ID  Q6R755;
PN  Apoptosis regulator Bcl-2;
GN  BCL2;
OS  9615;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0182;
SL  Comments: Mitochondrion outer membrane {ECO:0000250|UniProtKB:P10415}; Single-pass membrane protein {ECO:0000255}. Nucleus membrane {ECO:0000250|UniProtKB:P10415}; Single- pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P10415}; Single-pass membrane protein {ECO:0000255}. Cytoplasm {ECO:0000250|UniProtKB:P10417}.
DR  UNIPROT: Q6R755;
DR  Pfam: PF00452;
DR  Pfam: PF02180;
DR  PROSITE: PS50062;
DR  PROSITE: PS01080;
DR  PROSITE: PS01258;
DR  PROSITE: PS01259;
DR  PROSITE: PS01260;
DR  PROSITE: PS50063;
DE  Function: Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). Also acts as an inhibitor of autophagy: interacts with BECN1 and AMBRA1 during non-starvation conditions and inhibits their autophagy function. May attenuate inflammation by impairing NLRP1- inflammasome activation, hence CASP1 activation and IL1B release. {ECO:0000250|UniProtKB:P10415}.
DE  Reference Proteome: Yes;
GO  GO:0005789;
GO  GO:0016021;
GO  GO:0005741;
GO  GO:0031965;
GO  GO:0046982;
GO  GO:0042803;
GO  GO:0097192;
GO  GO:0008630;
GO  GO:0010507;
GO  GO:2001243;
TP  Membrane Topology: Transmembrane; Source: UniProt - Sequence Analysis {ECO:0000255};
SQ  MAQAGRTGYDNREIVMKYIHYKLSQRGYEWDVGDVDAAPLGAAPTPGIFSFQPESNPTPAVHRDMAARTSPLRPIVATTG
SQ  PTLSPVPPVVHLTLRRAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVN
SQ  REMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYGPTMQPLFDFSWLSLKALLSLALVGACITLGAYLGHK
//