ID  Q7Z3G6;
PN  Prickle-like protein 2;
GN  PRICKLE2;
OS  9606;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0182;
SL  Comments: Nucleus membrane {ECO:0000305}.
DR  UNIPROT: Q7Z3G6;
DR  UNIPROT: Q0VF44;
DR  Pfam: PF00412;
DR  Pfam: PF06297;
DR  PROSITE: PS00478;
DR  PROSITE: PS50023;
DR  PROSITE: PS51303;
DR  OMIM: 608501;
DR  DisGeNET: 166336;
DE  Function: 
DE  Disease: Note=PRICKLE2 mutations have been found in patients with myoclonic epilepsy but involvement of this gene in pathogenesis is under debate since some of the patients also carry POLG mutations. {ECO:0000269|PubMed:21276947, ECO:0000269|PubMed:26942291, ECO:0000269|PubMed:26942292}.
DE  Reference Proteome: Yes;
DE  Interaction: A2A5Z6; IntAct: EBI-2349039; Score: 0.40
DE  Interaction: Q9UGN5; IntAct: EBI-7054206; Score: 0.44
GO  GO:0005737;
GO  GO:0031965;
GO  GO:0008270;
GO  GO:0060071;
TP  Membrane Topology: Lipid-Anchored; Source: UniProt - Experimental Evidence {ECO:0000269|PubMed:17411337};
SQ  MVTVMPLEMEKTISKLMFDFQRNSTSDDDSGCALEEYAWVPPGLKPEQVHQYYSCLPEEKVPYVNSPGEKLRIKQLLHQL
SQ  PPHDNEVRYCNSLDEEEKRELKLFSSQRKRENLGRGNVRPFPVTMTGAICEQCGGQINGGDIAVFASRAGHGVCWHPPCF
SQ  VCTVCNELLVDLIYFYQDGKIYCGRHHAECLKPRCAACDEIIFADECTEAEGRHWHMKHFCCFECETVLGGQRYIMKEGR
SQ  PYCCHCFESLYAEYCDTCAQHIGIDQGQMTYDGQHWHATETCFCCAHCKKSLLGRPFLPKQGQIFCSRACSAGEDPNGSD
SQ  SSDSAFQNARAKESRRSAKIGKNKGKTEEPMLNQHSQLQVSSNRLSADVDPLSLQMDMLSLSSQTPSLNRDPIWRSREEP
SQ  YHYGNKMEQNQTQSPLQLLSQCNIRTSYSPGGQGAGAQPEMWGKHFSNPKRSSSLAMTGHAGSFIKECREDYYPGRLRSQ
SQ  ESYSDMSSQSFSETRGSIQVPKYEEEEEEEGGLSTQQCRTRHPISSLKYTEDMTPTEQTPRGSMESLALSNATGLSADGG
SQ  AKRQEHLSRFSMPDLSKDSGMNVSEKLSNMGTLNSSMQFRSAESVRSLLSAQQYQEMEGNLHQLSNPIGYRDLQSHGRMH
SQ  QSFDFDGGMAGSKLPGQEGVRIQPMSERTRRRATSRDDNRRFRPHRSRRSRRSRSDNALHLASEREAISRLKDRPPLRAR
SQ  EDYDQFMRQRSFQESMGHGSRRDLYGQCPRTVSDLALQNAFGDRWGPYFAEYDWCSTCSSSSESDNEGYFLGEPIPQPAR
SQ  LRYVTSDELLHKYSSYGLPKSSTLGGRGQLHSRKRQKSKNCIIS
//