ID  Q6X2U4;
PN  RNA-directed RNA polymerase p90;
GN  POLN;
OS  376262;
SL  Nucleus Position: SL-0382;
SL  Comments: [Non-structural polyprotein p200]: Host membrane {ECO:0000250|UniProtKB:Q86500}. Host cytoplasm, host perinuclear region {ECO:0000250|UniProtKB:Q86500}. Host cytoplasm {ECO:0000250|UniProtKB:Q86500}. Note=Localizes to cytoplasmic foci at 24 hpi. {ECO:0000250|UniProtKB:Q86500}. [Protease/methyltransferase p150]: Host membrane {ECO:0000250|UniProtKB:Q86500}. Host cytoplasm, host perinuclear region {ECO:0000250|UniProtKB:Q86500}. Host cytoplasm {ECO:0000250|UniProtKB:Q86500}. Note=At 36 hpi, localizes to the host cytoplasm, probably in vesicles inside host vacuoles of endosomal and lysosomal origin (By similarity). At 72 hpi, localizes to filamentous structures in the host cytoplasm (By similarity). {ECO:0000250|UniProtKB:P13889, ECO:0000250|UniProtKB:Q86500}. [RNA-directed RNA polymerase p90]: Host membrane {ECO:0000250|UniProtKB:Q86500}. Host cytoplasm {ECO:0000250|UniProtKB:Q86500}. Note=Localizes to the cytoplasm and to the cytoplasmic fibers formed by protease/methyltransferase p150. {ECO:0000250|UniProtKB:Q86500}.
DR  UNIPROT: Q6X2U4;
DR  Pfam: PF01661;
DR  Pfam: PF05407;
DR  Pfam: PF00978;
DR  Pfam: PF12601;
DR  Pfam: PF01443;
DR  PROSITE: PS51743;
DR  PROSITE: PS51154;
DR  PROSITE: PS51657;
DR  PROSITE: PS50507;
DR  PROSITE: PS51889;
DE  Function: [Non-structural polyprotein p200]: Probable principal replicase for the negative-strand DNA, which replicates the 40S (+) genomic RNA into (-) antigenomic RNA. It cannot replicate the (-) into (+) until cleaved into p150 and p90 mature proteins. {ECO:0000250|UniProtKB:Q86500}. [Protease/methyltransferase p150]: Protease that cleaves the precursor polyprotein into two mature products. Together with RNA- directed RNA polymerase p90, replicates the 40S genomic and antigenomic RNA by recognizing replications specific signals. The heterodimer P150/p90 is probably the principal replicase for positive-strand genomic RNA and the 24S subgenomic RNA, which codes for structural proteins. Responsible for the mRNA-capping of the viral mRNAs. This function is necessary since all viral RNAs are synthesized in the cytoplasm, and host capping enzymes are restricted to the nucleus. Forms fibers late in the infection that may be involved in cell-to-cell spread of the virus RNA in the absence of virus particle formation. {ECO:0000250|UniProtKB:Q86500}. [RNA-directed RNA polymerase p90]: Together with protease/methyltransferase p150, replicates the 40S genomic and antigenomic RNA by recognizing replications specific signals. The heterodimer P150/p90 is probably the principal replicase for positive- strand genomic RNA and the 24S subgenomic RNA, which codes for structural proteins. A helicase activity is probably also present. {ECO:0000250|UniProtKB:Q86500}.
