ID  Q7JRE4;
PN  Inner nuclear membrane protein Man1;
GN  MAN1;
OS  7227;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0179;
SL  Nucleus Position: SL-0182;
SL  Comments: Nucleus inner membrane {ECO:0000269|PubMed:16439308}; Multi-pass membrane protein {ECO:0000269|PubMed:16439308}. Cytoplasm {ECO:0000269|PubMed:16439308}. Nucleus, nucleoplasm {ECO:0000269|PubMed:16439308}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:16439308}. Note=During anaphase and metaphase, detected in the nuclear envelope and spindle poles. {ECO:0000269|PubMed:16439308}.
DR  UNIPROT: Q7JRE4;
DR  UNIPROT: Q961B2;
DR  Pfam: PF03020;
DR  PROSITE: PS50954;
DE  Function: Inner nuclear membrane protein (PubMed:16439308). Acts as a negative regulator of the BMP (Dpp) signaling cascade during crossvein development in pupal wings and possibly during synaptic transmission at the neuromuscular junction (NMJ) (PubMed:18723885, PubMed:20036230). Appears to be required for pupal development and consequently transition to the adult stage (PubMed:18723885, PubMed:20036230). During pupal development, plays essential and redundant functions with the other LEM domain proteins; bocks and Ote (PubMed:24700158). {ECO:0000269|PubMed:16439308, ECO:0000269|PubMed:18723885, ECO:0000269|PubMed:20036230, ECO:0000269|PubMed:24700158}.
DE  Reference Proteome: Yes;
DE  Interaction: P18431; IntAct: EBI-9925534; Score: 0.35
GO  GO:0005737;
GO  GO:0012505;
GO  GO:0005639;
GO  GO:0005654;
GO  GO:0000922;
GO  GO:0031490;
GO  GO:0030514;
GO  GO:0006998;
GO  GO:1902531;
TP  Membrane Topology: Transmembrane; Source: UniProt - Sequence Analysis {ECO:0000255};
SQ  MSTESLNSLSDKELHRKLIQSGFPSTPVTETTRAVLIEKLRKHTRADKLKKRSNKYVLYSKEQQESPPFPQYHQYHAPQP
SQ  PQNYANGLDNNNDLDQTGGSSAYNRSLDESDSSPLQLSASKMYAPPPVVASNYDGDCSPHSLGLNGKYLQPCSMPYAIDT
SQ  SNNYGKPSGKAKLSDGGVVNRLLSFRDTTIQRKFNYPTGQASRIPLRKERLTRFALSDLKSFIRNPDIRPYVIPRVLISL
SQ  FLIFLTIITVLYVGKRFEQSPIDKAALKYTLCNPNDMQMISEKVNCIEKDSLRGALDMSEELFRHLNERARLHHCKDANL
SQ  SPALEIGEFVREMVSNPKTHRGNLHSNLMAAKYLITENPQWSIQVVDSTKHLGQTSHFELSEPNLPLKCIVLKKVTRFFT
SQ  VIGALLLIVAGFLIVYVAVVIYRVKQKEALLAVDQFQKDIINELIYLSSQSESPEVVINQLQEKFLPAKKRSKLLSSWNK
SQ  ALKQLEKNDSRVLFGMVNRDGKAMRTIAWNRNVDKKDVGLVKKWQSPAFDNSNKIANPPTPCLKIRHMFDSSEVDQANLK
SQ  QSIVESIIEKVGTRCKICDVQLDVQSCCVYIRCASEEDAGTIHKEINGWWFDKRLISIKFLRLERYLSRFPKPSAEPLYF
SQ  HTNEAANTHS
//