ID  Q806Y6;
PN  cap-snatching endonuclease;
GN  L;
OS  1980467;
SL  Nucleus Position: SL-0382;
SL  Comments: Host cytoplasm, host perinuclear region {ECO:0000250|UniProtKB:Q9YQR5}.
DR  UNIPROT: Q806Y6;
DR  Pfam: PF04196;
DR  Pfam: PF12426;
DR  PROSITE: PS50525;
DE  Function: RNA-dependent RNA polymerase, which is responsible for the replication and transcription of the viral RNA genome using antigenomic RNA as an intermediate (By similarity). During transcription, synthesizes subgenomic RNAs and assures their capping by a cap- snatching mechanism, which involves the endonuclease activity cleaving the host capped pre-mRNAs. These short capped RNAs are then used as primers for viral transcription. Cleaves ssRNA substrates but not DNA (By similarity). Seems to downregulate the expression of its own and heterologous mRNAs through its endonuclease activity (By similarity). {ECO:0000250|UniProtKB:Q9E005}.
DE  Reference Proteome: No;
GO  GO:0044220;
GO  GO:0004519;
GO  GO:0046872;
GO  GO:0000166;
GO  GO:0003968;
GO  GO:0075526;
GO  GO:0006351;
GO  GO:0039694;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MEKYREIHRDLQSFPVGSLTAVECIDYLDRLYAIRHDIVDQMIKHDWSDNKDSEESIGKVLLFAGVPNNVITAMEKKIIP
SQ  DHPSGKTLRSFFKMTPDNYKITGSTIEFVEVTVTVDVDKGIREKRLKYEAGLKYIEQELHNHFLRGDIPQPYKITFQVVS
SQ  VRTDGSNISTQWPSRRNDGVVQYMRLVQAEISYVREHLIRQEERAALEAMFNLKFNISNIKNQPYYIPDYRGIPLIHPNI
SQ  NDLVVYMRDWLSKSHKFSFHEGKVPAVFDCFNENELEHAVKYPISRHPRNFLLIQCSLLSSYNPATILSDQVDSRRACNS
SQ  VLNLIPETPTSFLIHDMAYRYINLTREDMVSFYAPKTQFIPTQNVKEPGTFKLTANSMRPESKAMLDMLGSHEPGEKKGA
SQ  LIESLNLSSHIVQSECVSLITKILSDLELNISEPTSHGSFTTKHTYVDNVLEKFFQNEIQRYLLDVLKKTTAWHIGHLIR
SQ  DITESLIAHSGLKRSKYWSVHAYNNGNVILFILPSKSLEVAGSYIRFVTVFRMGPGLVDKDNLDTILTDQDVTWGVSKVM
SQ  SIDLNRLLALNIAFEKALIATATWFQYYTEDQGQFPLQHAIRSVFAYHLLLAVCQKMKLCAIFDNLRYLIPAVTSLYSGF
SQ  PSLINKLFERPFKSALEVYVYYNIKSLLVALAQNNKARFYSKVKLLGLTVDQSTVGASGIYPSFMSRVIYKHYRSLISEV
SQ  TTCFFLFEKGLHGNMNEEAKIHLETVEWALKFRQKEDQYGESMVENGYTIGELNDNQDLVEQQLYCQDAVELAAVELNKI
SQ  LSTKSQVVANSILNKYWEVPYFSQTRNISLKGMSGQVQEDGHLAASVTIIEAIRYLSSSQNNPSVLQLYEETRKVKAQAR
SQ  IVRKYQRTEADRGFFITTLPTRCRLEIIEDYYDAISKNVAEEYISYGGERKILCIQSALEKALRWASGESFIELSNGKFI
SQ  RMKRKLMYVSADATKWSPGDNSAKFRRFTAALHNGLPDDRLKNCVIDALRNVYKTDFYMSRKLRAYIDNMNGHEPAVKNF
SQ  LEFFPDGHCGEVRGNWLQGNLNKCSSLFGVGMSLLFKQLWNELFPELDCFFEFAHHSDDALFIYGYLEPIDDGTDWFLYV
SQ  SQQIQAGHLHWFSVNTEMWKSMFNLHEHVLLLGSIKISPKKTTLSPTNAEFLSTFFESCAVSIPFIKILLGSLSDLPGLG
SQ  YFDDLAAAQSRCVKAMDLGASPQVAQLAVALCTNKVERLYGTAVGMIKHPSTYLQVKHGDTPIPLGGSGAMSIMELATAG
SQ  IGMSDKNLLKRALLGYIHKRQKNMAYILGLFKFLMNLSKDTFQHERLGEFSFIGKVQWKIFIPKSEFEFFDMYTPKFLKL
SQ  WSEQHVTYDYIIPKGRDNLLIYLVRKINDPSIVTAMTMQSPLQLRFRMQAKQHMKVCKLDDDWVTFREILAAANSFAQLY
SQ  EVTQEDLDLFQTLTSCTFSKEYAWKDFLNGVQCDVIPTKQIQRAKVARTFTVREKDQIIQNSIPAVIGYKFAVTVDEMSD
SQ  VLDSAKFPDSLAVDLKTMKDGVYRELGLDISQAEVMKKVAPMLYKSSKSRVVIVQGNVEGTAEAICGYWLRTMSLVKTIR
SQ  VKPHKEVLKAVSIFNRKEDIGQQKDLAALRLCIEVWRWCKANNAPYQEWFHALWFEDKTFSEWLDRFIRVGVPPVDPEIQ
SQ  CAALMIADIRGDLSVLQVQANRRAYSGKQYDAYCVQTYNEETKLYEGDLRVTFNFGLDCARLEIFWDKQTYILETSITQK
SQ  HVLKIMMDEVTKELLRCGMRFKTEQVSNVKHLVLFKTEAGFEWGKPNIPCIVYKNCALRTGLRANQTVNHKFMISIKDNG
SQ  LRAIAQYDDESPRFLLAHAFHTIRDIRYQAVDAVSNVWFIHKGIKLFLNPIISSGLLENFMKNLPAAIPPAAYSLIMNRA
SQ  KISVDLFMFNDLLRLINPSNTLDLSGLQPTEDGFSTVSSMSSRLWSEEVSFVDEDEEIDDEFTIDLQDVDFENIDVEADI
SQ  EHFLQDESSYTGDLLIMSEETEVKKMRGIIKLLEPVRLIKSWVSKGLCIEKVYSPTNIILMTRYLSKNFNFSGRQVSLLD
SQ  PYDLTEFESIVKGWGECVVDQFSTFDQETQLLVSQKGICPEDVVPDSLFSFRHTIVLLRRLFPQDSVSTFY
//