ID  Q6ZQE4;
PN  Nuclear envelope integral membrane protein 1;
GN  Nemp1;
OS  10090;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0179;
SL  Nucleus Position: SL-0182;
SL  Comments: Nucleus inner membrane {ECO:0000269|PubMed:25946333}; Multi-pass membrane protein {ECO:0000255}; Nucleoplasmic side {ECO:0000250|UniProtKB:B9X187}. Nucleus envelope {ECO:0000269|PubMed:25946333}. Note=Colocalizes with lamins and RAN-GTP at the nuclear envelope. {ECO:0000269|PubMed:25946333}.
DR  UNIPROT: Q6ZQE4;
DR  Pfam: PF10225;
DE  Function: Together with EMD, contributes to nuclear envelope stiffness in germ cells (PubMed:32923640). Required for female fertility (PubMed:32923640). {ECO:0000269|PubMed:32923640}.
DE  Reference Proteome: Yes;
DE  Interaction: P62827; IntAct: EBI-12595973; Score: 0.60
DE  Interaction: P63280; IntAct: EBI-12598469; Score: 0.37
GO  GO:0016021;
GO  GO:0005635;
GO  GO:0005637;
GO  GO:0071763;
TP  Membrane Topology: Transmembrane; Source: UniProt - Sequence Analysis {ECO:0000255};
SQ  MAGGIKVSVWSAVGPGPRCWGAGGGGGATWLLLVVAGCVVCGSADVNVVMLQESQVDMNSSQQFCYKNVLIPKWHDIWTR
SQ  IQVRVNSSKLVRVTQVDNEEKLKELEQFSIWNFFSSFLKEKLNDTYVNVGLYSTKTCLKVEMIEKDTTYSVTVTRRFDPK
SQ  LFLVFLLGLTLFFCGDLLSRSQIFYYSTGMSVGIVASLLIVIFMISKFMPKRSPIYVILVGGWSFSLYLIQLVFKNLQEI
SQ  WRSYWHYLLSYILTVGFMSFAVCYKYGPLENERSINLLTWTLQLLGLGLMYSSIQIPHVAFALIVIALCTKNLEYPIHWL
SQ  CSTYRRMCKASGKPVPPRLLTEEEYRIQGEVETQKALQELREFCNSPECSAWKTISRIQSPKRFADFVEGSFHLTPNEVS
SQ  VHEQEYGLGSIFTQDEELSSEEEGSEYPTFTQNNFLT
//