntAct: EBI-21600868; Score: 0.35
DE  Interaction: Q6UWQ5; IntAct: EBI-21641185; Score: 0.35
DE  Interaction: Q86YD3; IntAct: EBI-21644294; Score: 0.35
DE  Interaction: Q7Z4W2; IntAct: EBI-21670934; Score: 0.35
DE  Interaction: O15496; IntAct: EBI-21699277; Score: 0.35
DE  Interaction: Q6ZWK4; IntAct: EBI-21782601; Score: 0.35
DE  Interaction: O14593; IntAct: EBI-21807186; Score: 0.35
DE  Interaction: Q96JH7; IntAct: EBI-21840775; Score: 0.35
DE  Interaction: P0CG38; IntAct: EBI-21840775; Score: 0.35
DE  Interaction: P20160; IntAct: EBI-21867396; Score: 0.35
DE  Interaction: B7ZBD5; IntAct: EBI-21871699; Score: 0.35
DE  Interaction: O94808; IntAct: EBI-21881570; Score: 0.35
DE  Interaction: P22105; IntAct: EBI-21892376; Score: 0.40
DE  Interaction: Q9H910; IntAct: EBI-21892399; Score: 0.35
DE  Interaction: P10412; IntAct: EBI-20924530; Score: 0.40
DE  Interaction: Q9H1C4; IntAct: EBI-21266770; Score: 0.35
DE  Interaction: P09613; IntAct: EBI-21497303; Score: 0.35
DE  Interaction: P69479; IntAct: EBI-25568051; Score: 0.35
DE  Interaction: O75874; IntAct: EBI-27039729; Score: 0.37
GO  GO:0005737;
GO  GO:0070062;
GO  GO:0000228;
GO  GO:0005634;
GO  GO:0048471;
GO  GO:0005524;
GO  GO:0016887;
GO  GO:0016787;
GO  GO:0000287;
GO  GO:0008568;
GO  GO:0046034;
GO  GO:0071479;
GO  GO:0007140;
GO  GO:0043066;
GO  GO:2001243;
GO  GO:0001649;
GO  GO:0033687;
GO  GO:0051726;
GO  GO:0010569;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MQTSSSRSVHLSEWQKNYFAITSGICTGPKADAYRAQILRIQYAWANSEISQVCATKLFKKYAEKYSAIIDSDNVESGLN
SQ  NYAENILTLAGSQQTDSDKWQSGLSINNVFKMSSVQKMMQAGKKFKDSLLEPALASVVIHKEATVFDLPKFSVCGSSQES
SQ  DSLPNSAHDRDRTQDFPESNRLKLLQNAQPPMVTNTARTCPTFSAPVGESATAKFHVTPLFGNVKKENHSSAKENIGLNV
SQ  FLSNQSCFPAACENPQRKSFYGSGTIDALSNPILNKACSKTEDNGPKEDSSLPTFKTAKEQLWVDQQKKYHQPQRASGSS
SQ  YGGVKKSLGASRSRGILGKFVPPIPKQDGGEQNGGMQCKPYGAGPTEPAHPVDERLKNLEPKMIELIMNEIMDHGPPVNW
SQ  EDIAGVEFAKATIKEIVVWPMLRPDIFTGLRGPPKGILLFGPPGTGKTLIGKCIASQSGATFFSISASSLTSKWVGEGEK
SQ  MVRALFAVARCQQPAVIFIDEIDSLLSQRGDGEHESSRRIKTEFLVQLDGATTSSEDRILVVGATNRPQEIDEAARRRLV
SQ  KRLYIPLPEASARKQIVINLMSKEQCCLSEEEIEQIVQQSDAFSGADMTQLCREASLGPIRSLQTADIATITPDQVRPIA
SQ  YIDFENAFRTVRPSVSPKDLELYENWNKTFGCGK
//