ID  Q80TH2;
PN  Erbin;
GN  Erbin;
OS  10090;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0182;
SL  Comments: Cell junction, hemidesmosome {ECO:0000250|UniProtKB:Q96RT1}. Nucleus membrane {ECO:0000269|PubMed:18802028}. Basolateral cell membrane {ECO:0000269|PubMed:16203728}. Note=Found in hemidesmosomes, which are cell-substrate adhesion complexes in stratified epithelia. In transfected cells, either diffusely distributed over the cytoplasm or concentrated at the basolateral membrane (By similarity). Colocalizes with the adrenergic receptors, ADREN1A and ADREN1B, at the nuclear membrane of cardiac myocytes. {ECO:0000250|UniProtKB:Q96RT1}.
DR  UNIPROT: Q80TH2;
DR  UNIPROT: E9QND6;
DR  UNIPROT: Q8BQ14;
DR  UNIPROT: Q8CE41;
DR  UNIPROT: Q8K171;
DR  UNIPROT: Q99JU3;
DR  UNIPROT: Q9JI47;
DR  Pfam: PF13855;
DR  Pfam: PF00595;
DR  PROSITE: PS51450;
DR  PROSITE: PS50106;
DE  Function: Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated ERBB2 'Tyr-1248' receptor, it may contribute to stabilize this unphosphorylated state (By similarity). Inhibits NOD2-dependent NF-kappa-B signaling and pro-inflammatory cytokine secretion (PubMed:16203728). {ECO:0000250|UniProtKB:Q96RT1, ECO:0000269|PubMed:16203728}.
DE  Reference Proteome: Yes;
DE  Interaction: P04626; IntAct: EBI-7806162; Score: 0.37
DE  Interaction: P70424; IntAct: EBI-7320494; Score: 0.67
DE  Interaction: Q8BUN5; IntAct: EBI-8626978; Score: 0.40
DE  Interaction: Q62432; IntAct: EBI-8627018; Score: 0.44
DE  Interaction: P70340; IntAct: EBI-8627088; Score: 0.44
DE  Interaction: P97471; IntAct: EBI-8627224; Score: 0.44
DE  Interaction: O35253; IntAct: EBI-8627324; Score: 0.44
DE  Interaction: P84022; IntAct: EBI-8627354; Score: 0.37
DE  Interaction: P52927; IntAct: EBI-9986179; Score: 0.35
DE  Interaction: Q9D415; IntAct: EBI-16725590; Score: 0.35
DE  Interaction: Q8VI24; IntAct: EBI-26885104; Score: 0.35
DE  Interaction: Q9QWI6; IntAct: EBI-27100778; Score: 0.35
GO  GO:0016323;
GO  GO:0030054;
GO  GO:0005737;
GO  GO:0098978;
GO  GO:0030056;
GO  GO:0031594;
GO  GO:0031965;
GO  GO:0016607;
GO  GO:0005634;
GO  GO:0005886;
GO  GO:0098794;
GO  GO:0099572;
GO  GO:0005176;
GO  GO:0005102;
GO  GO:0071356;
GO  GO:0071638;
GO  GO:0032088;
GO  GO:0070433;
GO  GO:0046579;
GO  GO:0006605;
GO  GO:0099072;
GO  GO:0032496;
GO  GO:0032495;
GO  GO:0007165;
TP  Membrane Topology: Unknown; Source: UniProt - Sequence Analysis;
SQ  MTTKRSLFVRLVPCRCLRGEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDND
SQ  LTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRL
SQ  TKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLREFWMDGNRLTFIPGFIGSLRQLTYLDVSKN
SQ  NIEMVEEGISTCENLQDFLLSSNSLQQLPETIGSLKNVTTLKIDENQLMYLPDSIGGLRSIEELDCSFNEIEALPSSIGQ
SQ  LTNMRTFAADHNYLQQLPPEIGNWKNITVLFLHCNKLETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSD
SQ  NQSKPLIPLQKETDTETQKMVLTNYMFPQQPRTEDVMFISDNESFNPALWEEQRKQRAQVAFECDEDKDEREAPPREGNL
SQ  KRYPTPYPDELKNMVKTVQTIVHRLKDEETNEESGRDLKQHEDQQVVNKDKCVKTSESTTTKSKLDEREKYMNSVQKMSE
SQ  PEAETNGGNLPVTASMKLSGNLKHIVNHDDVFEESEELSSDEEMKMAEMRPPLIESSINQPKVVALSNNKKDDAKDADSL
SQ  SDEVTHNSNQNNSNCSSPSRMSDSVSLNTDSSQDTSLCSPVKQTPVDSNSKVRQEDENFNSLLQNGVNLNNSPEEKFKIN
SQ  DKKDFKLPEYDLNIEEQLVLIEKDIDSKATSDDSRQLDHINMNINKLVTNNIFQPEVMERSKMQDIVLGTGFLSIHPKNE
SQ  AEHIENGAKFPNLESINKVNGLCEDTAPSPGRVEPQKASSSADVGISKSTEDLSPQRSGPTGAVVKSHSITNMETGGLKI
SQ  YDILGDDGPQPPSAAVKIASAVDGKNIVRSKSATLLYDQPLQVFTAASSSSELLSGTKAVFKFDSNHNPEEPDIIRAATV
SQ  SGPQSTPHLYGPPQYNVQYSGSATVKDTLWHPKQNPQIDPVSFPPQRLPRSESAENHSYAKHSANMNFSNHNNVRANTGY
SQ  HLQQRLAPARHGEMWAISPNDRLVPAVTRTTIQRQSSVSSTASVNLGDPTRRTEGDYLSYRELHSMGRTPVMSGSQRPLS
SQ  ARAYSIDGPNTSRPQSARPSINEIPERTMSVSDFNYSRTSPSKRPNTRVGSEHSLLDPPGKSKVPHDWREQVLRHIEAKK
SQ  LEKHPQTSSPGECCQDDRFMSEEQNHPSGALSHRGLPDSLMKMPLSNGQMGQPLRPQAHYSQTHHPPQASVARHPSREQL
SQ  IDYLMLKVAHQPPYTHPHCSPRQGHELAKQEIRVRVEKDPELGFSISGGVGGRGNPFRPDDDGIFVTRVQPEGPASKLLQ
SQ  PGDKIIQANGYSFINIEHGQAVSLLKTFHNAVDLIIVREVSS
//