DE  Reference Proteome: No;
GO  GO:0033644;
GO  GO:0044220;
GO  GO:0016020;
GO  GO:0005524;
GO  GO:0016887;
GO  GO:0004197;
GO  GO:0046872;
GO  GO:0008174;
GO  GO:0003723;
GO  GO:0003724;
GO  GO:0003968;
GO  GO:0006351;
GO  GO:0006508;
GO  GO:0006396;
GO  GO:0039694;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MEKLLDEVLAPGGPYNLTVGSWVRDHVRSIVEGAWEVRDVVTAAQKRAIVAVIPRPVFTQMQVSDHPALHAISRYTRRHW
SQ  IEWGPKEALHVLIDPSPGLLREVARVERRWVALCLHRTARKLATALAETAGEAWHADYVCALRGAPSGPFYVHPEDVPRG
SQ  GRAVADRCLLYYTPMQMCELMRTIDATLLVAVDLWPVALAAHVGDDWDDLGIAWHLDHDGGCPADCRGAGAGPTPGYTRP
SQ  CTTRIYQVLPDTAHPGRLYRCGPRLWTRDCAVAELSWEVAQHCGHQARVRAVRCTLPIRHVRSLQPSARVRLPDLVHLAE
SQ  VGRWRWFSLPRPVFQRMLSYCKTLSPDAYYSERVFKFKNALSHSITLAGNVLQEGWKGTCAEEDALCAYVAFRAWQSNAR
SQ  LAGIMKGAKRCAADSLSVAGWLDTIWDAIKRFFGSVPLAERMEEWEQDAAVAAFDRGPLEDGGHHLDTVQPPKPLPRPEI
SQ  AATWIVHAASADRHCACAPRCDVPRERPSAPAGPPDDEALIPPWLFAERRTLRCREWDFEALRARADTAATPAPLAPRPA
SQ  RYPTVLYRHPAHHGPWLTLDEPGEADAALVLCDPLGQPLRGPERHFAAGAHMCAQARGLQAFVRVVPPPERPWADGGART
SQ  WAKFFRGCAWAQRLLGEPAVMHLPYTDGDVPQLIALALRTLAQQGAALALSVRDLPGGAAFDANAVTAAVRADPGQLALT
SQ  SPPPDNPPPPRRARRSQRHADARGPPPPAPVRDPPPLPPSPPAPRRAGDPASPISAEPADRARDAEPEVACEPGGPATPT
SQ  RADPDSDIVESYARAAGPVHLRVRNIMDPPPGCKVVVNAANEGLLAGSGVCGAIFASAAATLAEDCRRLAPCPTGEAVAT
SQ  PGHGCGYTHIIHAVAPRRPQDPAALEQSEALLERAYRSVVALAAARRWACVACPLLGAGIYGWSAAESLRAALAAARTEP
SQ  AERVSLHICHPDRATLMHASVLVGAGLAARRVSPPPTEPLASCPADDPGRSTQRTASPPAAPPGDAAAPESRGCQGCELC
SQ  RYTRVTNDRAYVNLWLERDRGATGWAMRIPEVVVYGPEHLAAHFPLNHYSVLKPAEVRPPRGMCGSDMWRCRGWQGMPQV
SQ  RCTPSNAHAALCRIGIPPRVSTRGDERDPNTCWLRAAANVAQAARACGAYTSAGCPKCAYGRALSEARTHEAFAALSQRW
SQ  IASHADASLDGTGDPLDPLMETVGCACSRVWVGSEHEAPPDHLLVSLHRAPNGPWGVVLEVRARPEGGNPTGHFVCAVGG
SQ  GPRRVSDRPHLWLAVPLSRGGGTCAATDEGLAQAYYDDLEVRRLGDDAMARAALASVQRPRKGPYNIKVWNMAAGAGKTT
SQ  RILAAFTREDLYVCPTNALLHEIQAKLRARDIDIKNAATYERALTKPLAAYRRIYIDEAFTLGGEYCAFVASQTTAEVIC
SQ  VGDRDQCGPHYANNCRTPVPDRWPTERSRHTWRFPDCWAARLRAGLDYDVEGEHAGTFACNLWDGRQVDLHLAFSRETVR
SQ  RLHEAGIRAYTVREAQGMSVGTACIHVGRDGTDVALALTRDLAIVSLTRASDALYLHELEDGSLRAAGLSAFLDAGALAE
SQ  LKEVPAGIDRVVAVEQAPPPLPPADGIPEAQDVPPFCPRTLEELVFGRAGHPHYADLNRVTEGEREVRYMRISRHLLNKN
SQ  HTEMPGTERVLSAVCAVRRYRAGEDGSTLRTAVARQHPRPFRQIPPPRVTAGVAQEWRMTYLRERIDLTDVYTQMGVAAR
SQ  ELTDRYARRYPEIFAGMCTAQSLSVPAFLKATLKCVDAALGPRDTEDCHAAQGKAGLEIRAWAKEWVQVMSPHFRAIQKI
SQ  IMRALRPQFLVAAGHTEPEVDAWWQAHYTTNAIEVDFTEFDMNQTLATRDVELEISAALLGLPCAEDYRALRAGSYCTLR
SQ  ELGSTETGCERTSGEPATLLHNTTVAMCMAMRMVPKGVRWAGIFQGDDMVIFLPEGARSAALKWTPSEVGLFGFHIPVKH
SQ  VSTPTPSFCGHVGTAAGLFHDVMHQAIKVLCRRFDPDVLEEQQVALLDRLRGVYAALPDTVAANAAYYDYSAERVLAIVR
SQ  ELTAYARGRGLDHPATIGALEEIQTPYARANLHDAD
//