ID  Q80W54;
PN  CAAX prenyl protease 1 homolog;
GN  Zmpste24;
OS  10090;
SL  Nucleus Position: SL-0178;
SL  Nucleus Position: SL-0179;
SL  Nucleus Position: SL-0182;
SL  Comments: Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Nucleus inner membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
DR  UNIPROT: Q80W54;
DR  UNIPROT: Q8BJK4;
DR  UNIPROT: Q8K569;
DR  Pfam: PF01435;
DR  Pfam: PF16491;
DE  Function: Transmembrane metalloprotease whose catalytic activity is critical for processing lamin A/LMNA on the inner nuclear membrane and clearing clogged translocons on the endoplasmic reticulum (PubMed:11923874). Proteolytically removes the C-terminal three residues of farnesylated proteins. Plays also an antiviral role independently of its protease activity by restricting enveloped RNA and DNA viruses, including influenza A, Zika, Ebola, Sindbis, vesicular stomatitis, cowpox, and vaccinia (PubMed:28246125). Mechanistically, controls IFITM antiviral pathway to hinder viruses from breaching the endosomal barrier by modulating membrane fluidity (PubMed:28246125). {ECO:0000250|UniProtKB:O75844, ECO:0000269|PubMed:11923874, ECO:0000269|PubMed:28246125}.
DE  Reference Proteome: Yes;
GO  GO:0030176;
GO  GO:0016020;
GO  GO:0005635;
GO  GO:0005637;
GO  GO:0032991;
GO  GO:0003690;
GO  GO:0004175;
GO  GO:0046872;
GO  GO:0004222;
GO  GO:0007628;
GO  GO:0030282;
GO  GO:0071586;
GO  GO:1990036;
GO  GO:0061762;
GO  GO:0061337;
GO  GO:0055013;
GO  GO:0003231;
GO  GO:0044255;
GO  GO:0006974;
GO  GO:0071480;
GO  GO:0006325;
GO  GO:0051276;
GO  GO:0008340;
GO  GO:0006281;
GO  GO:0008544;
GO  GO:0003417;
GO  GO:0001942;
GO  GO:0003007;
GO  GO:0043969;
GO  GO:0043979;
GO  GO:0044029;
GO  GO:0006925;
GO  GO:0060993;
GO  GO:0001889;
GO  GO:0043007;
GO  GO:0035264;
GO  GO:0010629;
GO  GO:1903799;
GO  GO:0050905;
GO  GO:0006998;
GO  GO:0006997;
GO  GO:0010628;
GO  GO:0030327;
GO  GO:0016485;
GO  GO:0010506;
GO  GO:1903522;
GO  GO:0030500;
GO  GO:0008360;
GO  GO:2000772;
GO  GO:0050688;
GO  GO:0043516;
GO  GO:0044030;
GO  GO:0006355;
GO  GO:0048145;
GO  GO:0010906;
GO  GO:0008016;
GO  GO:0090239;
GO  GO:2000618;
GO  GO:0032350;
GO  GO:0019216;
GO  GO:0007346;
GO  GO:1903463;
GO  GO:0040014;
GO  GO:1903025;
GO  GO:0070302;
GO  GO:2000730;
GO  GO:0032006;
GO  GO:0060307;
GO  GO:0072423;
GO  GO:0048538;
GO  GO:0003229;
TP  Membrane Topology: Transmembrane; Source: UniProt - Sequence Analysis {ECO:0000255};
SQ  MGMWASVDAMWDFPAEKRIFGAVLLFSWTVYLWETFLAQRQRRIYKTTTRVPAELEQIMDSDTFEKSRLYQLDKSTFSFW
SQ  SGLYSEVEGTFILLFGGIPYLWRLSGQFCSSAGFGPEYEIIQSLVFLLLATLFSALTGLPWSLYNTFVIEEKHGFNHQTL
SQ  EFFMKDAIKKFIVTQCILLPVSALLLYIIKIGGDYFFIYAWLFTLVVSLVLVTIYADYIAPLFDKFTPLPEGKLKQEIEV
SQ  MAKSIDFPLTKVYVVEGSKRSSHSNAYFYGFFKNKRIVLFDTLLEEYSVPNKDNQEESGMEARNEGEGDSEEVKAKVKNK
SQ  KQGCKNEEVLAVLGHELGHWKLGHTVKNIIISQMNSFLCFFLFAVLIGRRELFAAFGFYDSQPTLIGLLIIFQFIFSPYN
SQ  EVLSFCLTVLSRRFEFQADAFAKKLGKAKDLYSALIKLNKDNLGFPVSDWLFSTWHYSHPPLLERLQALKNAKQD
//