ID  Q7L5N1;
PN  COP9 signalosome complex subunit 6;
GN  COPS6;
OS  9606;
SL  Nucleus Position: SL-0198;
SL  Comments: Nucleus {ECO:0000269|PubMed:9535219}. Cytoplasm {ECO:0000269|PubMed:9535219}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:9520381}. Note=(Microbial infection) The interaction with HIV-1 Vpr protein possibly leads its translocation to a perinuclear region. {ECO:0000269|PubMed:9520381}.
DR  UNIPROT: Q7L5N1;
DR  UNIPROT: A4D2A3;
DR  UNIPROT: O15387;
DR  PDB: 4D10;
DR  PDB: 4D18;
DR  PDB: 4QFT;
DR  PDB: 4R14;
DR  PDB: 4WSN;
DR  PDB: 6R6H;
DR  PDB: 6R7F;
DR  PDB: 6R7H;
DR  PDB: 6R7I;
DR  Pfam: PF01398;
DR  Pfam: PF13012;
DR  PROSITE: PS50249;
DR  OMIM: 614729;
DR  DisGeNET: 10980;
DE  Function: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF- type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Has some glucocorticoid receptor-responsive activity. Stabilizes COP1 through reducing COP1 auto-ubiquitination and decelerating COP1 turnover rate, hence regulates the ubiquitination of COP1 targets. {ECO:0000269|PubMed:11285227, ECO:0000269|PubMed:11337588, ECO:0000269|PubMed:12628923, ECO:0000269|PubMed:12732143, ECO:0000269|PubMed:21625211, ECO:0000269|PubMed:9535219}.
DE  Reference Proteome: Yes;
DE  Interaction: O75569; IntAct: EBI-730597; Score: 0.00
DE  Interaction: P04406; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: P11802; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: P49454; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: P50402; IntAct: EBI-731797; Score: 0.00
DE  Interaction: P78406; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: Q3TLR7; IntAct: EBI-2562304; Score: 0.40
DE  Interaction: Q5JTH9; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: P40425; IntAct: EBI-348673; Score: 0.00
DE  Interaction: P08670; IntAct: EBI-475271; Score: 0.37
DE  Interaction: P14174; IntAct: EBI-7523063; Score: 0.40
DE  Interaction: Q9BX70; IntAct: EBI-2510262; Score: 0.75
DE  Interaction: Q96RU7; IntAct: EBI-729666; Score: 0.00
DE  Interaction: Q96HD1; IntAct: EBI-729816; Score: 0.00
DE  Interaction: O43261; IntAct: EBI-729873; Score: 0.00
DE  Interaction: Q3KQU3; IntAct: EBI-729987; Score: 0.00
DE  Interaction: Q9GZN7; IntAct: EBI-730002; Score: 0.00
DE  Interaction: Q16363; IntAct: EBI-730249; Score: 0.00
DE  Interaction: Q15102; IntAct: EBI-730441; Score: 0.00
DE  Interaction: Q6P1K2; IntAct: EBI-730531; Score: 0.00
DE  Interaction: O00231; IntAct: EBI-730615; Score: 0.00
DE  Interaction: P40937; IntAct: EBI-730663; Score: 0.00
DE  Interaction: P15927; IntAct: EBI-730690; Score: 0.00
DE  Interaction: P21673; IntAct: EBI-730750; Score: 0.00
DE  Interaction: P50453; IntAct: EBI-730786; Score: 0.00
DE  Interaction: P62308; IntAct: EBI-730870; Score: 0.00
DE  Interaction: P04183; IntAct: EBI-7396449; Score: 0.55
DE  Interaction: P17028; IntAct: EBI-731131; Score: 0.00
DE  Interaction: Q96SN7; IntAct: EBI-731467; Score: 0.00
DE  Interaction: Q9Y6N8; IntAct: EBI-731527; Score: 0.00
DE  Interaction: P42773; IntAct: EBI-731554; Score: 0.00
DE  Interaction: Q14061; IntAct: EBI-731602; Score: 0.00
DE  Interaction: P20674; IntAct: EBI-731608; Score: 0.00
DE  Interaction: Q53FE4; IntAct: EBI-731683; Score: 0.00
DE  Interaction: O14717; IntAct: EBI-731731; Score: 0.00
DE  Interaction: P05305; IntAct: EBI-731764; Score: 0.00
DE  Interaction: Q09472; IntAct: EBI-731824; Score: 0.00
DE  Interaction: P84090; IntAct: EBI-731839; Score: 0.00
DE  Interaction: Q9NY59; IntAct: EBI-731947; Score: 0.00
DE  Interaction: P30519; IntAct: EBI-732133; Score: 0.00
DE  Interaction: Q9BWC9; IntAct: EBI-732208; Score: 0.00
DE  Interaction: P06858; IntAct: EBI-732383; Score: 0.00
DE  Interaction: Q13113; IntAct: EBI-732452; Score: 0.00
DE  Interaction: Q8IYB7; IntAct: EBI-732497; Score: 0.00
DE  Interaction: Q8N2I9; IntAct: EBI-732509; Score: 0.00
DE  Interaction: P51948; IntAct: EBI-732533; Score: 0.00
DE  Interaction: Q99417; IntAct: EBI-732572; Score: 0.00
DE  Interaction: P09466; IntAct: EBI-732710; Score: 0.00
