ID  Q6ZRP7;
PN  Sulfhydryl oxidase 2;
GN  QSOX2;
OS  9606;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0182;
SL  Comments: Membrane {ECO:0000269|PubMed:14633699}; Single- pass membrane protein {ECO:0000269|PubMed:14633699}. Secreted {ECO:0000269|PubMed:14633699}. Cell membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Nucleus membrane {ECO:0000305}; Single- pass membrane protein {ECO:0000305}. Note=Seems to be predominantly targeted to the nuclear and outer plasma membrane.
DR  UNIPROT: Q6ZRP7;
DR  UNIPROT: A2CEE0;
DR  UNIPROT: A6NLB0;
DR  UNIPROT: Q5TB37;
DR  UNIPROT: Q7Z7B6;
DR  UNIPROT: Q86VV7;
DR  UNIPROT: Q8N3G2;
DR  Pfam: PF04777;
DR  Pfam: PF18371;
DR  Pfam: PF18108;
DR  Pfam: PF00085;
DR  PROSITE: PS51324;
DR  PROSITE: PS51352;
DR  OMIM: 612860;
DR  DisGeNET: 169714;
DE  Function: Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. May contribute to disulfide bond formation in a variety of secreted proteins. Also seems to play a role in regulating the sensitization of neuroblastoma cells for interferon-gamma-induced apoptosis. {ECO:0000269|PubMed:14633699}.
DE  Reference Proteome: Yes;
DE  Interaction: K9N7C7; IntAct: EBI-26374966; Score: 0.35
DE  Interaction: P0C6X7; IntAct: EBI-26377188; Score: 0.35
DE  Interaction: P0DTD1; IntAct: EBI-25491011; Score: 0.53
DE  Interaction: Q99614; IntAct: EBI-11127397; Score: 0.35
DE  Interaction: Q5VYS8; IntAct: EBI-11127397; Score: 0.35
DE  Interaction: Q9C0F1; IntAct: EBI-11127397; Score: 0.35
DE  Interaction: Q8IZH2; IntAct: EBI-11127397; Score: 0.35
DE  Interaction: Q86YS7; IntAct: EBI-11127397; Score: 0.35
DE  Interaction: Q12824; IntAct: EBI-11127397; Score: 0.35
DE  Interaction: Q9UBD5; IntAct: EBI-11127397; Score: 0.35
DE  Interaction: Q6ZNJ1; IntAct: EBI-11127397; Score: 0.35
DE  Interaction: F8VY35; IntAct: EBI-11127397; Score: 0.35
DE  Interaction: Q9P2X3; IntAct: EBI-11127397; Score: 0.35
DE  Interaction: Q9Y6K0; IntAct: EBI-11127397; Score: 0.35
DE  Interaction: Q8TB52; IntAct: EBI-11127397; Score: 0.35
DE  Interaction: Q20MH8; IntAct: EBI-12586007; Score: 0.35
DE  Interaction: Q8IWL3; IntAct: EBI-13943458; Score: 0.35
DE  Interaction: P20036; IntAct: EBI-21511890; Score: 0.35
DE  Interaction: Q9NRD5; IntAct: EBI-21519718; Score: 0.35
DE  Interaction: P05161; IntAct: EBI-16720078; Score: 0.35
DE  Interaction: P69479; IntAct: EBI-25568051; Score: 0.35
DE  Interaction: P0DTD8; IntAct: EBI-25687199; Score: 0.35
DE  Interaction: Q7TFA1; IntAct: EBI-25688644; Score: 0.35
DE  Interaction: Q2TAZ0; IntAct: EBI-26443127; Score: 0.35
DE  Interaction: Q9H5K3; IntAct: EBI-28948637; Score: 0.35
DE  Interaction: P08069; IntAct: EBI-32718669; Score: 0.35
DE  Interaction: P06213; IntAct: EBI-32718777; Score: 0.35
DE  Interaction: Q16288; IntAct: EBI-32719212; Score: 0.35
DE  Interaction: P09619; IntAct: EBI-32719373; Score: 0.35
DE  Interaction: Q06418; IntAct: EBI-32719716; Score: 0.35
GO  GO:0005615;
GO  GO:0005794;
GO  GO:0030173;
GO  GO:0031965;
GO  GO:0005654;
GO  GO:0005886;
GO  GO:0016971;
GO  GO:0003756;
GO  GO:0006457;
TP  Membrane Topology: Transmembrane; Source: UniProt - Sequence Analysis {ECO:0000255};
SQ  MAAAGAAVARSPGIGAGPALRARRSPPPRAARLPRLLVLLAAAAVGPGAGGAARLYRAGEDAVWVLDSGSVRGATANSSA
SQ  AWLVQFYSSWCGHCIGYAPTWRALAGDVRDWASAIRVAALDCMEEKNQAVCHDYDIHFYPTFRYFKAFTKEFTTGENFKG
SQ  PDRELRTVRQTMIDFLQNHTEGSRPPACPRLDPIQPSDVLSLLDNRGSHYVAIVFESNSSYLGREVILDLIPYESIVVTR
SQ  ALDGDKAFLEKLGVSSVPSCYLIYPNGSHGLINVVKPLRAFFSSYLKSLPDVRKKSLPLPEKPHKEENSEIVVWREFDKS
SQ  KLYTVDLESGLHYLLRVELAAHKSLAGAELKTLKDFVTVLAKLFPGRPPVKKLLEMLQEWLASLPLDRIPYNAVLDLVNN
SQ  KMRISGIFLTNHIKWVGCQGSRSELRGYPCSLWKLFHTLTVEASTHPDALVGTGFEDDPQAVLQTMRRYVHTFFGCKECG
SQ  EHFEEMAKESMDSVKTPDQAILWLWKKHNMVNGRLAGHLSEDPRFPKLQWPTPDLCPACHEEIKGLASWDEGHVLTFLKQ
SQ  HYGRDNLLDTYSADQGDSSEGGTLARGEEEEKRLTPPEVSHGDRDTQSVRPPGALGPRPALPESLHHSLDGKLQSLDGPG
SQ  AHKEVGGAAPFLGVDFSSLDMSLCVVLYVASSLFLMVMYFFFRVRSRRWKVKHHHPAV
//