ID  Q6Y5D8;
PN  Rho GTPase-activating protein 10;
GN  Arhgap10;
OS  10090;
SL  Nucleus Position: SL-0198;
SL  Comments: Cytoplasm. Cytoplasm, perinuclear region. Cell membrane. Note=Association to cell membrane is dependent on PH domain.
DR  UNIPROT: Q6Y5D8;
DR  UNIPROT: Q6Y5D6;
DR  UNIPROT: Q6Y5D7;
DR  UNIPROT: Q99MT3;
DR  UNIPROT: Q99MT4;
DR  Pfam: PF00169;
DR  Pfam: PF00620;
DR  Pfam: PF14604;
DR  PROSITE: PS50003;
DR  PROSITE: PS50238;
DR  PROSITE: PS50002;
DE  Function: GTPase activator for the small GTPases RhoA and Cdc42 by converting them to an inactive GDP-bound state. Essential for PTKB2 regulation of cytoskeletal organization via Rho family GTPases. Inhibits PAK2 proteolytic fragment PAK-2p34 kinase activity and changes its localization from the nucleus to the perinuclear region. Stabilizes PAK-2p34 thereby increasing stimulation of cell death. {ECO:0000269|PubMed:11238453, ECO:0000269|PubMed:15471851}.
DE  Reference Proteome: Yes;
DE  Interaction: Q29502; IntAct: EBI-4396533; Score: 0.53
GO  GO:0005829;
GO  GO:0048471;
GO  GO:0005886;
GO  GO:0005096;
GO  GO:0007010;
GO  GO:0043066;
GO  GO:0007165;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MGLQPLEFSDCYLDSPWFRERIRAHEAELERTNKFIKELIKDGKNLISATKSLSAAQRKFAHSLRDFKFEFIGDAETDDE
SQ  RCIDASLREFSNFLKNLEEQREIMALSVTETLIKPLEKFRKEQLGAVKEEKKKFDKETEKNYSLIDKHLTLSARKKDSHL
SQ  QEADLQVEQNRQHFYELSLEYVCKLQEIQERKKFEFVEPMLSFFQGMFTFYHQGHELSKDFNHYKMELQINIQNTRNRFE
SQ  GTRSEVEELMNKIRQNPKDQKRASQFTAEGYLYVQEKRPAPFGSSWVKHYCMYRKTAKKFNMIPFEHRSGGKLGDGEAFF
SQ  LKECTKRHMDSTDRRFCFDIEAADRPGVPLTVQAFSEEERKQWLEALGGKEALFHTFNRAIVPRPEGGAQLDKMGFTILR
SQ  KCISAVETRGINDQGLYRVVGVSSKVQRLLSMLMDVKMCNELDLENSADWEVKTVTSALKQYLRSLPEPLMTYELHRDFI
SQ  VPAKSGSPESRVNAIHFLVHKLPEKNKEMLDILVKHLTNVSSHSKQNLMTVANLGVVFGPTLMRPQEETVAAIMDLKFQN
SQ  IVVEILIENHEKIFRTSPDTTFAEPTCLSASPPNAPPRQSKRQGQRTKRPVAVYNLCLELEEGDSPSPLKEDPPSSSQDS
SQ  LSTPSPTTSAAHGPPGLDGNHLAADGGSCGDATATTPSQTRPSMVQWLNMQSPTTPSSNPAGTPPSPRMSPFPLSPAASI
SQ  VDKLPECVINRKARAVYPCEAEHSSELSFEIGAIFEDVQTSREPGWLEGTLNGKRGLIPQNYVKLL
//