ID  Q7L5L3;
PN  Lysophospholipase D GDPD3;
GN  GDPD3;
OS  9606;
SL  Nucleus Position: SL-0198;
SL  Comments: Membrane {ECO:0000250|UniProtKB:Q99LY2}; Multi- pass membrane protein {ECO:0000250|UniProtKB:Q99LY2}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q99LY2}. Endoplasmic reticulum {ECO:0000269|PubMed:27637550}. Note=Partially co-localized with CANX. {ECO:0000250|UniProtKB:Q99LY2}.
DR  UNIPROT: Q7L5L3;
DR  UNIPROT: Q9H652;
DR  Pfam: PF03009;
DR  PROSITE: PS51704;
DR  OMIM: 616318;
DR  DisGeNET: 79153;
DE  Function: Hydrolyzes lysoglycerophospholipids to produce lysophosphatidic acid (LPA) and the corresponding amines (PubMed:27637550). Shows a preference for 1-O-alkyl-sn-glycero-3- phosphocholine (lyso-PAF), lysophosphatidylcholine (lyso-PC) and N- acylethanolamine lysophospholipids (PubMed:27637550). Does not display glycerophosphodiester phosphodiesterase activity, since it cannot hydrolyze either glycerophosphoinositol or glycerophosphocholine. {ECO:0000250|UniProtKB:Q99LY2, ECO:0000269|PubMed:27637550}.
DE  Reference Proteome: Yes;
DE  Interaction: Q13617; IntAct: EBI-21327106; Score: 0.35
DE  Interaction: P01160; IntAct: EBI-21572983; Score: 0.35
DE  Interaction: Q5VU43; IntAct: EBI-21573806; Score: 0.35
DE  Interaction: Q15915; IntAct: EBI-21696712; Score: 0.35
DE  Interaction: Q8IW40; IntAct: EBI-21747275; Score: 0.35
DE  Interaction: O43918; IntAct: EBI-21790262; Score: 0.35
DE  Interaction: O43781; IntAct: EBI-28931148; Score: 0.35
DE  Interaction: O95382; IntAct: EBI-28931448; Score: 0.35
DE  Interaction: P54619; IntAct: EBI-28938518; Score: 0.35
DE  Interaction: Q14296; IntAct: EBI-28941126; Score: 0.35
DE  Interaction: Q8IVW4; IntAct: EBI-28942376; Score: 0.35
GO  GO:0005783;
GO  GO:0005789;
GO  GO:0070062;
GO  GO:0016021;
GO  GO:0048471;
GO  GO:0004622;
GO  GO:0046872;
GO  GO:0008081;
GO  GO:0046475;
GO  GO:0070291;
GO  GO:0034638;
TP  Membrane Topology: Transmembrane; Source: UniProt - Sequence Analysis {ECO:0000255};
SQ  MSLLLYYALPALGSYAMLSIFFLRRPHLLHTPRAPTFRIRLGAHRGGSGELLENTMEAMENSMAQRSDLLELDCQLTRDR
SQ  VVVVSHDENLCRQSGLNRDVGSLDFEDLPLYKEKLEVYFSPGHFAHGSDRRMVRLEDLFQRFPRTPMSVEIKGKNEELIR
SQ  EIAGLVRRYDRNEITIWASEKSSVMKKCKAANPEMPLSFTISRGFWVLLSYYLGLLPFIPIPEKFFFCFLPNIINRTYFP
SQ  FSCSCLNQLLAVVSKWLIMRKSLIRHLEERGVQVVFWCLNEESDFEAAFSVGATGVITDYPTALRHYLDNHGPAARTS
//