DE  Interaction: P17858; IntAct: EBI-732806; Score: 0.00
DE  Interaction: Q92561; IntAct: EBI-732833; Score: 0.00
DE  Interaction: P07602; IntAct: EBI-732965; Score: 0.00
DE  Interaction: P60484; IntAct: EBI-733013; Score: 0.00
DE  Interaction: Q9BXR0; IntAct: EBI-733043; Score: 0.00
DE  Interaction: P51159; IntAct: EBI-733067; Score: 0.00
DE  Interaction: P11166; IntAct: EBI-733325; Score: 0.00
DE  Interaction: Q16637; IntAct: EBI-7388742; Score: 0.55
DE  Interaction: Q13190; IntAct: EBI-733412; Score: 0.00
DE  Interaction: P49888; IntAct: EBI-733421; Score: 0.00
DE  Interaction: P13385; IntAct: EBI-733511; Score: 0.00
DE  Interaction: O60315; IntAct: EBI-733740; Score: 0.00
DE  Interaction: Q9Y4P8; IntAct: EBI-734305; Score: 0.00
DE  Interaction: P62861; IntAct: EBI-734475; Score: 0.00
DE  Interaction: Q8IYL3; IntAct: EBI-734959; Score: 0.00
DE  Interaction: P61313; IntAct: EBI-21328549; Score: 0.55
DE  Interaction: P60903; IntAct: EBI-735711; Score: 0.00
DE  Interaction: P05154; IntAct: EBI-735763; Score: 0.00
DE  Interaction: P11230; IntAct: EBI-736505; Score: 0.00
DE  Interaction: P23508; IntAct: EBI-1064987; Score: 0.00
DE  Interaction: Q99816; IntAct: EBI-2339285; Score: 0.37
DE  Interaction: Q15018; IntAct: EBI-8566862; Score: 0.35
DE  Interaction: Q92905; IntAct: EBI-2510150; Score: 0.91
DE  Interaction: Q9C0D3; IntAct: EBI-2510262; Score: 0.40
DE  Interaction: Q6TFL4; IntAct: EBI-2510262; Score: 0.56
DE  Interaction: Q96SW2; IntAct: EBI-2510262; Score: 0.67
DE  Interaction: Q9UNS2; IntAct: EBI-2510262; Score: 0.88
DE  Interaction: Q96Q07; IntAct: EBI-2510262; Score: 0.56
DE  Interaction: Q15048; IntAct: EBI-2510262; Score: 0.56
DE  Interaction: Q96EF6; IntAct: EBI-2510262; Score: 0.67
DE  Interaction: Q13618; IntAct: EBI-2510262; Score: 0.56
DE  Interaction: Q96M94; IntAct: EBI-2510262; Score: 0.56
DE  Interaction: Q8WXC6; IntAct: EBI-2510262; Score: 0.56
DE  Interaction: P15374; IntAct: EBI-2510262; Score: 0.40
DE  Interaction: Q13616; IntAct: EBI-2510262; Score: 0.62
DE  Interaction: Q9UBW8; IntAct: EBI-2510262; Score: 0.74
DE  Interaction: Q99627; IntAct: EBI-2510262; Score: 0.85
DE  Interaction: Q8NEZ5; IntAct: EBI-2510262; Score: 0.40
DE  Interaction: Q9P2J3; IntAct: EBI-2510262; Score: 0.56
DE  Interaction: Q13619; IntAct: EBI-2510262; Score: 0.74
DE  Interaction: Q9H078; IntAct: EBI-2510262; Score: 0.40
DE  Interaction: Q9H4M3; IntAct: EBI-2510262; Score: 0.56
DE  Interaction: Q9Y3I1; IntAct: EBI-2510262; Score: 0.67
DE  Interaction: Q13620; IntAct: EBI-2510262; Score: 0.56
DE  Interaction: Q13617; IntAct: EBI-2510262; Score: 0.67
DE  Interaction: Q15369; IntAct: EBI-2510262; Score: 0.56
DE  Interaction: Q53GT1; IntAct: EBI-2510262; Score: 0.56
DE  Interaction: Q9UK73; IntAct: EBI-2510262; Score: 0.67
DE  Interaction: B4DN30; IntAct: EBI-2510262; Score: 0.40
DE  Interaction: Q8TBC3; IntAct: EBI-2510262; Score: 0.40
DE  Interaction: Q9H496; IntAct: EBI-2510262; Score: 0.56
DE  Interaction: Q8TEB1; IntAct: EBI-2510262; Score: 0.67
DE  Interaction: Q13309; IntAct: EBI-2510262; Score: 0.67
DE  Interaction: Q9P2K6; IntAct: EBI-2510262; Score: 0.56
DE  Interaction: Q13216; IntAct: EBI-2510262; Score: 0.56
DE  Interaction: Q9NZJ0; IntAct: EBI-2510262; Score: 0.56
DE  Interaction: Q86XK2; IntAct: EBI-2510262; Score: 0.56
DE  Interaction: Q92466; IntAct: EBI-2510262; Score: 0.67
DE  Interaction: Q9BW61; IntAct: EBI-2510262; Score: 0.56
DE  Interaction: Q9BT78; IntAct: EBI-2510262; Score: 0.88
DE  Interaction: Q647K1; IntAct: EBI-2510262; Score: 0.40
DE  Interaction: Q9P2G9; IntAct: EBI-2510262; Score: 0.56
DE  Interaction: Q9Y597; IntAct: EBI-2510262; Score: 0.40
DE  Interaction: Q9H9Q2; IntAct: EBI-2510262; Score: 0.74
DE  Interaction: P61201; IntAct: EBI-2510262; Score: 0.81
DE  Interaction: Q9Y2M5; IntAct: EBI-2510262; Score: 0.40
DE  Interaction: Q96L50; IntAct: EBI-2510262; Score: 0.67
DE  Interaction: Q13098; IntAct: EBI-2510262; Score: 0.86
DE  Interaction: Q9Y4B6; IntAct: EBI-2510262; Score: 0.56
DE  Interaction: Q9H0C5; IntAct: EBI-2510262; Score: 0.67
