ID  Q80UK8;
PN  Integrator complex subunit 2;
GN  Ints2;
OS  10090;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0182;
SL  Comments: Nucleus membrane {ECO:0000250|UniProtKB:Q9H0H0}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q9H0H0}.
DR  UNIPROT: Q80UK8;
DR  UNIPROT: Q5SXZ5;
DR  UNIPROT: Q5SXZ6;
DR  UNIPROT: Q6PCY7;
DR  UNIPROT: Q6ZPU6;
DR  UNIPROT: Q8CB15;
DR  UNIPROT: Q9CSE0;
DR  Pfam: PF14750;
DE  Function: Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex. {ECO:0000250|UniProtKB:Q9H0H0}.
DE  Reference Proteome: Yes;
DE  Interaction: D0ZIB5; IntAct: EBI-27035694; Score: 0.35
GO  GO:0005737;
GO  GO:0016021;
GO  GO:0032039;
GO  GO:0031965;
GO  GO:0005634;
GO  GO:0034472;
GO  GO:0016180;
TP  Membrane Topology: Transmembrane; Source: UniProt - Sequence Analysis {ECO:0000255};
SQ  MTPEGTGLQFVSPFAFEAMQKVDVVRLASLSDPELRLLLPCLVRMALCAPADQSQSWAQDKKLILRLLSGVEAVNSIVAL
SQ  LSVDFHALEQDASKEQQLRHKLGGGSGESILVSQLQHGLTLEFEHSDSPRRLRLVLSELLAIMNKVSECNGEFFFKSSEL
SQ  FESAVYLEEAADVLCILQAELPSLLPIVDVAEALLRVRNGAWFLCLLVANVPDSFNEVCRGLIKNGERQDEESLGGRRRT
SQ  DALRFLCRMNPSQALKVRGMVVEECHLPGLGVALTLDHTKTEACEDGVSDLVCFVSGLLLGTNAKVRTWFGTFIRNGQQR
SQ  KRETSGSVLWQMRRQLLLELMGILPTVRSTRIVEEADVEMEPTVSVYSGLKEEHVVKASALLRLYCALMGIAGLKPTEEE
SQ  AEQLLQLMTSRPPATPAGVRFVSLSFCMLLAFSTLVSTPEQEQLMVLWLSWMIKEEAYFESTSGVSASFGEMLLLVAMYF
SQ  HSNQLSAIIDLVCSTLGMKIVIKPSSLSRMKTIFTQEIFTEQVVTAHAVRVPVTSNLSANITGFLPIHCIYQLLRSRSFT
SQ  KHKVSIKDWIYRQLCETSTPLHPQLLPLIDVYINSILTPASKSNPEATNQPVTEQEILNLFQEVIGGDSVRLTQRFSITA
SQ  QLLVLYYILSYEEALLANTKTLASMQRKPKSYSSSLMDQIPIKFLIRQAQGLQQELGGLHSALLRLLATNYPHLCIVDDW
SQ  ICEEEITGTDALLRRMLLTSNAKTHSPKQLQEAFSAVPVSHTQVMQIMEHLTLLSASELIPYAEVLTSNMNQLLNSGVPR
SQ  RILQTVNKLWMVLNTVMPRRLWVMTVNALQPSIKFIRQQKYTQNDLMIDPLIVLRCDRRVHRCPPLMDVTLHMLNGYLLA
SQ  SKAYLSAHLKETAEQDRPSPNNTVGLVGQTDAPEVTREELKNALLAAQDSAAVQILLEICLPTEEEKAKGANSDISLRNT
SQ  QGVTTISTPSKETEEGEDNLLCNLREVQCLICCLLHQMYIADPNIAKLVHFQGYPCELLPLTVAGIPSMHICLDFIPELI
SQ  AQPELEKQIFAIQLLSHLCIQYALPKSLSVARLAVNVMGTLLTVLTQAKRYSFFMPTLPSLVSFCRAFPPLYEDIMSLLI
SQ  QIGQVCASDVATQTRDIDPIITRLQQIKEKPSGWSQICKDPSYKNGSRDTGSMDPDVQLCHCIESTIIEIINMSVSGI
//