ID  Q6ZPJ0;
PN  Testis-expressed protein 2;
GN  Tex2;
OS  10090;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0182;
SL  Comments: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q06833}; Multi-pass membrane protein {ECO:0000255}. Nucleus membrane {ECO:0000250|UniProtKB:Q06833}; Multi- pass membrane protein {ECO:0000255}. Note=Enriched at the nucleus- vacuole junction (By similarity). During endoplasmic reticulum (ER) stress, localizes to ER-Golgi contacts (By similarity). {ECO:0000250|UniProtKB:Q06833, ECO:0000250|UniProtKB:Q8IWB9}.
DR  UNIPROT: Q6ZPJ0;
DR  UNIPROT: B1ATR1;
DR  PROSITE: PS51847;
DE  Function: During endoplasmic reticulum (ER) stress or when cellular ceramide levels increase, may induce contacts between the ER and medial-Golgi complex to facilitate non-vesicular transport of ceramides from the ER to the Golgi complex where they are converted to complex sphingolipids, preventing toxic ceramide accumulation. {ECO:0000250|UniProtKB:Q8IWB9}.
DE  Reference Proteome: Yes;
DE  Interaction: Q6NZM9; IntAct: EBI-26471757; Score: 0.35
GO  GO:0005783;
GO  GO:0005789;
GO  GO:0016021;
GO  GO:0031965;
GO  GO:0008289;
GO  GO:0006869;
TP  Membrane Topology: Transmembrane; Source: UniProt - Sequence Analysis {ECO:0000255};
SQ  MTSLNGRHAEKTIDMPKPSAPKVHVQRSVSRDTIAIHFSASGEEEEEEEEEFRGYLEEGLDDQSIVTGLEAKEDLYLESQ
SQ  GGHDPAGPVSTAPADGLSVSESPAILPVSENTVKLLESPAPALQVLSPVPLALSPGSSSSGPLASSPSVSSLSEQKTSSS
SQ  SPLSSPSKSPVLSSSASSSALSSAKPFMSLVKSLSTEVEPKESPHPPRHRHLMKTLVKSLSTDTSRQESDTVSYKPPDSK
SQ  LNLHLFKQFTQPRNTGGDSKTAPSSPLTSPSDTRSFFKVPEMEAKIEDTKRRLSEVIYEPFQLLSKIIGEESGSHRPKAL
SQ  SASASELSSLSGLNGHLESNNYSIKEEEGDSEGEGYGSDSNTSRSDHLKPTEDASKEVEPKGSQASSLKDLGLKTSSLVL
SQ  EKCSLSALVSKEDEEFCELYTEDFELETEGEGRLDKTLDLPLKPEVLASDGVALESEDEEDSATEHQELPVKTLGFFIMC
SQ  VYAYLILPLPYYMSGLFLGVGLGFMTAVCMIWFFTPPSAHKHHKSLKALRHQSTRSLDIKEPEILKGWMNEIYNYDPETY
SQ  HATLTHSVFVRLEGGTLRLSKPNKNISRRASYNETKPEVTYISQKIYDLSDSKIYLVPKSLARKRIWNKKYPICIELGRQ
SQ  DDFMSKAQSDKEATEEKPPPEKELPSEDLKKPPQPQEGTKSSQRDPILYLFGRTGREKEEWFRRFILASRLKSELRKPAG
SQ  VSGSKSGLLPAHSRHSSPSGHLSHSRSSSKGSVEEMMSQPKQKELVGSVRQKMLLDYSVYMGRCVPQDNRSPHRSPVQSA
SQ  ESSPTASKKLPEAPPSEEEEQEAWVNALLGRIFWDFLGEKYWSDVVSKKIQMKLSKIKLPYFMNELTLTELDMGVAVPKI
SQ  LQAFKPYVDHQGLWIDLEMSYNGSFLMTLETKMNLTKLGKEPLVEALKVGEIGKEGCRPRAYCLADSDEESSSAGSSEED
SQ  DPPEPTAGDKQPLPGAEGYVGGHRTSKIMRFVDKITKSKYFQKATETEFIKKKIEEVSNTPLLLTVEVQECRGTLAVNIP
SQ  PPPTDRIWYGFRKPPYVELKARPKLGEREVTLVHVTEWIEKKLEQELQKVFVMPNMDDVYIPIMHSAMDPRSTSCLLKEP
SQ  PVETSDQL
//