DE  Interaction: P61024; IntAct: EBI-2510262; Score: 0.56
DE  Interaction: Q5XUX1; IntAct: EBI-2510262; Score: 0.56
DE  Interaction: Q15843; IntAct: EBI-2510262; Score: 0.56
DE  Interaction: Q9P2N7; IntAct: EBI-2510262; Score: 0.56
DE  Interaction: Q93034; IntAct: EBI-2510262; Score: 0.56
DE  Interaction: P24386; IntAct: EBI-2515120; Score: 0.40
DE  Interaction: Q3U1J4; IntAct: EBI-2559059; Score: 0.40
DE  Interaction: A0A6L8PK65; IntAct: EBI-2835415; Score: 0.00
DE  Interaction: Q13573; IntAct: EBI-7950968; Score: 0.35
DE  Interaction: Q9H3D4; IntAct: EBI-3936407; Score: 0.37
DE  Interaction: P04083; IntAct: EBI-7095166; Score: 0.37
DE  Interaction: P20073; IntAct: EBI-7097023; Score: 0.37
DE  Interaction: P38936; IntAct: EBI-7121191; Score: 0.37
DE  Interaction: Q16659; IntAct: EBI-7206027; Score: 0.37
DE  Interaction: Q16644; IntAct: EBI-7242276; Score: 0.37
DE  Interaction: P31947; IntAct: EBI-5279534; Score: 0.65
DE  Interaction: Q8NHY2; IntAct: EBI-5280877; Score: 0.52
DE  Interaction: Q9UBL3; IntAct: EBI-5654425; Score: 0.00
DE  Interaction: Q02556; IntAct: EBI-6115692; Score: 0.35
DE  Interaction: P12520; IntAct: EBI-6177205; Score: 0.35
DE  Interaction: Q96GG9; IntAct: EBI-21325177; Score: 0.35
DE  Interaction: Q5VW00; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: O15061; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: Q96ME1; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: Q12951; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: Q9H469; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: O94844; IntAct: EBI-21328549; Score: 0.53
DE  Interaction: Q8N1E6; IntAct: EBI-21328549; Score: 0.53
DE  Interaction: P10599; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: Q9H4B7; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: P68366; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: Q01085; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: O60506; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: P09234; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: P08621; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: P05141; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: P31040; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: P60866; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: P15880; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: P62244; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: P62263; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: P05386; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: P62917; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: Q02878; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: P36578; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: P62899; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: P83731; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: P62829; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: Q07020; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: Q06830; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: P13647; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: Q14568; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: O14979; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: Q99729; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: P13639; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: P53675; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: Q07021; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: P60709; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: P07437; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: Q9BQE3; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: Q92804; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: P62316; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: P62701; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: P05387; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: P62424; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: P62913; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: