ID  Q80W94;
PN  2-acylglycerol O-acyltransferase 2;
GN  Mogat2;
OS  10090;
SL  Nucleus Position: SL-0198;
SL  Comments: Endoplasmic reticulum membrane {ECO:0000269|PubMed:14966132}; Multi-pass membrane protein {ECO:0000269|PubMed:14966132}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q3SYC2}.
DR  UNIPROT: Q80W94;
DR  Pfam: PF03982;
DE  Function: Catalyzes the formation of diacylglycerol from 2- monoacylglycerol and fatty acyl-CoA. Has a preference toward monoacylglycerols containing unsaturated fatty acids in an order of C18:3 > C18:2 > C18:1 > C18:0. Plays a central role in absorption of dietary fat in the small intestine by catalyzing the resynthesis of triacylglycerol in enterocytes. May play a role in diet-induced obesity. Also able to use 1-monoalkylglycerol (1-MAkG) as an acyl acceptor for the synthesis of monoalkyl-monoacylglycerol (MAMAG) (By similarity). {ECO:0000250|UniProtKB:Q3SYC2, ECO:0000269|PubMed:12576479, ECO:0000269|PubMed:12730219, ECO:0000269|PubMed:14966132}.
DE  Reference Proteome: Yes;
GO  GO:0005783;
GO  GO:0005789;
GO  GO:0016021;
GO  GO:1990578;
GO  GO:0003846;
GO  GO:0016407;
GO  GO:0006651;
GO  GO:0006071;
GO  GO:0050892;
GO  GO:0006629;
GO  GO:0006640;
GO  GO:0046462;
GO  GO:0019432;
TP  Membrane Topology: Transmembrane; Source: UniProt - Sequence Analysis {ECO:0000255};
SQ  MVEFAPLLVPWERRLQTFAVLQWVFSFLALAQLCIVIFVGLLFTRFWLFSVLYATWWYLDWDKPRQGGRPIQFFRRLAIW
SQ  KYMKDYFPVSLVKTAELDPSRNYIAGFHPHGVLAAGAFLNLCTESTGFTSLFPGIRSYLMMLTVWFRAPFFRDYIMSGGL
SQ  VSSEKVSADHILSRKGGGNLLAIIVGGAQEALDARPGAYRLLLKNRKGFIRLALMHGAALVPIFSFGENNLFNQVENTPG
SQ  TWLRWIQNRLQKIMGISLPLFHGRGVFQYSFGLMPFRQPITTIVGKPIEVQMTPQPSREEVDRLHQRYIKELCKLFEEHK
SQ  LKFNVPEDQHLEFC
//