Q13610; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: P11940; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: P06748; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: P19838; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: P19338; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: O95678; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: P38646; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: P48741; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: P11021; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: P52597; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: Q14103; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: Q05639; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: P17844; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: O00571; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: P61962; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: P68371; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: Q9Y3Z3; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: P63173; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: P36639; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: P34931; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: Q9BUJ2; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: P31942; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: P31943; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: P22626; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: P62280; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: P61626; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: Q01546; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: Q2M2I5; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: P12268; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: P07900; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: P35637; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: P35527; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: P14625; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: Q01844; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: P06493; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: Q9UQE7; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: Q71RC2; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: Q92734; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: Q6P5R6; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: P11142; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: Q9BRP1; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: Q9H3F6; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: P35908; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: P04264; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: P61081; IntAct: EBI-21328549; Score: 0.53
DE  Interaction: P13645; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: Q8N1G4; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: Q96MP8; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: Q6PI47; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: Q9NXK8; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: Q53G59; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: P22830; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: O95219; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: Q96T23; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: P49642; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: O60237; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: Q8NDI1; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: Q9UGM3; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: Q6P3S6; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: Q96NC0; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: P13521; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: Q92834; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: Q9H4K1; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: Q05BQ5; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: Q8WXI2; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: P01042; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: Q9NXE8; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: Q6IMN6; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: Q9GZY4; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: Q9BYV9; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: O75110; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: Q9Y2J4; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: Q10570; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: Q15370; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: P63208; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: Q92673; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: Q00526; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: P78396; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: Q9NXF7; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: Q3SXM0; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: Q8WVD3; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: Q16531; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: O94889; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: O94952; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: Q5T6F0; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: Q92624; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: Q8WV16; IntAct: EBI-21328549; Score: 0.53
DE  Interaction: P24941; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: P20248; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: Q7Z7A1; IntAct: EBI-21328549; Score: 0.35
DE  Interaction: Q8N5D0; IntAct: EBI-21332205; Score: 0.35
DE  Interaction: Q5TAQ9; IntAct: EBI-21332205; Score: 0.35
DE  Interaction: Q5QP82; IntAct: EBI-21332205; Score: 0.35
DE  Interaction: Q96JK2; IntAct: EBI-21332205; Score: 0.35
DE  Interaction: Q8TEL6; IntAct: EBI-21332205; Score: 0.35
DE  Interaction: Q58WW2; IntAct: EBI-21332205; Score: 0.35
DE  Interaction: Q9C0C7; IntAct: EBI-21332205; Score: 0.35
DE  Interaction: Q53HC5; IntAct: EBI-21332205; Score: 0.35
DE  Interaction: P57775; IntAct: EBI-21332205; Score: 0.35
DE  Interaction: Q9Y297; IntAct: EBI-21332205; Score: 0.56
DE  Interaction: Q9UKB1; IntAct: EBI-21332205; Score: 0.35
DE  Interaction: Q9UK99; IntAct: EBI-21332205; Score: 0.35
DE  Interaction: Q8NBE8; IntAct: EBI-21332942; Score: 0.35
DE  Interaction: P05412; IntAct: EBI-11323169; Score: 0.35
DE  Interaction: P28482; IntAct: EBI-11477267; Score: 0.54
DE  Interaction: Q6UXH8; IntAct: EBI-25277037; Score: 0.56
DE  Interaction: Q8N6Y0; IntAct: EBI-25280965; Score: 0.56
DE  Interaction: Q13515; IntAct: EBI-24539227; Score: 0.56
DE  Interaction: Q15911; IntAct: EBI-24561815; Score: 0.56
DE  Interaction: Q92529; IntAct: EBI-24585832; Score: 0.56
DE  Interaction: O95704; IntAct: EBI-21591300; Score: 0.35
DE  Interaction: Q9BQ90; IntAct: EBI-21622599; Score: 0.35
DE  Interaction: A1L190; IntAct: EBI-21724977; Score: 0.35
DE  Interaction: Q6JEL2; IntAct: EBI-21755575; Score: 0.35
DE  Interaction: O43583; IntAct: EBI-21785701; Score: 0.35
DE  Interaction: Q9UKA1; IntAct: EBI-21796233; Score: 0.35
DE  Interaction: Q7L5Y6; IntAct: EBI-21846729; Score: 0.35
DE  Interaction: Q5S007; IntAct: EBI-21360986; Score: 0.35
DE  Interaction: P04156; IntAct: EBI-21014477; Score: 0.35
DE  Interaction: Q9NRI5; IntAct: EBI-21371036; Score: 0.00
DE  Interaction: P06241; IntAct: EBI-21371020; Score: 0.00
DE  Interaction: Q9BYB0; IntAct: EBI-26513938; Score: 0.37
DE  Interaction: Q15831; IntAct: EBI-28941407; Score: 0.53
GO  GO:0008180;
GO  GO:0005737;
GO  GO:0005829;
GO  GO:0005654;
GO  GO:0005634;
GO  GO:0048471;
GO  GO:0000338;
GO  GO:0045116;
GO  GO:2000434;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MAAAAAAAAATNGTGGSSGMEVDAAVVPSVMACGVTGSVSVALHPLVILNISDHWIRMRSQEGRPVQVIGALIGKQEGRN
SQ  IEVMNSFELLSHTVEEKIIIDKEYYYTKEEQFKQVFKELEFLGWYTTGGPPDPSDIHVHKQVCEIIESPLFLKLNPMTKH
SQ  TDLPVSVFESVIDIINGEATMLFAELTYTLATEEAERIGVDHVARMTATGSGENSTVAEHLIAQHSAIKMLHSRVKLILE
SQ  YVKASEAGEVPFNHEILREAYALCHCLPVLSTDKFKTDFYDQCNDVGLMAYLGTITKTCNTMNQFVNKFNVLYDRQGIGR
SQ  RMRGLFF
//